Diagnostic Value of Combined Detection of Multiple Tumor Markers in Colorectal Cancer

Luo Shao Lei; Ma Li Ju; Ma Teng Fei; Shao Wen Ping

Article Contents

Article Navigation > Journal of Kunming Medical University > 2017 > 38(10): 101-106

Luo Shao Lei , Ma Li Ju , Ma Teng Fei , Shao Wen Ping . Diagnostic Value of Combined Detection of Multiple Tumor Markers in Colorectal Cancer[J]. Journal of Kunming Medical University, 2017, 38(10): 101-106.

Citation:

Luo Shao Lei , Ma Li Ju , Ma Teng Fei , Shao Wen Ping . Diagnostic Value of Combined Detection of Multiple Tumor Markers in Colorectal Cancer[J]. Journal of Kunming Medical University, 2017, 38(10): 101-106.

Citation:

PDF( 276 KB)

Diagnostic Value of Combined Detection of Multiple Tumor Markers in Colorectal Cancer

Funds:

基金：国家自然科学基金资助项目 (81160276); 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2011FB181);

Received Date: 2017-04-10

Abstract

Abstract

Objective To investigate the serum expression of tumor markers in patients with colorectal cancer, and evaluate the value of combined detection of multiple tumor markers in clinical diagnosis. Methods The serum levels of 12 tumor markers (CA125, CA153, CA199, CA242, CEA, AFP, NSE, Free-PSA, PSA, β-HCG, HGH, Ferritin) in 134 patients with colorectal cancer and 293 healthy controls were analyzed by C-12 protein chip. The results were analyzed by statistical methods. Results The serum levels of tumor markers, including CEA, CA199, CA242, AFP, CA125, β-HCG in patients with colorectal cancer were significantly higher than the healthy controls (P<0.05) . The positive rate of C-12 protein chip was 74.63% in patients with colorectal cancer, significantly higher than the positive rates in healthy controls (10.24%) .CEA+CA199+CA242+CA125+AFP combined detection had the highest efficiency. Diagnostic sensitivity and specificity was greatly improved by combined detection. Conclusions Combined detection of multiple tumor markers has significant value for the diagnosis in the patients with colorectal cancer.CEA+CA199+CA242+CA125+AFP combined detection can be used as markers for colorectal cancer diagnosis, which may improve diagnostic efficiency.
- Colorectal cancer,
- Tumor markers,
- Protein chip,
- Diagnosis

FullText(HTML)

References(13)

References

[1]	[1]International agency for research on cancer.globocan2012:estimated cancer incidence, mortality and prevalence worldwide in2012[EB/OL].[2016-03-13].http://globocan.iarc.fr/Pages/fact_sheets_population.aspx.
[2]	[2]MCKEOWN E, NELSON D W, JOHNSON E K, et al.Current approaches and challenges for monitoring treatment response in colon and rectal cancer[J].J Cancer, 2014, 5 (1) :31-43.
[3]陈卫中, 倪宗瓒, 潘晓平, 等.用ROC曲线确定最佳临界点和可疑值范围[J].现代预防医学, 2005, 32 (7) :729-731.
[4]张亚南, 冀杨, 贾楠, 等.多肿瘤标志物蛋白芯片检测系统在消化系统疾病的应用评价[J].中国实验诊断学, 2011, 15 (3) :500-503.
[5]孔宪涛.肿瘤标志物应用进展与评价[J].实用肿瘤杂志, 2002, 17 (5) :289-292.
[6]	[6]THOMAS D S, FOURKALA E O, APOSTOLIDOU S, et al.Evaluation of serum CEA, CYFRA21-1 and CA125 for the early detection of colorectal cancer using longitudinal preclinical samples[J].Br J Cancer, 2015, 113 (2) :268-274.
[7]	[7]ZHONG W, YU Z, ZHAN J, et al.Association of serum levels of CEA, CA199, CA125, CYFRA21-1 and CA72-4and disease characteristics in colorectal cancer[J].Pathol Oncol Res, 2015, 21 (1) :83-95.
[8]	[8]STURGEON C.Practice guidelines for tumor marker use in the clinic[J].Clin Chem, 2002, 48 (8) :1151-1159.
[9]陈魁.大肠癌肿瘤标志物研究进展[J].现代中西医结合杂志, 2008, 17 (36) :5706-5709.
[10]	[10]YANG X Q, CHEN C, PENG C W, et al.Carbohydrate antigen 242 highly consists with carbohydrate antigen 19-9 in diagnosis and prognosis of colorectal cancer:study on 185cases[J].Med Oncol, 2012, 29 (2) :1030-1036.
[11]	[11]SELCUKBIRICIK F, BILICI A, TURALD, et al.Are high initial CEA and CA 19-9 levels associated with the presence of K-ras mutation in patients with metastatic colorectal cancer[J].Tumour Biol, 2013, 34 (4) :2233-2239.
[12]	[12]YOO T, LEE K W, YI N J, et al.Peri-transplant change in AFP level:a useful predictor of hepatocellular carcinoma recurrence following liver transplantation[J].J Korean Med Sci, 2016, 31 (7) :1049-1054.
[13]茅翔, 罗奋, 陈宗祐, 等.提高对胃肝样腺癌和产甲胎蛋白胃癌的认识[J].中华肿瘤杂志, 2015, 37 (6) :401-403.

