Effects of Osteoking on Estradiol and Bone Metabolism of Tree Shrews with Osteoporotic Fracture

Li Jin Tao; Zheng Hong; Li Bo; Yuan Xin; Tang Wei; Zhao Hong Bin

Article Contents

Article Navigation > Journal of Kunming Medical University > 2017 > 38(11): 15-18

Li Jin Tao , Zheng Hong , Li Bo , Yuan Xin , Tang Wei , Zhao Hong Bin . Effects of Osteoking on Estradiol and Bone Metabolism of Tree Shrews with Osteoporotic Fracture[J]. Journal of Kunming Medical University, 2017, 38(11): 15-18.

Citation:

Li Jin Tao , Zheng Hong , Li Bo , Yuan Xin , Tang Wei , Zhao Hong Bin . Effects of Osteoking on Estradiol and Bone Metabolism of Tree Shrews with Osteoporotic Fracture[J]. Journal of Kunming Medical University, 2017, 38(11): 15-18.

Citation:

PDF( 309 KB)

Effects of Osteoking on Estradiol and Bone Metabolism of Tree Shrews with Osteoporotic Fracture

Funds:

基金：国家自然科学基金资助项目 (81460647); 云南省应用基础研究计划项目 (2012FB022, 2013FZ072, 2014FB033); 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2017FE467 (-128) ];

Received Date: 2017-09-11

Abstract

Abstract

Objective To observe the effects of Osteoking on serum estradiol and bone metabolism index of tree shrew with osteoporotic fracture.Methods Tree shrews with osteoporotic fracture were randomly divided into treatment group and control group.The tree shrews in treatment group were given 0.3 mL of Osteoking by 100 g body weight every two days for 90 days, while the tree shrews in the control group were given the same dose of saline.The serum samples were collected from the heart.The contents of E2, OC, PINP, CTX and TRACP-5 b were measured by ELISA kit.Results The serum E2 content of tree shrews in the treatment group was significantly higher than the control group (145.16±21.76 vs 30.78±4.22) (P<0.05) , the serum OC (1546.67±219.07) , PINP (10.02±1.76) , CTX (176.47±24.56) , TRACP-5 b (1249.06±194.87) in the treatment group were significantly lower than the control group (2792.96±387.23) and (28.74±4.05) , (324.67±41.32) , (2106.36±322.99) (P<0.05) .Conclusion Osteoking can cause changes in estradiol and bone metabolism index of tree shrews with osteoporotic fracture, indicating it has a certain effect
- Osteoking,
- Osteoporosis,
- Fracture,
- Tree shrew,
- Estradiol,
- Bone metabolism

FullText(HTML)

References(17)

