Comparative Study of Paliperidone ER Tablets and Risperidone Tablets in Treatment of Childhood and Adolescents First Episode Schizophrenia

Lei Jie Peng; Yang Li; Luo Cheng; Zhang Ti Yuan; Lv Xin; Li Sheng Qiao; Lin Hai Bo

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Article Navigation > Journal of Kunming Medical University > 2017 > 38(09): 92-95

Lei Jie Peng , Yang Li , Luo Cheng , Zhang Ti Yuan , Lv Xin , Li Sheng Qiao , Lin Hai Bo . Comparative Study of Paliperidone ER Tablets and Risperidone Tablets in Treatment of Childhood and Adolescents First Episode Schizophrenia[J]. Journal of Kunming Medical University, 2017, 38(09): 92-95.

Citation:

Lei Jie Peng , Yang Li , Luo Cheng , Zhang Ti Yuan , Lv Xin , Li Sheng Qiao , Lin Hai Bo . Comparative Study of Paliperidone ER Tablets and Risperidone Tablets in Treatment of Childhood and Adolescents First Episode Schizophrenia[J]. Journal of Kunming Medical University, 2017, 38(09): 92-95.

Citation:

Lei Jie Peng , Yang Li , Luo Cheng , Zhang Ti Yuan , Lv Xin , Li Sheng Qiao , Lin Hai Bo . Comparative Study of Paliperidone ER Tablets and Risperidone Tablets in Treatment of Childhood and Adolescents First Episode Schizophrenia[J]. Journal of Kunming Medical University, 2017, 38(09): 92-95.

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Comparative Study of Paliperidone ER Tablets and Risperidone Tablets in Treatment of Childhood and Adolescents First Episode Schizophrenia

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (20150121);

Received Date: 2017-04-17

Abstract

Abstract

Objective To explore the efficacy and safety of Paliperidone extended-release tablets (Paliperidone ER) and Risperidone tablets in treatment of childhood and adolescents first episode schizophrenia.Methods 66 children with first-episode schizophrenia were randomly divided into Paliperidone group (n=33, treated with Paliperidone ER) and Risperidone group (n=33, orally took Risperidone tablets) and treated for 8 weeks.The efficacy and adverse reactions were assessed with positive and negative syndrome scale (PANSS) and treatment emergent symptom scale (TESS) before and 1, 2, 4, 8 weeks after the treatment.Results The total score and the factor scores of PANSS in the two groups were significantly decreased after the treatment (P<0.05 or P<0.01) .At the first weekend, the score of PANSS was significantly lower in Paliperidone group than that in the Risperidone group (P<0.05) .The other factors had no significant differences (P>0.05) .In comparison of the adverse reactions between the two groups, the adverse drug reaction incidence of Paliperidone group was lower than that of Risperidone group (P <0.01) .Conclusions Paliperidone ER in the treatment of childhood and adolescents first episode schizophrenia has a rapid effect, less adverse reactions, and a high safety.
- Aliperidone ER,
- Risperidone tablets,
- Schizophrenia

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References(17)

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