Relative Articles(20)

Relative Articles

[1]	Ruicheng LI, Hongwei QIAN, Yanni FAN, Peipei ZHAO, Shan WEI, Huarong JING. Application of Logistic Regression and Artificial Neural Networks in the Differential Diagnosis of LC-MPE. Journal of Kunming Medical University, 2024, 45(10): 55-60. doi: 10.12259/j.issn.2095-610X.S20241009
[2]	Yiling ZUO, Jiayan SUN, Limei MING, Guilan ZHANG, Yunxia SHEN, Xiaolin ZHANG. The Health Education Based on Cognitive Behavioral Therapy in Patients with Colorectal Cancer during the Chemotherapy Intervals and Its Application in the Virtual Community Nursing. Journal of Kunming Medical University, 2024, 45(11): 174-180. doi: 10.12259/j.issn.2095-610X.S20241125
[3]	Yan WANG, Rong DING, Lvling ZHANG, Ruohua WANG, Xiaoling ZHAO, Na MA. Efficacy of Blood Transfusion Combined with Chemoradiotherapy in Patients with Colorectal Cancer and its Effect on Tumor Markers and T Lymphocyte Levels. Journal of Kunming Medical University, 2022, 43(8): 61-65. doi: 10.12259/j.issn.2095-610X.S20220809
[4]	Luo Xiao Mao . Application of Double Contrast-enhanced Ultrasonography in the Diagnosis of Gastric Cancer. Journal of Kunming Medical University,
[5]	Li Dong Bo . . Journal of Kunming Medical University,
[6]	Zhang Tao . . Journal of Kunming Medical University,
[7]	Liu Fang . . Journal of Kunming Medical University,
[8]	Yang Shao Hua . . Journal of Kunming Medical University,
[9]	Dang Yong . . Journal of Kunming Medical University,
[10]	Zhang Ming Qian . . Journal of Kunming Medical University,
[11]	Xu Jian Xin . . Journal of Kunming Medical University,
[12]	Fang Ke Wei . . Journal of Kunming Medical University,
[13]	Lu Jian Fei . . Journal of Kunming Medical University,
[14]	Li Ding Biao . . Journal of Kunming Medical University,
[15]	Hao Ying Hao . . Journal of Kunming Medical University,
[16]	Rui Qiao An . . Journal of Kunming Medical University,
[17]	Yang Yi Ming . Clinical Experiences in Diagnosis and Treatment of Intestinal Obstruction of 48 Patients with Colorectal Cancer. Journal of Kunming Medical University,
[18]	. . Journal of Kunming Medical University,
[19]	. . Journal of Kunming Medical University,
[20]	Dong Xin Xin . . Journal of Kunming Medical University,