References

[1]胡敏, 王兵, 赵宏斌, 等.恒古骨伤愈合剂预防性给药对股骨颈骨折术后半年股骨头坏死发生率及负重髋疼痛程度的影响[J].中国临床康复, 2005, 9 (14) :158-159.
[2]赵宏斌, 胡敏, 邱智兴, 等.恒古骨伤愈合剂治疗腰椎间盘突出症37例长期疗效观察[J].云南中医中药杂志, 2006, 27 (5) :3-4.
[3]周兆文, 普有登, 袁晓峰, 等.恒古骨伤愈合剂治疗急性腰扭伤的疗效观察[J].云南医药, 2012, 33 (5) :435-436.
[4]	[4]YOUNG P A.Treeshrews, the primitive primate mammals for medical experimental animals[J].Int'l J Mol Zoo, 2011, 1 (2) :4-6.
[5]杨凤, 李燕皎, 王运林, 等.手术双侧卵巢去势法建立骨质疏松树模型[J].昆明医科大学学报, 2016, 37 (1) :24-27.
[6]中国老年学学会骨质疏松委员会.中国人骨质疏松症诊断标准专家共识 (第三稿2014版) [J].中国骨质疏松杂志, 2014, 20 (9) :1007-1010.
[7]吴婷婷, 屈会化, 胡丽娜, 等.基于树体表面积的树与人类及其它实验动物等效剂量换算系数的测算[J].中华中医药杂志, 2015, 30 (1) :203-205.
[8]孙岩, 陈冉, 王小琦, 等.恒古骨伤愈合剂对去势雌性大鼠骨质疏松模型的影响[J].中国骨质疏松杂志, 2016, 22 (12) :1513-1515.
[9]李冠慧, 李灿东, 李西海, 等.雌激素调控绝经后骨质疏松症骨吸收-骨形成耦联失衡的机制[J].中医正骨, 2016, 28 (2) :36-39.
[10]薛吴罡, 冷冰, 马恩元, 等.雌激素水平与绝经女性并发骨质疏松症的相关性研究[J].中国妇幼保健, 2011, 26 (26) :4106-4108.
[11]李丹, 孙文艳, 李晶, 等.老年骨质疏松患者骨折与骨代谢标志物的相关性研究[J].临床医药实践, 2015, 24 (7) :500-504.
[12]	[12]KLINGBERG E, NURKKALA M, CARLSTEN H, et al.Biomarkers of bone metabolism in ankylosing spondylitis in relation to osteoproliferation and osteoporosis[J].J Rheumatol, 2014, 41 (7) :1349-1356.
[13]樊险峰, 黄兴华, 黄运咏, 等.鲑鱼降钙素治疗骨质疏松症的疗效及对骨代谢标志物水平的影响[J].海南医学院学报, 2015, 21 (8) :1137-1139.
[14]黄继红, 李溥, 任一, 等.鹿角壮骨胶囊对去卵巢骨质疏松大鼠骨细微结构及骨代谢影响的实验研究[J].基层医学论坛, 2016, 20 (7) :865-868.
[15]孔西建, 吴丹, 叶进, 等.益肾活血法对原发性骨质疏松症患者骨密度、骨代谢及脆性骨折发生率的影响[J].中医杂志, 2014, 55 (5) :391-395.
[16]覃裕, 邱冰, 朱思刚, 等.仙灵骨葆胶囊治疗骨质疏松症的疗效及其对骨代谢及骨转换指标的影响分析[J].中国骨质疏松杂志, 2015, 21 (9) :1056-1060.
[17]刘冬梅, 袁林, 苏林冲, 等.强骨康疏胶囊对去卵巢骨质疏松症模型大鼠细胞因子的影响[J].中国免疫学杂志, 2014, 30 (3) :338-341.

Relative Articles(20)

