The Progress of IL-10 and Autoimmune Diseases

Chen Mo; Zhou Ze Ping

Article Contents

Article Navigation > Journal of Kunming Medical University > 2018 > 39(02): 1-4

Chen Mo , Zhou Ze Ping . The Progress of IL-10 and Autoimmune Diseases[J]. Journal of Kunming Medical University, 2018, 39(02): 1-4.

Citation:

Chen Mo , Zhou Ze Ping . The Progress of IL-10 and Autoimmune Diseases[J]. Journal of Kunming Medical University, 2018, 39(02): 1-4.

Chen Mo , Zhou Ze Ping . The Progress of IL-10 and Autoimmune Diseases[J]. Journal of Kunming Medical University, 2018, 39(02): 1-4.

Citation:

Chen Mo , Zhou Ze Ping . The Progress of IL-10 and Autoimmune Diseases[J]. Journal of Kunming Medical University, 2018, 39(02): 1-4.

PDF( 731 KB)

The Progress of IL-10 and Autoimmune Diseases

Chen Mo ,
Zhou Ze Ping

Funds:

作者简介：陈墨 (1992~) , 男, 湖北黄石市人, 在读硕士研究生, 主要从事血液科临床工作.; 周泽平.E-mail:zhouzeping@outlook.com男, 43岁, 博士, 教授, 博士研究生导师.2007年毕业于中国协和医科大学.现为昆明医科大学第二附属医院血液科主任, 云南省中青年学术及技术带头人后备人才, 云南省高层次卫生技术人才学科带头人, 云南省省级临床重点专科负责人, 昆明医科大学创新团队负责人.中华医学会血液学分会止血与血栓学组委员、青年委员, 云南省血液学会副主任委员, 中国研究型医院学会生物治疗学专委会委员, 中国老年医学会血液学分会委员, 昆明医科大学第七届学术委员会委员等.主持国家自然科学基金3项, 省部级项目8项, 发表论文50篇, 其中SCI收录23篇.参编英文专著1部及中文专著5部.;

基金：国家自然科学基金资助项目 (81560029); 云南省中青年学术及技术带头人后备人才基金资助项目 (2013HB088);

Received Date: 2017-11-19

Abstract

Abstract

Interleukin-10 (IL-10) , a single strand glycoprotein, is produced by both adaptive and innate immune cells. IL-10 specific receptor as a complex consists of two submits IL-10 R1 and IL-10 R2. IL-10 mainly plays biological functions via JAK-STAT signaling pathway. IL-10 is a crucial anti-inflammation cytokine taking part in immune regulation and having significant effect on autoimmune diseases. This paper reviews the relationships between IL-10 and autoimmune diseases according to research achievements in recent years.
- Interleukin-10,
- Immune regulation,
- Autoimmune diseases

FullText(HTML)

References(23)

