Effect of Left Ventricle Reconstruction on Left Ventricular Remolding

Bai Xiang Feng; Tao Jie; Meng Jun; Yang Wei

Volume 38 Issue 11

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Bai Xiang Feng , Tao Jie , Meng Jun , Yang Wei . Effect of Left Ventricle Reconstruction on Left Ventricular Remolding[J]. Journal of Kunming Medical University, 2017, 38(11): 34-39.

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Bai Xiang Feng , Tao Jie , Meng Jun , Yang Wei . Effect of Left Ventricle Reconstruction on Left Ventricular Remolding[J]. Journal of Kunming Medical University, 2017, 38(11): 34-39.

Bai Xiang Feng , Tao Jie , Meng Jun , Yang Wei . Effect of Left Ventricle Reconstruction on Left Ventricular Remolding[J]. Journal of Kunming Medical University, 2017, 38(11): 34-39.

Citation:

Bai Xiang Feng , Tao Jie , Meng Jun , Yang Wei . Effect of Left Ventricle Reconstruction on Left Ventricular Remolding[J]. Journal of Kunming Medical University, 2017, 38(11): 34-39.

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Effect of Left Ventricle Reconstruction on Left Ventricular Remolding

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基金：云南省教育厅科学研究基金资助项目 (5J0347C);

Received Date: 2017-05-22

Abstract

Abstract

Objective To investigate the effect of left ventricular reconstruction on left ventricular remolding.Methods We selected twelve common dogs as experimental animals.We ligated the aeteria coronaria and established the model of ventricular aneurysm.We seleced the normal cardiac muscle as common group.After modelling and evaluating, the dogs of successful modelling were divided into two groups.The experimental group was rebuilt by the operation of left ventricular reconstruction (linear closure operation) .The control group was disclosed chest, yet it was not rebuilt by the operation of left ventricular (linear closure operation) ;after six weeks of the operation of left ventricular reconstruction, we obtained the cardiac muscle of nonoperating field in every group.Then we detected the content of AT1R mRNA, AT2Rm RNA of the cardiac muscle of every group by RT-PCR and observed ultrastructure of the cardiac muscle of every group by electron microscope.Results Compared with normal group, the expression of AT2R mRNA was significantly higher (P<0.05) , the expression of AT1R mRNA was significantly lower (P<0.05) , and AT2R mRNA/AT1R mRNA ratio was significantly higher (P<0.05) in experimental group and the control group.Compared with control group, the expression of AT2R mRNAwas significantly lower (P<0.05) , the expression of AT1R mRNA was significantly higher (P<0.05) , and AT2R mRNA/AT1R mRNA ratio was significantly lower (P<0.05) in experimental group;Compared with the common group, ventricular remolding (collagen protein obviously deposited in the mesenchyme of cardiac muscle, collagen fibers became obviously larger) and cardiac damage (the gap of myofibrilla became larger in myocardial cell, cytoplasm dropsy, the part of mitochondria cristas was broken) ultramicrostructure took place in the cardiac muscle of the experimental group and the control group;compared with the control group, the extent of ventricular remolding and Cardiac damage of experimental group was less than the control group in the electron microscope.Conclusion Left ventricular reconstruction (linear closure operation) can delay the process of left ventricular remolding to a certain extent, lower the extent of cardiac damage and help to prevent the development of ventricular remolding and improve the prognosis of ventricular remolding.

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References

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