Effects of Exchange Transfusion on Renal Function, Inflammatory Factors and Blood Internal Environment in Children with Hyperbilirubinemia

Qu Jing Lei; Yang Yuan Zheng

Article Contents

Article Navigation > Journal of Kunming Medical University > 2018 > 39(01): 96-99

Qu Jing Lei , Yang Yuan Zheng . Effects of Exchange Transfusion on Renal Function, Inflammatory Factors and Blood Internal Environment in Children with Hyperbilirubinemia[J]. Journal of Kunming Medical University, 2018, 39(01): 96-99.

Citation:

Qu Jing Lei , Yang Yuan Zheng . Effects of Exchange Transfusion on Renal Function, Inflammatory Factors and Blood Internal Environment in Children with Hyperbilirubinemia[J]. Journal of Kunming Medical University, 2018, 39(01): 96-99.

Citation:

Qu Jing Lei , Yang Yuan Zheng . Effects of Exchange Transfusion on Renal Function, Inflammatory Factors and Blood Internal Environment in Children with Hyperbilirubinemia[J]. Journal of Kunming Medical University, 2018, 39(01): 96-99.

PDF( 202 KB)

Effects of Exchange Transfusion on Renal Function, Inflammatory Factors and Blood Internal Environment in Children with Hyperbilirubinemia

Qu Jing Lei ¹,
Yang Yuan Zheng ²

Funds:

基金：海南省卫生计生行业科研基金资助项目 (14A210207);

Received Date: 2017-09-21

Abstract

Abstract

Objective To study the effects of exchange transfusion on renal function, inflammatory factors and blood internal environment in children with hyperbilirubinemia. Methods Neonates with hyperbilirubinemia treated in neonatal intensive care unit of the hospital between February 2015 and March 2017 were selected as the research subjects and divided into two groups by random number table method. Combined group received exchange transfusion combined with blue ray irradiation, and control group received blue ray irradiation. The serum levels of bilirubin, renal function indexes, inflammatory response indexes and oxidative stress response indexes were measured 24 hours after the treatment. Results 24 hours after the treatment, serum TBIL, BUN, Cr, β2-MG, Cys C, TRF, CRP, IL-6, TNF-α, MDA and AOPP levels of combined group were greatly lower than those of control group whereas SOD, CAT and GSH-Px contents were greatly higher than those of control group. Conclusion Exchange transfusion can improve the renal function and inhibit the inflammatory and oxidative stress response in children with hyperbilirubinemia.
- Hyperbilirubinemia,
- Exchange transfusion,
- Renal function,
- Inflammatory response,
- Oxidative stress response

FullText(HTML)

References(12)

References

[1]	[1]ISA H M, MOHAMED M S, MOHAMED A M, et al.Neonatal indirect hyperbilirubinemia and glucose-6-phosphate dehydrogenase deficiency[J].Korean J Pediatr, 2017, 60 (4) :106-111.
[2]	[2]AL-OMRAN A, AL-ABDI S, AL-SALAM Z.Readmission for neonatal hyperbilirubinemia in an area with a high prevalence of glucose-6-phosphate dehydrogenase deficiency:A hospital-based retrospective study[J].J Neonatal Perinatal Med, 2017, 10 (2) :181-189.
[3]	[3]STEBELOVA K, KOSNACOVA J, ZEMAN M.Intense blue light therapy during the night-time does not suppress the rhythmic melatonin biosynthesis in a young boy[J].Endocr Regul, 2017, 51 (1) :31-34.
[4]	[4]BHUTANI V K, MENG N F, KNAUER Y, et al.Extreme hyperbilirubinemia and rescue exchange transfusion in California from 2007 to 2012[J].J Perinatol, 2016, 36 (10) :853-857.
[5]	[5]VIDAL E, GARZOTTO F, PAROLIN M, et al.Therapeutic Plasma Exchange in Neonates and Infants:Successful Use of a Miniaturized Machine[J].Blood Purif, 2017, 44 (2) :100-105.
[6]	[6]ULLAH S, RAHMAN K, HEDAYATI M.Hyperbilirubinemia in neonates:types, causes, clinical examinations, preventive measures and treatments:A narrative review article[J].Iran J Public Health, 2016, 45 (5) :558-568.
[7]	[7]EBBESEN F, MADSEN P H, VANDBORG P K, et al.Bilirubin isomer distribution in jaundiced neonates during phototherapy with LED light centered at 497 nm (turquoise) vs.459 nm (blue) [J].Pediatr Res, 2016, 80 (4) :511-515.
[8]	[8]YU C, LI H, ZHANG Q, et al.Report about term infants with severe hyperbilirubinemia undergoing exchange transfusion in Southwestern China during an 11-year period, from 2001 to 2011[J].PLo S One, 2017, 12 (6) :e0179550.
[9]	[9]DURANTE P P, KREBS V L, BRUNOW DE CARVALHO W.Severe hyperbilirubinemia in exchange transfusion:less indication and lower mortality[J].Pediatr Crit Care Med, 2016, 17 (7) :705.
[10]	[10]DIAZ SO, PINTO J, BARROS A S, et al.Newborn urinary metabolic signatures of prematurity and other disorders:A case control study[J].J Proteome Res, 2016, 15 (1) :311-325.
[11]	[11]BALLOT D E, RUGAMBA G.Exchange transfusion for neonatal hyperbilirubinemia in johannesburg, south africa, from 2006 to 2011[J].Int Sch Res Notices, 2016, 29 (2016) :1268149.
[12]	[12]SUN XM, KANG P, TAO K.Causes of immune dysfunction in hyperbilirubinemia model rats[J].Asian Pac J Trop Med, 2015, 8 (5) :382-385.