References

[1]	[1]RAMAKRISHNAN V, HUSAIN R A, AHMED S S.Genetic predisposition of IL-10 promoter polymorphisms with risk of multiple sclerosis:A meta-analysis[J].Journal of Neuroimmunology, 2017, 306 (3) :11-18.
[2]	[2]RAJASEKARAN A, SHIVAKUMAR V, KALMADY S V, et al.The impact of IL10 polymorphisms and s HLA-G levels on the risk of schizophrenia.[J].Asian Journal of Psychiatry, 2016, 23 (2) :39-43.
[3]	[3]PALMER V L, NGANGA V K, ROTHERMUND M E, et al.Cd1d regulates B cell development but not B cell accumulation and IL10 production in mice with pathologic CD5 (+) B cell expansion[J].Bmc Immunology, 2015, 16 (1) :66-67.
[4]	[4]BERTI F C B, PEREIRA A P L, TRUGILO K P, et al.IL-10, gene polymorphism c.-592C>A increases HPV infection susceptibility and influences IL-10 levels in HPV infected women[J].Infection Genetics&Evolution Journal of Molecular Epidemiology&Evolutionary Genetics in Infectious Diseases, 2017, 53 (14) :128-134.
[5]	[5]SHOUVAL D S, BISWAS A, KANG Y H, et al.Interleukin 1βMediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency[J].Gastroenterology, 2016, 151 (6) :1100-1101.
[6]	[6]KHARE V, PAUL G, MOVADAT O, et al.IL10R2 Overexpression Promotes IL22/STAT3 Signaling in Colorectal Carcinogenesis[J].Cancer Immunology Research, 2015, 3 (11) :2326-6066.
[7]	[7]KAPELSKI P, SKIBINSKA M, MACIUKIEWICZ M, et al.Family-based association study of interleukin 10 (IL10) and interleukin 10 receptor alpha (IL10RA) functional polymorphisms in schizophrenia in Polish population[J].Journal of Neuroimmunology, 2016, 297 (11) :92-97.
[8]	[8]DENNIS K L, SAADALLA A, BLATNER N R, et al.T-cell expression of IL10 is essential for tumor immune surveillance in the small intestine[J].Cancer Immunology Research, 2015, 3 (7) :806-807.
[9]	[9]OSADA Y, FUJIYAMA T, KAMIMURA N, et al.Dual genetic absence of STAT6 and IL-10 does not abrogate anti-hyperglycemic effects of Schistosoma mansoni in streptozotocin-treated diabetic mice.[J].Experimental Parasitology, 2017, 177 (5) :1-12.
[10]	[10]LIU X, ZHANG S, LI X, et al.Vaccination with a co-expression DNA plasmid containing GAD65 fragment gene and IL-10 gene induces regulatory CD4 (+) T cells that prevent experimental autoimmune diabetes[J].Diabetes/metabolism Research&Reviews, 2016, 32 (6) :522-533.
[11]	[11]LI Y Y, PEARSON J A, CHEN C, et al.Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) modulates T1DM susceptibility by gut microbiota[J].Journal of Autoimmunity, 2017, 54 (8) :10-14.
[12]	[12]HEINEMANN K, WILDE B, HOERNING A, et al.Decreased IL-10 (+) regulatory B cells (Bregs) in lupus nephritis patients[J].Scandinavian Journal of Rheumatology, 2016, 33 (4) :1-2.
[13]	[13]YANG X, SUN B, WANG H, et al.Increased serum IL-10in lupus patients promotes apoptosis of T cell subsets via the caspase 8 pathway initiated by Fas signaling[J].Journal of Biomedical Research, 2015, 29 (3) :232-240.
[14]	[14]VADASZ Z, PERI R, EIZA N, et al.The Expansion of CD25high IL-10high Fox P3high B Regulatory Cells Is in Association with SLE Disease Activity[J].Journal of immunology Research, 2015, 2015 (4) :1-6.
[15]	[15]LI X, ZHONG H, BAO W, et al.Defective regulatory B-cell compartment in patients with immune thrombocytopenia[J].Blood, 2012, 120 (16) :3318-3325.
[16]	[16]MOKHTAR G M, ELBEBLAWY N M, Adly A A, et al.Cytokine gene polymorphism[tumor necrosis factor-alpha (-308) , IL-10 (-1082) , IL-6 (-174) , IL-17F, 1Ra VNTR]in pediatric patients with primary immune thrombocytopenia and response to different treatment modalities.[J].Blood Coagul Fibrinolysis, 2016, 27 (2) :34-38.
[17]	[17]HUA F, YING L, XIN Z, et al.The expression profile of toll-like receptor signaling molecules in CD19+, B cells from patients with primary immune thrombocytopenia[J].Immunology Letters, 2016, 176 (11) :28-35.
[18]	[18]TAWFIK T Z, GAD A H, MEHANEY D A, et al.Interleukins 17 and 10 in a sample of Egyptian relapsing remitting multiple sclerosis patients[J].Journal of the Neurological Sciences, 2016, 369 (22) :36-38.
[19]	[19]RONG Z, ZENG H, YUN Z, et al.CD226 ligation protects against EAE by promoting IL-10 expression via regulation of CD4+T cell differentiation[J].Oncotarget, 2016, 7 (15) :19251-19264.
[20]	[20]RAMAKRISHNAN V, HUSAIN R A, AHMED S S.Genetic predisposition of IL-10 promoter polymorphisms with risk of multiple sclerosis:A meta-analysis[J].Journal of Neuroimmunology, 2017, 306 (12) :11-18.
[21]	[21]ISHIGURO K, WATANABE O, NAKAMURA M, et al.S100G expression and function in fibroblasts on colitis induction[J].International Immunopharmacology, 2016, 39 (6) :92-96.
[22]	[22]ZHOU L, CHENG L, HE Y, et al.Association of gene polymorphisms of FV, FII, MTHFR, SERPINE1, CTLA4, IL10, and TNFalpha with pre-eclampsia in Chinese women[J].Inflammation Research, 2016, 65 (9) :1-8.
[23]	[23]GUO P, LI G, SUN X, et al.Influence of IL10 Gene polymorphisms on the sustained virologic response of patients with chronic hepatitis C to PEG-interferon/ribavirin therapy[J].Infection Genetics&Evolution Journal of Molecular Epidemiology&Evolutionary Genetics in Infectious Diseases, 2016, 45 (6) :48-55.

