Clinical Value of Myocardial Injury Markers in Evaluating Cardiac Structure and Function of Chronic Kidney Disease Patients without Dialysis

Jiang Hong Ying; Dou Li Na; Liao Yun Juan; Zeng Yi; Bai Yi Hua; Yang Min

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Jiang Hong Ying , Dou Li Na , Liao Yun Juan , Zeng Yi , Bai Yi Hua , Yang Min . Clinical Value of Myocardial Injury Markers in Evaluating Cardiac Structure and Function of Chronic Kidney Disease Patients without Dialysis[J]. Journal of Kunming Medical University, 2017, 38(10): 50-54.

Citation:

Jiang Hong Ying , Dou Li Na , Liao Yun Juan , Zeng Yi , Bai Yi Hua , Yang Min . Clinical Value of Myocardial Injury Markers in Evaluating Cardiac Structure and Function of Chronic Kidney Disease Patients without Dialysis[J]. Journal of Kunming Medical University, 2017, 38(10): 50-54.

Citation:

Jiang Hong Ying , Dou Li Na , Liao Yun Juan , Zeng Yi , Bai Yi Hua , Yang Min . Clinical Value of Myocardial Injury Markers in Evaluating Cardiac Structure and Function of Chronic Kidney Disease Patients without Dialysis[J]. Journal of Kunming Medical University, 2017, 38(10): 50-54.

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Clinical Value of Myocardial Injury Markers in Evaluating Cardiac Structure and Function of Chronic Kidney Disease Patients without Dialysis

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2015FB054); 云南省教育厅科学研究基金资助项目 (2015C031Y);

Received Date: 2017-05-11

Abstract

Abstract

Objective To study the changes of myocardial injury markers hs-c Tn T, NT-pro BNP and CK-MB levels in CKD patients without dialysis in different stags and their value for outcome prediction. Methods A total of 137 cases of non-dialysis patients with chronic kidney disease were enrolled in this cross-sectional study.The myocardial injury markers hs-c Tn T, NT-pro BNP, CK-MBH and cardiac ultrasonography were examined. And the area under ROC was measured and compared to evaluate the value of different biomarkers in predicting cardiac dysfunction and outcome. Results The levels of plasma hs-c Tn T, NT-pro BNP and CK-MB in CKD5 group were the highest in the three groups, and the biomarlers in CKD3-4 group was significantly higher than CKD1-2 group (P<0.001) . The expression of LVH and the E/A <1, LVH in CKD5 group and CKD3-4 group were lower than CKD1-2 (P<0.001) .The levels of plasma hs-c Tn T, NT-pro BNP and CK-MB in the patients with CKD were measured and the left ventricular hypertrophy was evaluated by the curve of the working curve of the subjects.Through the ROC curve, the CK-MB had the highest accuracy of left ventricular hypertrophy, followed by NT-pro BNP and hs-c Tn T. Conlusions Levels of hs-c Tn T, NT-pro BNP and CK-MB are elevated in patients with CKD. CK-MB is a good biomarker in predicting cardic dysfunction of CKD patients with early cardiovascular disease.
- Chronic kidney disease,
- hs-cTnT,
- NT-proBNP,
- CK-MB,
- Echocardiography

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References(22)

References

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