有氧运动对2型糖尿病大鼠AGE-RAGE轴及NF-κB通路的影响

Shen Zhi Xiang; Zhu Li Xun; Xu Wei Hong

Volume 39 Issue 01

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Shen Zhi Xiang , Zhu Li Xun , Xu Wei Hong . 有氧运动对2型糖尿病大鼠AGE-RAGE轴及NF-κB通路的影响[J]. Journal of Kunming Medical University, 2018, 39(01): 16-19.

Citation:

Shen Zhi Xiang , Zhu Li Xun , Xu Wei Hong . 有氧运动对2型糖尿病大鼠AGE-RAGE轴及NF-κB通路的影响[J]. Journal of Kunming Medical University, 2018, 39(01): 16-19.

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有氧运动对2型糖尿病大鼠AGE-RAGE轴及NF-κB通路的影响

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基金：上海市长宁区科委重点基金资助项目 (CNKW2014Z03);

Received Date: 2017-10-17

Abstract

Abstract

目的研究有氧运动对2型糖尿病 (T2DM) 大鼠AGE-RAGE轴及NF-κB通路的影响, 探讨T2DM运动康复作用.方法 8周龄雄性Wister大鼠高糖高脂饮食后, 应用链脲佐菌素诱导建立T2DM大鼠.将30只造模成功的T2DM大鼠随机分成3组 (n=10) :T2DM组、T2DM加低强度运动组 (T2DML) 和T2DM加中强度运动组 (T2DMM) .运动组实施运动方案.采用ELISA法分别测定实验大鼠血浆、骨骼肌和心肌的晚期糖基化终产物 (AGEs) 及其受体 (RAGE) 和核因子κB (NF-κB) 水平.结果与T2DM组相比, T2DML组血、骨骼肌和心肌的NF-κB水平显著下降 (P<0.05) ;T2DMM组血、骨骼肌和心肌的AGEs、RAGE和NF-κB水平均显著下降 (P<0.05) ;与T2DML组相比, T2DMM组血、骨骼肌和心肌的NF-κB水平均显著下降 (P<0.05) .结论中强度有氧运动能抑制AGE-RAGE轴和NF-κB通路, 降低T2DM氧化应激和炎症反应, 减轻组织损伤, 对T2DM及其并发症具有防治作用.
- Type 2 diabetes mellitus,
- Aerobic exercise,
- Advanced glycation end products,
- Receptor of AGE,
- Nuclear factor-kappa B

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