The Effect of Oxaliplatin Injection Combined with S-1 on Levels of CEA, CA199, TAM and the Quality of Life of Patients with Advanced Gastric Cancer

Jiang Bo; Lin Chao

Article Contents

Article Navigation > Journal of Kunming Medical University > 2018 > 39(01): 113-117

Jiang Bo , Lin Chao . The Effect of Oxaliplatin Injection Combined with S-1 on Levels of CEA, CA199, TAM and the Quality of Life of Patients with Advanced Gastric Cancer[J]. Journal of Kunming Medical University, 2018, 39(01): 113-117.

Citation:

Jiang Bo , Lin Chao . The Effect of Oxaliplatin Injection Combined with S-1 on Levels of CEA, CA199, TAM and the Quality of Life of Patients with Advanced Gastric Cancer[J]. Journal of Kunming Medical University, 2018, 39(01): 113-117.

Citation:

PDF( 241 KB)

The Effect of Oxaliplatin Injection Combined with S-1 on Levels of CEA, CA199, TAM and the Quality of Life of Patients with Advanced Gastric Cancer

Jiang Bo ¹,
Lin Chao ²

Funds:

基金：四川省卫生厅科研基金资助项目 (1201971);

Received Date: 2017-09-21

Abstract

Abstract

Objective To investigate the effect of oxaliplatin injection combined with S-1 on levels of carcinoembryonic antigen (CEA) , cancer antigen 199 (CA199) and tumor associated materials (TAM) and the quality of life of patients with advanced gastric cancer. Methods The clinical data of 70 patients with advanced gastric cancer treated in our hospital from January 2013 to June 2016 were retrospectively analyzed. According to different chemotherapy regimens, the patients were divided into the study group (n = 35, treated with oxaliplatin injection combined with S-1) and the control group (n = 35, treated with S-1) . The short-term curative effect in the two groups was evaluated, and levels of serum tumor markers were detected before and after the treatment.The toxicity and quality of life were evaluated. Results The total effective rate of treatment and disease control rate in the study group were significantly higher than those in the control group (45.71% and 88.57% vs 2.86% vs71.43%) (P < 0.05) . There were no significant differences in levels of serum CEA, CA199 and TAM between the two groups before the treatment (P > 0.05) . After the treatment, levels of serum CEA, CA199 and CEA were significantly decreased (P < 0.05) , and the decrease was significantly greater in the study group than in the control group (P < 0.05) . During and after the treatment, nausea and vomiting was more severe in the study group than in the control group (P < 0.05) , while the incidence rates of neutropenia, thrombocytopenia, peripheral neuritis and liver or kidney function damage showed no statistically significant difference (P > 0.05) . After the treatment, the improvement rate of KPS score in the study group was significantly higher than that in the control group (60% VS 31.42%) , and the overall improvement of the quality of life was significantly better than that in the control group (P < 0.05) . Conclusion Oxaliplatin injection combined with S-1 can effectively inhibit the growth and metastasis of tumor cells, remit the condition and improve the clinical efficacy with high safety in patients with advanced gastric cancer. It also can improve the quality of life of patients.
- Oxaliplatin injection,
- S-1,
- Advanced,
- Gastric cancer,
- CEA,
- CA199,
- TAM,
- Quality of life

FullText(HTML)

References(14)

References

[1]朱洁品, 娄金书.生长抑素联合多西他赛和替吉奥治疗进展期胃癌的临床研究[J].现代药物与临床, 2017, 32 (1) :124-128.
[2]智俊娜, 吴婷婷, 赵本慧, 等.替吉奥联合奥沙利铂与替吉奥联合多西他赛治疗晚期胃癌的临床观察[J].成都医学院学报, 2014, 9 (1) :34-37.
[3]芦兰, 许绿叶, 师幸伟.自体CIK细胞对晚期胃癌肿瘤标志物及生活质量的影响[J].广东医学, 2014, 35 (5) :698-700.
[4]中华人民共和国卫生部.中华人民共和国卫生行业标准:胃癌诊断标准 (WS 316-2010) [M].北京:中国标准出版社, 2010:353.
[5]陈智伟, 廖美琳.RECIST标准在肿瘤治疗疗效评价中的应用[J].中国肿瘤, 2004, 13 (10) :616-618.
[6]汪正广, 齐东江, 李嘉嘉, 等.中晚期胃癌患者术后化疗联合黄芪颗粒治疗对生活质量及免疫功能的影响[J].安徽医科大学学报, 2014, 49 (12) :1771-1774.
[7]韩茜, 李五生, 陈卫东, 等.替吉奥联合健脾丸对老年结直肠癌转移患者血清肿瘤标志物、COX-2及MMP-2水平影响研究[J].中华中医药学刊, 2016, 34 (11) :2734-2737.
[8]	[8]KIM J H, JUN KHJUNG H.Prognostic value of preoperative serum levels of five tumor markers (carcinoembryonic antigen, CA19-9, Alpha-fetoprotein, CA72-4, and CA125) in uastric cancer[J].Hepatogastroenterology, 2014, 61 (131) :863-869.
[9]	[9]LEE E C, YANG J Y, LEE K G, et al.The value of postoperative serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels for the early detection of gastric cancer recurrence after curatme resection[J].Gastric Cancer, 2014, 14 (4) :221-228.
[10]	[10]HUANG Z B, ZHOU X, XU J, et al.Prognostic value of preopera tme serum tumor markers in gastric Cancer[J].World J Clin Oncol, 2014, 5 (2) :170-176.
[11]刘云军, 何志江, 黄毅超, 等.替吉奥联合奥沙利铂对晚期胃癌患者TAM、CEA、CA72-4的影响[J].实用癌症杂志, 2014, 29 (5) :506-508.
[12]吴福道, 张小静, 蔡辉, 等.替吉奥联合奥沙利铂治疗晚期胃癌的临床疗效观察[J].重庆医学, 2015, 44 (13) :1835-1837.
[13]涂德军, 洪俊强, 张启龙, 等.奥沙利铂联合S-1胶囊方案和FOLFOX6方案治疗晚期胃癌的疗效观察[J].西部医学, 2014, 26 (9) :1158-1160.
[14]张虎, 曹登科, 刘海威.奥沙利铂片联合替吉奥胶囊治疗中晚期胃癌的远期临床疗效研究[J].中国临床药理学杂志, 2016, 32 (21) :1971-1973.