Relative Articles(20)

Relative Articles

[1]	Weihua ZHANG, Shanshan QIN, Sicong WEN, Pingyu WU, Zhaoguang SONG. The Mechanism of Acetylcysteine Aerosol Inhalation Combined with Non-invasive Ventilator NIPSV Mode in the Treatment of AECOPD with Respiratory Failure by Regulating Immune Inflammatory Response. Journal of Kunming Medical University, 2024, 45(7): 113-118. doi: 10.12259/j.issn.2095-610X.S20240717
[2]	Ji WANG, Songtao BIN, Li TAN. Study on the Efficacy of Acetylcysteine in Severe Pneumonia in Children under Electronic Bronchoscopy. Journal of Kunming Medical University, 2024, 45(6): 113-119. doi: 10.12259/j.issn.2095-610X.S20240615
[3]	Man YANG, Xingan ZHAO, Yunna GE, Juan QIN, Xiya WANG, Siming TAO. Identification of Atrial Fibrillation-related Inflammatory Genes and Their Association with Immune Cell Infiltration Based on Comprehensive Bioinformatic Analysis. Journal of Kunming Medical University, 2024, 45(3): 18-29. doi: 10.12259/j.issn.2095-610X.S20240303
[4]	Yidan FU, Wenting CHEN, Xiaoyang SU, Yan ZHAO, Danfeng LAN, Qiuping YANG. Role of Mertk-mediated NF-κb Pathway in Inflammatory Response of Schwann Cells. Journal of Kunming Medical University, 2023, 44(12): 20-24. doi: 10.12259/j.issn.2095-610X.S20231203
[5]	Yan ZHANG, Haojie ZHAO, Mingzhi DUAN, Jingyan DUAN, Xueyan YANG. Interventional Effect and Mechanism of Saikosaponin A on Noise-induced Tinnitus in Mice. Journal of Kunming Medical University, 2023, 44(11): 29-37. doi: 10.12259/j.issn.2095-610X.S20231105
[6]	Yaling ZHAO, Kun WU, Kai WANG, Rong HUANG, Genya HE, Yuhui NA, Miao HE, Zhenbo DING, Caiying ZHANG. Influence of Intrauterine Hyperglycemia Environment on Peripheral Inflammatory Response in Offspring of Gestational Diabetes Mellitus. Journal of Kunming Medical University, 2023, 44(11): 70-75. doi: 10.12259/j.issn.2095-610X.S20231110
[7]	Wan DENG, Yu-e ZHOU, Tian-yun LIU, Yan-zheng YANG, Li LIN. Clinical Significance of Carboxyhemoglobin in Neonatal ABO Hemolytic Jaundice. Journal of Kunming Medical University, 2021, 42(5): 143-146. doi: 10.12259/j.issn.2095-610X.S20210526
[8]	Li-yuan AN, Bing LI, Gang SU. Effects of Different Doses of Ulinastatinon Postoperative Cognitive Function and HMGB1 in Elderly Patients. Journal of Kunming Medical University, 2021, 42(7): 121-125. doi: 10.12259/j.issn.2095-610X.S20210720
[9]	Jun-jie LI, Hai-yan JIANG, Wen-ya BAI, Si-ying HUO, Zhi-sheng SUN, Jian-lin SHAO. Effects of Silencing RND3 Expression on the Inflammatory Response and Apoptosis of Hippocampal Neurons Injured by Oxygen Glucose Deprivation/Reoxygenation. Journal of Kunming Medical University, 2021, 42(10): 14-21. doi: 10.12259/j.issn.2095-610X.S20211012
[10]	Xiao-zhi XU, Jing-hui YANG. Comparison of Exchange Transfusion and Intensive Phototherapy in the Treatment of Neonatal Hyperbilirubinemia. Journal of Kunming Medical University, 2020, 41(11): 44-48. doi: 10.12259/j.issn.2095-610X.S20201131
[11]	Jiang Yu Hui , Liu Ling , He Can Lin , Li Yang . . Journal of Kunming Medical University, 2019, 40(04): 20-22.
[12]	Wang Guang , Yang Tong Xin , Jiang Yong Ming , Fang Ke Wei , Liu Jian He , Li Jiong Ming . . Journal of Kunming Medical University, 2019, 40(06): 23-27.
[13]	Chen Zhong Yi , Qiao Ting Ting , Dong Bao Lian , Guo Ling . A Study of LPS Mediated Inflammatory Oxidation Reaction of Three Types of Rodents. Journal of Kunming Medical University, 2018, 39(06): 7-13.
[14]	Zhang Nan Yang , Pan Yu , Wu Guo Dong , Zeng Yue Qin , Chen Liang . . Journal of Kunming Medical University, 2018, 39(12): 23-27.
[15]	Wei Jiang Xia , Wang Mei , Liu Gui , Dai Xue Mei . A Study on the Effects of Cold Knife Excision by Hysteroscopy for the Local Microcirculation and Inflammatory Reaction of Patients with Hysteromyoma. Journal of Kunming Medical University, 2018, 39(05): 111-114.
[16]	Li Fei . Effect of Celebrex on the Hemorheology and Levels of Inflammatory Factors in Patients with Delayed Fracture Healing. Journal of Kunming Medical University,
[17]	Jia Peng Wei . . Journal of Kunming Medical University,
[18]	Chen Fei . . Journal of Kunming Medical University,
[19]	Zhang Yang . . Journal of Kunming Medical University,
[20]	Yan Qing Feng . Effects of Luteolin on Isolated Heart Function and Oxidative Stress Reaction after Hypothermic Preservation. Journal of Kunming Medical University,