Prevention of Postherpetic Neuralgia by Nerve Block and Analysis of Risk Factors

Zhang Xi Li; Meng Wen; Li Qing Ye; Wang Guo Liang; Li Yan Lin; Zhang Xiao Mei

Volume 38 Issue 09

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Zhang Xi Li , Meng Wen , Li Qing Ye , Wang Guo Liang , Li Yan Lin , Zhang Xiao Mei . Prevention of Postherpetic Neuralgia by Nerve Block and Analysis of Risk Factors[J]. Journal of Kunming Medical University, 2017, 38(09): 96-99.

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Prevention of Postherpetic Neuralgia by Nerve Block and Analysis of Risk Factors

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基金：云南省骨关节疾病诊疗省创新团队基金资助项目 (2014HC1018);

Received Date: 2017-04-21

Abstract

Abstract

Objective To investigate the effect of nerve block on the treatment of herpes zoster (HZ) and prevention of postherpetic neuralgia (PHN) , and to explore the factors that affect the occurrence of PHN.Methods From january 2015 to September 2016 in our hospital 80 acute HZ patients for the first time in the treatment of pain, were randomly assigned to the case group (nerve block + conventional medical treatment) 40 cases, and the control group (conventional medical treatment) 40 cases.The incidence of neuralgia in the two groups was analyzed, and the relationship between the age, sex, herpes, prodromal pain, initial pain, scab time, pain relief rate and PHN.Results PHN occurred in 4 cases (10.0%) in the case group and 19 cases (47.5%) in the control group (P <0.001) . (6.33 ± 0.86 days vs.7.15 ± 0.66 days, P <0.001) .The number of hospital days decreased (7.43 ± 1.80 days vs.12.90 ± 2.36 days, P <0.001) .Ageing (OR: 8.24, 95% CI:1.62-41.96) and prolonged crusting time (OR: 17.99, 95% CI: 2.14-151.43) , are risk factors for PHN, significantly increased the incidence of PHN.The VAS remission rate after 1 week (OR <0.000, 95% CI:0.000-0.001) was a protective factor for PHN and was negatively correlated with PHN.Conclusions Aging and onset of severe pain in patients should pay attention to the prevention of PHN.Nerve block helps to reduce the number of hospital stay in HZ patients, shorten the scab time, and reduce the incidence of PHN.
- Herpes zoster,
- Postherpetic neuralgia,
- High risk factors,
- Nerve block

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