Relative Articles(20)

Relative Articles

[1]	Yingbi TAO, Qiuju ZHAI, Sijia MA, Mingzhu ZHANG. Effects of Diversified Health Education on Quality of Life and Anxiety in Patients Undergoing Periodontal Accelerated Osteogenic Orthodontic Surgery. Journal of Kunming Medical University, 2024, 45(10): 173-178. doi: 10.12259/j.issn.2095-610X.S20241027
[2]	Wenni MA, Wenjuan FENG, Zilin MA, Yongshi FAN, Yi MA, Ying HUANG. The Mediating Effect of Self-management on the Discharge Readiness and Quality of Life in Patients with Type B Aortic Dissection. Journal of Kunming Medical University, 2024, 45(5): 195-200. doi: 10.12259/j.issn.2095-610X.S20240530
[3]	Yaoyao PEI, Zhangying XU, Wei XIAO, Xiuxian LI, Tingting HU. Mediating Effect of Hope on Self-perceived Burden and Quality of Life in Patients with Recurrent Malignant Tumor. Journal of Kunming Medical University, 2024, 46(): 1-6.
[4]	Jiang WU, Shuifen DAI, Qin LIU, Shoutao YANG, Jiang ZHANG, Jiao YANG, Qiongyao GUAN. Effect of Nutrition Clinical Nursing Pathway for Nasopharyngeal Carcinoma Patients Concurrent Radiotherapy and Chemotherapy. Journal of Kunming Medical University, 2023, 44(5): 185-190. doi: 10.12259/j.issn.2095-610X.S20230510
[5]	Yunhui ZHANG, Yang SUN, Xieqiao HE, Dezhi TAO, Fameng LUO, Haiyan ZHANG. Effects of Narrative Nursing on Psychological Distress and Quality of Life in Patients with Gastrointestinal Malignancies. Journal of Kunming Medical University, 2023, 44(8): 162-166. doi: 10.12259/j.issn.2095-610X.S20230810
[6]	Hong LI. Quantitative Analysis of Real-time Ultrasound Elastography in Elderly Patients with Advanced Malignant Obstructive Jaundice in Assessing the Prognosis of PTCD. Journal of Kunming Medical University, 2023, 44(2): 150-155. doi: 10.12259/j.issn.2095-610X.S20230206
[7]	Hong LI. Quantitative Analysis of Real-time Ultrasound Elastography in Elderly Patients with Advanced Malignant Obstructive Jaundice and the Assessment of Prognostic Value of PTCD. Journal of Kunming Medical University, 2023, 44(1): 122-127. doi: 10.12259/j.issn.2095-610X.S20230123
[8]	Ming JIN, Mei CEN, Lijing ZHAO. Impact of Path-based Symptom Management Education Driven by Multidisciplinary Teams on The Quality of Life of Patients with Chronic Heart Failure. Journal of Kunming Medical University, 2022, 43(11): 185-192. doi: 10.12259/j.issn.2095-610X.S20221125
[9]	Hua-ying CHEN, Wei WANG, Bao-ling LIU, Yan BAO, Lei HU. Effect of Standardized Management Model on Improving the Quality of Life of Patients with Ankylosing Spondylitis. Journal of Kunming Medical University, 2021, 42(6): 161-165. doi: 10.12259/j.issn.2095-610X.S20210605
[10]	Jiang WU, Yan-yan FEI, Shui-fen DAI, Li YANG, Qian ZHOU, Ling ZHANG, Tao SHI. Effect of Standard Nutrition Intervention on Quality of Life in Patients with Rhinitis after Radiotherapy. Journal of Kunming Medical University, 2021, 42(7): 166-169. doi: 10.12259/j.issn.2095-610X.S20210728
[11]	Ding Zhe Yu , Cun Ying Li , Cha Yong , Dai You Guo , Zhang Wen , Zhang Zhong Hong , Du Feng , Wan Chong Hua . Revision of the Quality of Life Instruments for Cancer Patients-Stomach Cancer (V 2.0). Journal of Kunming Medical University, 2017, 38(07): 50-54.
[12]	Zheng Jin Hong . . Journal of Kunming Medical University,
[13]	Wang Yuan Yuan . . Journal of Kunming Medical University,
[14]	Chi Xiu Ping . . Journal of Kunming Medical University,
[15]	Lin Zhong Ju . . Journal of Kunming Medical University,
[16]	Dang Yan Yan . . Journal of Kunming Medical University,
[17]	Yang Yan . . Journal of Kunming Medical University,
[18]	Yang Qing Rong . . Journal of Kunming Medical University,
[19]	Wu An Yue. . Journal of Kunming Medical University,
[20]	Ma Yong Hong . . Journal of Kunming Medical University,