Vitamin D Receptor Gene TaqI Polymorphisms and Steroid Responsiveness in Childhood Nephrotic Syndrome

Cui Kun Hua; Li Qi

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Cui Kun Hua , Li Qi . Vitamin D Receptor Gene TaqI Polymorphisms and Steroid Responsiveness in Childhood Nephrotic Syndrome[J]. Journal of Kunming Medical University, 2017, 38(10): 60-64.

Citation:

Cui Kun Hua , Li Qi . Vitamin D Receptor Gene TaqI Polymorphisms and Steroid Responsiveness in Childhood Nephrotic Syndrome[J]. Journal of Kunming Medical University, 2017, 38(10): 60-64.

Cui Kun Hua , Li Qi . Vitamin D Receptor Gene TaqI Polymorphisms and Steroid Responsiveness in Childhood Nephrotic Syndrome[J]. Journal of Kunming Medical University, 2017, 38(10): 60-64.

Citation:

Cui Kun Hua , Li Qi . Vitamin D Receptor Gene TaqI Polymorphisms and Steroid Responsiveness in Childhood Nephrotic Syndrome[J]. Journal of Kunming Medical University, 2017, 38(10): 60-64.

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Vitamin D Receptor Gene TaqI Polymorphisms and Steroid Responsiveness in Childhood Nephrotic Syndrome

Cui Kun Hua ,
Li Qi

Funds:

基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (AFRP2014);

Received Date: 2017-05-10

Abstract

Abstract

Objective To determine the frequency of gene and the association of VDR gene polymorphismswith nephrotic syndrome (NS) and steroid responsiveness in Yun Nan children, so as to guide the use of hormone and immune inhibitor in this disease.Methods The subjects of the study were the 70 cases of children with nephrotic syndrome in pediatrics in the first affiliated hospital of kunming medical university from2015, May to 2016, November. Genotypes of the VDR TaqI gene polymorphism were analyzed using the PCR amplification product enzyme and agarose gel electrophoresis.Results A total of 70 NS (42 steroid sensitive [SS]and 28 steroid resistant [SR]) patientswith a mean age of 9.14 ±3.80 years were studied. The TT genotypeof VDR-TaqI polymorphism was detected in 57.1% of the SS patients compared to 57.1% of SR patients (P=1.000) .The Tt genotype was detected in 26.2% of SS patientscompared to 25.0% of SR patients (P =0.911) . The tt genotype was detected in 16.7% of SS patients compared to 17.9% of SR patients (P =0.897) . The T-allele frequency was 70.2% in SS patients compared to 69.6% of SR patients.The t-allele frequency was 29.8% in SS patients compared to 30.4% of SR patients (P =0.096) .No significant difference was detected in terms of VDR-Apal polymorphism in SS patients compared to SR patientsfor all the three genotypes (P =1.000, P =0.911, and P=0.897) . No significant difference was found in any of the allele frequencies between SS and SR (P =0.096) .Conclusion Vitamin D Receptor Gene TaqI polymorphisms has no correlation with the steroid responsiveness in childhood nephrotic syndrome.
- Nephrotic syndrome,
- Steroid sensitive,
- Steroidresistant,
- Vitamin D receptors TaqI gene polymorphism

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References(24)

References

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