Surveillance of Antimicrobial Resistance of Haemophilus influenzae in First Affiliated Hospital of Kunming Medical University during 2012 and 2015

Ren Xiao Yan; Mao Jian

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Ren Xiao Yan , Mao Jian . Surveillance of Antimicrobial Resistance of Haemophilus influenzae in First Affiliated Hospital of Kunming Medical University during 2012 and 2015[J]. Journal of Kunming Medical University, 2017, 38(10): 45-49.

Citation:

Ren Xiao Yan , Mao Jian . Surveillance of Antimicrobial Resistance of Haemophilus influenzae in First Affiliated Hospital of Kunming Medical University during 2012 and 2015[J]. Journal of Kunming Medical University, 2017, 38(10): 45-49.

Citation:

Ren Xiao Yan , Mao Jian . Surveillance of Antimicrobial Resistance of Haemophilus influenzae in First Affiliated Hospital of Kunming Medical University during 2012 and 2015[J]. Journal of Kunming Medical University, 2017, 38(10): 45-49.

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Surveillance of Antimicrobial Resistance of Haemophilus influenzae in First Affiliated Hospital of Kunming Medical University during 2012 and 2015

Ren Xiao Yan ¹,
Mao Jian ²

Funds:

基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2014FB034);

Received Date: 2017-05-12

Abstract

Abstract

Objective To investigate the antibiotic resistance of clinical strains of Haemophilus in fluenzae (HI) isolated from the First Affiliated Hospital of Kunming Medical University, to provide scientific data for using antibiotic in clinic rationally. Methods Clinical strains of HI were collected from January2012 to December 2015, Kirby-Bauer method was used to antimicrobial susceptibility test, beta-lactamases were detected by nitrocefin disk test. Data from antibiotic resistance of HI were analyzed by WHONET5.6. Results Among the 184 clinical strains of HI, the resistance rate to ampicillin, chloramphenicol, ampicillin\sulbactam was 46.7%, 23.2%, 13%, respectively. About 90% of these HI strains were still susceptible to azithromvcin, ciprofloxacin, meropenem, cefuroxime, cefotaxime. The resistance rate to ampicillin in the HI strains from children (56.9%) were higher than in the strains from adults (42.1%) , the resistance rate to ciprofloxacin, chloramphenicol, meropenem was in HI strains from children, significantly higher than in the strains from adults. The overall prevalence of beta-lactamases was 52.8% in the HI strains. The prevalence of beta-lactamases (64.3%) in the strains from children was higher than the prevalence of beta-lactamases (47.6%) in the strains from adults. There are one HIstrain resistant to ampicillin but beta-lactamases negative. Conclusions HI was mainly isolated from respiratory specimen and hospitalized patients. Ampicillin is inapplicable to empiric treatment for HI. Cephalosporin antibiotic, macrolides, enzyme inhibitor, quinlone, carbapenemases are stably susceptible. Beta-lactamase is the important mechanism of resistance.
- Haemophilus influenzae,
- Kirby-Bauer method,
- Beta-lactamases,
- Drug resistance

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References(16)

References

[1]牛翠, 张辉, 杨启文, 等.2008-2011年北京协和医院流感嗜血杆菌耐药性监测[J], 中国感染与化疗杂志, 2013, 13 (6) :476-480.
[2]	[2]Clinical and Laboratory standards Institute.performance Standards for antimicrobial susceptibility testing[s].Twenty-fourth informational Supplement, 2014, M100-S24.
[3]张泓, 孔菁, 王传清, 等, 2010中国CHINET流感嗜血杆菌和卡他莫拉菌耐药性监测[J].中国感染与化疗杂志, 2012, 12 (3) :180-184.
[4]孙燕, 孔菁, 张泓, 等.2005-2014中国CHINET流感嗜血杆菌和卡他莫拉菌耐药性监测[J].中国感染与化疗杂志, 2016, 16 (2) :153-159.
[5] 宁静, 韦桂雪肺炎链球菌和流感嗜血杆菌分布及耐药性分析[J].医学检验与临床, 2013, 24 (5) :37-39.
[6]杨晓华, 谭南, 林爱心, 等.儿童呼吸道流感嗜血杆菌的耐药分析[J].中国感染与化疗杂志, 2014, 14 (5) :436-439.
[7]楚文英, 临床微生物实验室需重视嗜血杆菌的分离培养[J].国际检验医学杂志, 2011, 32 (18) :2160-2162.
[8]田磊, 张真, 陈中举, 等.某院流感嗜血杆菌耐药性及其对氨苄西林耐药机制[J].中国感染控制杂志, 2015, 14 (2) :73-76.
[9]胡付品, 朱德妹, 汪复, 等, 2014年CHINET中国细菌耐药性检测[J].中国感染与化疗杂志, 2015, 15 (5) :401-410.
[10]张泓, 李万华, 王传清等, 2007中国CHINET流感嗜血杆菌耐药性检测[J].中国感染与化疗杂志, 2009, 9 (3) :207-209.
[11]刘东华, 胡艳华, 王少敏.5岁以下儿童呼吸道感染流感嗜血杆菌血清学分型及耐药性分析[J].儿科药学杂志, 2014, 20 (12) :27-29.
[12]王海磊, 马娜, 娄春艳.儿科患者感染流感嗜血杆菌耐药基因检测及耐药性分析[J].中国病原微生物杂志, 2015, 10 (11) :1031-1034.
[13]潘芬, 刘昌颀, 王春等.儿童感染流感嗜血杆菌的流行病学及耐药机制研[J].中华医学感染学杂志, 2016, 26 (24) :5700-5703.
[14]谢成彬, 王频佳, 吴雨露, 等.儿童呼吸道流感嗜血杆菌分离株耐药性与fts I基因分型研究[J].中国感染与化疗杂志, 2015, 15 (4) :324-329.
[15]钱利强, 程薇, 华春珍.流感嗜血杆菌对氨苄西林耐药性及耐药机制研究进展[J].中国抗生素杂志, 2009, 34 (2) :69-72.
[16]董方, 王艳, 刘锡青, 等.2009-2015年北京儿童医院临床分离细菌的分布及耐药性监测[J].中国感染与化疗杂志, 2017, 17 (1) :61-70.

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