Application of Related Laboratory Indexes in Early Rheumatoid Arthritis

Pan Bao Long; Wu Ling; Pan Li; Zhang Yuan Yuan; Li Jun E; Zhan Xue Liang

Volume 38 Issue 11

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Pan Bao Long , Wu Ling , Pan Li , Zhang Yuan Yuan , Li Jun E , Zhan Xue Liang . Application of Related Laboratory Indexes in Early Rheumatoid Arthritis[J]. Journal of Kunming Medical University, 2017, 38(11): 96-100.

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Pan Bao Long , Wu Ling , Pan Li , Zhang Yuan Yuan , Li Jun E , Zhan Xue Liang . Application of Related Laboratory Indexes in Early Rheumatoid Arthritis[J]. Journal of Kunming Medical University, 2017, 38(11): 96-100.

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Application of Related Laboratory Indexes in Early Rheumatoid Arthritis

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基金：云南省高层次卫生技术人才专项基金资助项目 (D-201206);

Received Date: 2017-06-17

Abstract

Abstract

Objective To evaluate the current related laboratory indicators of rheumatoid arthritis (RA) and screening out the optimal early RA-related indicators.Methods We selected 158 cases as RA group, 121 cases as early RA group, 100 cases as normal control group.The total rheumatoid factor and other 14 indicators were measured and analyzed statistically in each group.No statistical differences indicators were observed, the ROC curve was used to evaluate the diagnostic efficacy of the remaining indicators in early RA, AUC>0.75 as the standard, indicators with diagnostic efficacy were initially screened.The sieve out indicators were used for bivariate correlation analysis, significant correlates are classified as a same class.Results (1) Among the 14 indicators, except for RF IgA and CRP, the other indexes were significantly different in the three groups (P<0.05) .There were 6 indexes which exceeding 0.75 of area under the single index curve (AUC) :GPI (0.929) , anti-MCV (0.923) , RF IgG (0.904) , anti-CCP (0.901) , APF (0.891) and total RF (0.880) ; (3) By bivariate correlation analysis, there was a significant positive correlation between the six indexes and whether they were early RA, and classified as 3 groups:GPI group, anti-MCV group (including anti-CCP and APF) , RF IgG group (including total RF) .Conclusion In the 14 indicators, only 6 indicators (GPI class, anti-MCV class and RF IgG class) have higher diagnostic efficacy for early RA, we only need to choose one to carry out in each category in practice, so as to avoid clinical and laboratory duplication or low-performance testing.
- Rheumatoid arthritis,
- Early diagnosis,
- Autoantibody,
- Diagnostic efficacy

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