Relative Articles

[1]	Chenrong JIANG, Xuanran ZHOU, Long PU, Yong YUAN. The Efficacy of Two Operative Approaches of Hemiarthroplasty in the Treatmemt of Intertrochanteric Fracture in Elderly Patients. Journal of Kunming Medical University, 2024, 45(1B): 1-6.
[2]	Leijing RAN, Shaohua WANG, Lintong LI, Li GUI. A Meta-analysis of the Effect of Adjuvant Probiotics in Patients with Osteoporosis. Journal of Kunming Medical University, 2024, 45(2): 65-76. doi: 10.12259/j.issn.2095-610X.S20240209
[3]	Jingyu YAO, Rui WEI, Lin ZHANG, Shengliu SHI, Peng BAI. The Effects of NLR，PLR，and FRA in Peripheral Blood on Normal Bone Mass and Bone Loss after Fractures. Journal of Kunming Medical University, 2024, 45(11): 125-129. doi: 10.12259/j.issn.2095-610X.S20241117
[4]	Yongyi ZOU, Zhiye QI, Dongmei SUN, Chunmei Wan, Kun LIANG. Effects of Different Vitamin D Doses on Bone Metabolism and Growth and Development Indicators of Preterm infants：A Cohort Study. Journal of Kunming Medical University, 2023, 44(11): 76-81. doi: 10.12259/j.issn.2095-610X.S20231111
[5]	Shaoyou DENG, Rong LI, Jintao LI, Yulan ZHAO, Peijin WANG, Hong ZHENG. Mechanism of Osteoking Improving Osteoarthritis based on Network Pharmacology and DDM Rats. Journal of Kunming Medical University, 2023, 44(7): 34-39. doi: 10.12259/j.issn.2095-610X.S20230701
[6]	Shaoyou DENG, Yulan ZHAO, Peijin WANG, Rong LI, Jintao LI, Hong ZHENG. Effects of Osteoking Combined with Antibiotic Cocktail on Insulin Resistance and Gut Flora in db/db Mice. Journal of Kunming Medical University, 2023, 44(5): 12-18. doi: 10.12259/j.issn.2095-610X.S20230530
[7]	Yong LIAO, Yi-yun GUO, Hong-yu ZHOU, Hai-po FENG, Gen-ding CHEN, Shui-qing YANG. Effects of Folic Acid Combined with Alendronate on Bone Metabolism，CCl4 and Fibroblast Growth Factor Levels in Postmenopausal Osteoporosis Patients. Journal of Kunming Medical University, 2021, 42(7): 98-103. doi: 10.12259/j.issn.2095-610X.S20210716
[8]	Yu-wei JI, Xin ZHAO, Jiang-li LU, Yi YANG, Wei TANG, Jian-lin JIAO. Effect of Osteoking on Bone Density and Bone Biomechanics of Tree Shrews in a Postmenopausal Osteoporotic Fracture Model. Journal of Kunming Medical University, 2020, 41(11): 7-11. doi: 10.12259/j.issn.2095-610X.S20201103
[9]	Li Li , Zeng Yue Qin , Li Jin Tao , Zhao Hong Bin , Liang Zhang , Wang Li Mei . . Journal of Kunming Medical University, 2019, 40(07): 15-18.
[10]	Li Li , Li Jin Tao , Guo Yu Qing , Wu Chao , Lu Jiang Li , Zeng Yue Qin , Jiao Jian Lin . . Journal of Kunming Medical University, 2019, 40(06): 6-10.
[11]	Du Shi Gang , Zhao Ling , Pu Meng Xian , Pan Yi , Du Juan , Ke Ting Yu . . Journal of Kunming Medical University, 2018, 39(12): 43-48.
[12]	Zheng Hong , Li Jin Tao , Yuan Xin , Wu Chao , Zeng He , Zhao Hong Bin , Tang Wei . Osteoking Promotes the Proliferation of BMSC through Activating TGF-β/Smad Signaling Pathway in Castrate Osteoporosis Rats. Journal of Kunming Medical University, 2018, 39(03): 5-10.
[13]	Li Jin Tao , Zheng Hong , Tang Wei , Wu Chao , Jiao Jian Lin , Zhao Hong Bin . Effects of Different Feeding Space on Estradiol and Bone Metabolism Index in Tree Shrews with Osteoporosis. Journal of Kunming Medical University, 2017, 38(09): 1-6.
[14]	Yuan Xin , Zheng Hong , Jiao Jian Lin , Wu Chao , Zhao Hong Bin , Tang Wei . Effect of Osteoking on Blood Biochemical Indicator of Tree Shrew with Osteoporotic Fracture. Journal of Kunming Medical University, 2017, 38(07): 12-15.
[15]	Zhao Zheng Xing . Clinical Efficacy of PFNA Internal Fixation in the Treatment of 40 Osteoporotic Intertrochanteric Fractures. Journal of Kunming Medical University,
[16]	Yao Rong Cheng . . Journal of Kunming Medical University,
[17]	Yu Le . . Journal of Kunming Medical University,
[18]	Lv Tao . . Journal of Kunming Medical University,
[19]	Ma Lan . . Journal of Kunming Medical University,
[20]	Zhang Xiao Chao . . Journal of Kunming Medical University, 2012, 33(08): 1-1.