Preparation of Rat Model of Diabetic Cystopathy (DCP) and the Changes of Urodynamics of Rats with DCP

Ma Jian Fei; Wang Song; Su Ting; Tang Yan; Zhang Yu Quan; Fang Ke Wei

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Ma Jian Fei , Wang Song , Su Ting , Tang Yan , Zhang Yu Quan , Fang Ke Wei . Preparation of Rat Model of Diabetic Cystopathy (DCP) and the Changes of Urodynamics of Rats with DCP[J]. Journal of Kunming Medical University, 2017, 38(09): 87-91.

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Ma Jian Fei , Wang Song , Su Ting , Tang Yan , Zhang Yu Quan , Fang Ke Wei . Preparation of Rat Model of Diabetic Cystopathy (DCP) and the Changes of Urodynamics of Rats with DCP[J]. Journal of Kunming Medical University, 2017, 38(09): 87-91.

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Preparation of Rat Model of Diabetic Cystopathy (DCP) and the Changes of Urodynamics of Rats with DCP

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2015FB086); 云南省教育厅科学研究基金资助项目 (2015C005Z); 昆明医科大学校级大学生创新性研究基金资助项目 (CX201581);

Received Date: 2017-06-05

Abstract

Abstract

Objective To explore the modeling of diabetic cystopathy (DCP) and the changes of urodynamics in rats with DCP.Methods 40 female rats (200-250 g) were divided into two groups: group A, the controlled group (22 rats) and group B (18 rats) , the experimental group.The model of DCP (experimental group) was established with the intraperitoneal injection of streptozotocin (STZ) after 4 weeks feeding of high-sugar high-fat.Group A was injected citrate buffer intraperitoneally (the same dose of STZ) after 4 weeks normal feeding.Both groups were tested the blood sugar through the tail vein, 1 time a week, four times altogether.Twelve weeks later, the bladder capacity, bladder pressure and leakage point pressure were tested with urodynamic instument.The results were tested 3 times.Results The blood sugar of group B was higher obviously than group A.And the successful modeling rate of DCP with STZ was 100%.Compared wth group A, the filling bladder capacity was higher significantly, the bladder pressure and leakage point pressure were lower significantly in group B.Conclusion The successful modeling rate of DCP with STZ is high and the urethra and bladder function changes are significant in DCP rats.
- Diabetic cystopathy,
- Streptozotocin,
- Diabetes millitus 2,
- Urodynamics

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References(20)

References

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