Correlation Between Vitamin D Receptor (VDR) TaqIGene Polymorphism and Bone Metabolism Disorder in Children, s Nephrotic Syndrome

Cui Kun Hua; Li Qi

Volume 38 Issue 11

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Cui Kun Hua , Li Qi . Correlation Between Vitamin D Receptor (VDR) TaqIGene Polymorphism and Bone Metabolism Disorder in Children, s Nephrotic Syndrome[J]. Journal of Kunming Medical University, 2017, 38(11): 69-74.

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Correlation Between Vitamin D Receptor (VDR) TaqIGene Polymorphism and Bone Metabolism Disorder in Children, s Nephrotic Syndrome

Cui Kun Hua ,
Li Qi

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (AFRP2014);

Received Date: 2017-05-20

Abstract

Abstract

Objective In this paper, we study the relationship between vitamin D receptor TaqIgene polymorphism and bone metabolism disorder in children, snephrotic syndrome, in order to predict children's risk of osteoporosisaccording to the genetic polymorphisms, guiding drug treatment and evaluating the effect of drug treatment.Methods The object of the study was the 70 cases of children with nephrotic syndrome in pediatrics in the first affiliated hospital of Kunming Medical University from May 2015 to November 2016.Genotypes of the VDR TaqI gene polymorphism were analyzed using the PCR amplification product enzyme and agarose gel electrophoresis, bone metabolic markers with biochemical analysis.Results The F value of calcitonin (CT) .25 (OH) D3 (VIT-D) .parathyroid hormone (PTH) .Calcium (Ca) .phosphorus (P) .alkaline phosphatase (ALP) in the three genotypes (TT TT TT) of vitamin D receptor TaqI gene polymorphism were:0.574, 2.973, 1.947, 2.566, 0.423, 0.242, P>0.05.The F value of magnesium (Mg) was 9.278, P<0.001.In children with TT genotype, after calcitriol treatment2 weeks, the t value of calcitonin.25 (OH) D3.parathyroidhormone.magnesium.phosphorus.alkaline phosphatase were:0.796, 0.290, 0.295, 0.574, 0.830, 0.933, P >0.05 compared with treatment before.The t value of Ca was 4.301, P<0.001.In children with Tt genotype, the t value of calcitonin.25 (OH) D3.parathyroid hormone.calcium.magnesium.phosphorus.alkaline phosphatase were:0.722, 1.298, 1.391, 1.511, 1.671, 1.045, 0.368, P>0.05.In children with tt genotype, the t value of calcitonin.25 (OH) D3.parathyroid hormone.magnesium.phosphorus.alkaline phosphatase were:1.168, 1.755, 1.787, 2.344, 1.777, 1.808, P>0.05;the t value of Ca was 2.458, the P<0.005.Conclusions In children with nephrotic syndrome, vitamin D receptor TaqI gene polymorphism can assess the risk of osteoporosis, tt genotype has lower risk of osteoporosis as compared with Tt genotype and TT genotype.TT genotype and tt genotype have better reactivity of calcitriol therapy.Serum calcium is significantly elevated after 2 weeks' treatment of calcitriol.The risk for osteoporosis is significantly reduced.
- Vitamin D receptor,
- TaqI gene polymorphism,
- Nephrotic syndrome in children,
- Bone metabolic markers,
- Calcitriol

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