Relative Articles(20)

Relative Articles

[1]	Shulan SHI, Lijuan QIU, Liyue KUI, Min SU, Bailing ZHOU, Rongjie LI, Jianming SUN. Diagnostic Value of Interleukin-6，Interleukin-10，High-sensitivity C-reactive Protein and Procalcitonin in Children with Acute Lymphoblastic Leukemia Complicated by Infection. Journal of Kunming Medical University, 2023, 44(1): 104-108. doi: 10.12259/j.issn.2095-610X.S20230115
[2]	Ranxi SHI, Tao YANG, Qing CHENG, Liangchen ZHAO, Jiahui GUO, Limei WANG. Mechanism of Dendrobium Officinale Against Inflammatory Aging Based on Network Pharmacology and Molecular Docking. Journal of Kunming Medical University, 2023, 44(11): 1-8. doi: 10.12259/j.issn.2095-610X.S20231101
[3]	Guozhu LIANG, Shimei RUAN, Yanmei HE, Hailong YANG. Prospects of Antimicrobial Peptides as Immunomodulators in the Treatment of Bacterial Infections. Journal of Kunming Medical University, 2023, 44(10): 189-195. doi: 10.12259/j.issn.2095-610X.S20231013
[4]	Weiwei DAI, Weiwei FENG, Defu LI, Shan LIN, Wei QIN. Analysis of Depression and Suicide Risk in Hospitalized Patients with Rheumatic Immune Diseases. Journal of Kunming Medical University, 2022, 43(3): 160-165. doi: 10.12259/j.issn.2095-610X.S20220302
[5]	Yang YANG, Xue-song YANG, Jian-zhou YE, Hong-ying LI, Si-xuan CHEN. Progress on Regulating Immune Barrier of Atopic Dermatitis by Jianpi Yangxue Qufeng Decoction. Journal of Kunming Medical University, 2021, 42(2): 140-146. doi: 10.12259/j.issn.2095-610X.S20210220
[6]	Quan Yu Hang , Wang Zhong Hui , Wang Ya Hong . . Journal of Kunming Medical University, 2020, 41(04): 74-78.
[7]	Mang Yuan 祎, Li Li , Ran Jiang Hua , Sheng Ning , Liu Jing , Liu Jian , Gao Yang , Li Lai Bang . . Journal of Kunming Medical University, 2019, 40(01): 14-19.
[8]	Cheng Min , Shi Kai De , Liu Xing . . Journal of Kunming Medical University, 2017, 38(02): 86-89.
[9]	Xu Rong . The Value of Detecting Paratracheal Lymph Nodes by Ultrasonography in Diagnosis of Autoimmune Thyroiditis. Journal of Kunming Medical University,
[10]	Li Ying . . Journal of Kunming Medical University,
[11]	Yao Na . . Journal of Kunming Medical University,
[12]	Li Xiao Yong . . Journal of Kunming Medical University,
[13]	Zhao Min . . Journal of Kunming Medical University,
[14]	Zhou Yi Zhong . . Journal of Kunming Medical University,
[15]	Wang Feng . . Journal of Kunming Medical University,
[16]	Wu Hua Mei . . Journal of Kunming Medical University,
[17]	. Clinical and Pathological Characteristics of 92 Patients with Autoimmune Hepatitis. Journal of Kunming Medical University,
[18]	. The Dynamic Changes of TNF-α, β-EP and IL-10 in the Plasma of Rats after Severe Trauma. Journal of Kunming Medical University,
[19]	. . Journal of Kunming Medical University,
[20]	Zhang Cai Jun . . Journal of Kunming Medical University,