Volume 38 Issue 10
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Article Navigation >  Journal of Kunming Medical University  > 2017  >  38(10): 6-10
Yuan YANG, Li-jia PENG, Lan-qing PU, Jun-jie LI, Jian-lin SHAO, Xin YANG. Application of Propofol Combined with Dexmedetomidine or Midazolam in Painless Gastrointestinal Endoscopy in the Elderly[J]. Journal of Kunming Medical University, 2021, 42(2): 43-48. doi: 10.12259/j.issn.2095-610X.S20210221
Citation: Yang Jin Feng , Meng Guo Yi , Sui Nian Han , Bian Li Gong , Hong Shi Jun , Li Li Hua , Zhao Yong Na . Effects of Methamphetamine on the Expression of DA, 5-HT and TNF-α in Rats Hippocampus[J]. Journal of Kunming Medical University, 2017, 38(10): 6-10.
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Effects of Methamphetamine on the Expression of DA, 5-HT and TNF-α in Rats Hippocampus

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基金： 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2014FB018);

  • Received Date: 2017-04-21
    Abstract
  • Objective To study the effect of methamphetamine on the expression of DA, 5-HTand TNF-αin rats hippocampus. Methods (1) The in vivo toxicity model was established by injecting MA 15 mg/ (kg.time) , two times a day for 5 days. The in vitro toxicity model was established by incubating MA with mixed hippocampal neurons/microglia for 24 hours. (2) ELISA was used to detect the content of DA, 5-HT and TNF-α in rat hippocampus and cell culture supernatant. Results On the fifth day, Methamphetamine treated rats showed hair errecting, weight loss, rapid head shaking, circling or head dorsal movement, with a stereotyped score of 5. The levels of DA and 5-HT decreased, and the content of TNF-alpha elevated in rats hippocampus of MA group. The levels of DA, 5-HT decreased and the content of TNF-alpha increased in cell cultural supernatants of MA group24 hours. Conclusion The changes of DA, 5-HT and TNF-alpha are involved in rat hippocampal damage induced by methamphetamine.
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    • References(20)
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      沈阳化工大学材料科学与工程学院 沈阳 110142

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