Influence of Tranexamic Acid Combined with Epinephrine on Blood Loss and Knee Function Recovery of Patients with Total Knee Arthroplasty

Peng Zhong Hong; Liu Jing Song; Li Xi; Li Gen Tao; Pang Jia Ning

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Peng Zhong Hong , Liu Jing Song , Li Xi , Li Gen Tao , Pang Jia Ning . Influence of Tranexamic Acid Combined with Epinephrine on Blood Loss and Knee Function Recovery of Patients with Total Knee Arthroplasty[J]. Journal of Kunming Medical University, 2017, 38(10): 83-89.

Citation:

Peng Zhong Hong , Liu Jing Song , Li Xi , Li Gen Tao , Pang Jia Ning . Influence of Tranexamic Acid Combined with Epinephrine on Blood Loss and Knee Function Recovery of Patients with Total Knee Arthroplasty[J]. Journal of Kunming Medical University, 2017, 38(10): 83-89.

Citation:

Peng Zhong Hong , Liu Jing Song , Li Xi , Li Gen Tao , Pang Jia Ning . Influence of Tranexamic Acid Combined with Epinephrine on Blood Loss and Knee Function Recovery of Patients with Total Knee Arthroplasty[J]. Journal of Kunming Medical University, 2017, 38(10): 83-89.

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Influence of Tranexamic Acid Combined with Epinephrine on Blood Loss and Knee Function Recovery of Patients with Total Knee Arthroplasty

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2013FB144);

Received Date: 2017-05-17

Abstract

Abstract

Objective To investigate the effects of intravenous infusion of tranexamic acid (TXA) combined with epinephrine (EPI) on the early functional recovery of joints of patients with total unilateral artificial knee arthroplasty (TKA) . Methods A total of 122 patients with unilateral TKA treated with orthopedic treatment from February 2015 to December 2016 in Kunming Medical University were selected as the subjects. The random number table was used to divided them into four groups according to different methods. TXA + EPI group (n=31) :intravenous infusion of tranexamic acid (10 mg/kg) was given 10 min before the hemostatic tourniquet, and 50 ml (1: 200 000) of adrenaline dilution was injected into the joint cavity before the end of the suture capsule. (n=31) : intravenous infusion of tranexamic acid (10 mg/kg) was given to the tourniquet 10 min before the hemostatic tourniquet, and the drainage tube was clamped for 2 hours. The EPI group (n=30) : only after the injection of drainage tube 2 h (1: 200 000) , injection of the drainage tube after injection of 2 h;control group (n=30) :only after the closure of the drainage tube 2 h. The operative time, total blood loss, postoperative drainage volume, occult blood loss, postoperative blood transfusion rate, postoperative blood transfusion rate, postoperative thickness of 10 cm on patellar and patellofemps were observed on 3 to 5 days postoperation. The deep vein thrombosis7 d after surgery was observed by lower extremity vascular ultrasound examination, and patients were followed up for3 months. Rsults Four patients in the TXA + EPI group had an incisional healing and extended to 3 weeks. The remaining three groups of patients were wound healing, 2 weeks or so stitches. There was no significant difference in the HSS score between the four groups (P>0.05) . TXA + EPI group, TXA group, EPI group (P<0.05) , but there was no significant difference between the two groups (P <0.05) , but there was no significant difference between the two groups (P<0.05) , but the total blood loss, postoperative drainage volume, hidden blood loss, postoperative blood transfusion rate (P<0.05) . There was no significant difference between the EPI group and the rest group (P>0.05) . The level of TXA + EPI in the EPI group was higher than that in the other three groups (P>0.05) (P<0.05) Conclusion Tranexamic acid combined with adrenaline can significantly reduce the first unilateral artificial TKA postoperative blood loss, reduce the knee swelling after TKA, and promote the patient's early knee functional exercise, accelerate knee function recovery, there is a certain application value, but may cause delayed wound healing and other complications, clinical application need to be cautious.
- Tranexamic acid,
- Epinephrine,
- Total knee arthroplasty,
- Blood loss,
- Knee activity

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References(29)

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