Diagnostic Value of Combined Detection of Multiple Tumor Markers in Colorectal Cancer

Luo Shao Lei; Ma Li Ju; Ma Teng Fei; Shao Wen Ping

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Luo Shao Lei , Ma Li Ju , Ma Teng Fei , Shao Wen Ping . Diagnostic Value of Combined Detection of Multiple Tumor Markers in Colorectal Cancer[J]. Journal of Kunming Medical University, 2017, 38(10): 101-106.

Citation:

Luo Shao Lei , Ma Li Ju , Ma Teng Fei , Shao Wen Ping . Diagnostic Value of Combined Detection of Multiple Tumor Markers in Colorectal Cancer[J]. Journal of Kunming Medical University, 2017, 38(10): 101-106.

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Diagnostic Value of Combined Detection of Multiple Tumor Markers in Colorectal Cancer

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基金：国家自然科学基金资助项目 (81160276); 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2011FB181);

Received Date: 2017-04-10

Abstract

Abstract

Objective To investigate the serum expression of tumor markers in patients with colorectal cancer, and evaluate the value of combined detection of multiple tumor markers in clinical diagnosis. Methods The serum levels of 12 tumor markers (CA125, CA153, CA199, CA242, CEA, AFP, NSE, Free-PSA, PSA, β-HCG, HGH, Ferritin) in 134 patients with colorectal cancer and 293 healthy controls were analyzed by C-12 protein chip. The results were analyzed by statistical methods. Results The serum levels of tumor markers, including CEA, CA199, CA242, AFP, CA125, β-HCG in patients with colorectal cancer were significantly higher than the healthy controls (P<0.05) . The positive rate of C-12 protein chip was 74.63% in patients with colorectal cancer, significantly higher than the positive rates in healthy controls (10.24%) .CEA+CA199+CA242+CA125+AFP combined detection had the highest efficiency. Diagnostic sensitivity and specificity was greatly improved by combined detection. Conclusions Combined detection of multiple tumor markers has significant value for the diagnosis in the patients with colorectal cancer.CEA+CA199+CA242+CA125+AFP combined detection can be used as markers for colorectal cancer diagnosis, which may improve diagnostic efficiency.
- Colorectal cancer,
- Tumor markers,
- Protein chip,
- Diagnosis

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References(13)

References

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