Effect of Dexmedetomidine on Brain Edema in Rats with Severe Traumatic Brain Injury

Li Zheng Chao; Qian Chuan Yun; Wu Hai Ying; Zhang Wei; Xia Jing

Volume 38 Issue 11

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Li Zheng Chao , Qian Chuan Yun , Wu Hai Ying , Zhang Wei , Xia Jing . Effect of Dexmedetomidine on Brain Edema in Rats with Severe Traumatic Brain Injury[J]. Journal of Kunming Medical University, 2017, 38(11): 40-44.

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Effect of Dexmedetomidine on Brain Edema in Rats with Severe Traumatic Brain Injury

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基金：云南省教育厅科学研究基金资助项目 (2014J043);

Received Date: 2017-03-01

Abstract

Abstract

Objective To study the effect of dexmedetomidine on brain edema in rats with severe traumatic brain injury (TBI) .Methods SD rat traumatic brain injury model was established and was treated with dexmedetomidine.The changes of neurological impairment, brain water content and BBB permeability were observed within 72 hours after injury.Results The NSS score of different TBI rats in different groups:the difference of internal effect was statistically significant (P=0.041) , and the difference between subjects was statistically significant (P<0.001) .The water content of the brain tissue in different groups of TBI rats was statistically significant (P=0.032) , and the difference between subjects was statistically significant (P<0.001) .The correlation was found between neurological score and cerebral edema degree (r=0.61, P<0.001) .Conclusions TBI rat cerebral edema peaks at 24 h after TBI.Dexmedetomidine can reduce BBB permeability and reduce the edema of TBI rats in the early stage of injury, thereby promoting the recovery of nerve function.
- Traumatic brain injury,
- Brain edema,
- Dexmedetomidine

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References(20)

References

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