The Research of Effects of Applying Cataplasm of Paris Polyphylla Smith Var. Yunnanensis (Franch.) Hand.-Mazz on Acute Gouty Arthritis and Inflammation

Dong Wei; Yuan Xiao Lin; Li Jiao; Li Zheng Yan; Liu Wei Tong; Yu Xiao Ling; Zhang Ying

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Article Navigation > Journal of Kunming Medical University > 2018 > 39(02): 21-24

Dong Wei , Yuan Xiao Lin , Li Jiao , Li Zheng Yan , Liu Wei Tong , Yu Xiao Ling , Zhang Ying . The Research of Effects of Applying Cataplasm of Paris Polyphylla Smith Var. Yunnanensis (Franch.) Hand.-Mazz on Acute Gouty Arthritis and Inflammation[J]. Journal of Kunming Medical University, 2018, 39(02): 21-24.

Citation:

Dong Wei , Yuan Xiao Lin , Li Jiao , Li Zheng Yan , Liu Wei Tong , Yu Xiao Ling , Zhang Ying . The Research of Effects of Applying Cataplasm of Paris Polyphylla Smith Var. Yunnanensis (Franch.) Hand.-Mazz on Acute Gouty Arthritis and Inflammation[J]. Journal of Kunming Medical University, 2018, 39(02): 21-24.

Citation:

Dong Wei , Yuan Xiao Lin , Li Jiao , Li Zheng Yan , Liu Wei Tong , Yu Xiao Ling , Zhang Ying . The Research of Effects of Applying Cataplasm of Paris Polyphylla Smith Var. Yunnanensis (Franch.) Hand.-Mazz on Acute Gouty Arthritis and Inflammation[J]. Journal of Kunming Medical University, 2018, 39(02): 21-24.

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The Research of Effects of Applying Cataplasm of Paris Polyphylla Smith Var. Yunnanensis (Franch.) Hand.-Mazz on Acute Gouty Arthritis and Inflammation

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基金：昆明市科技计划基金资助项目 (2015-1-S-00667); 云南省医疗卫生单位内设研究机构科研项目 (2016NS301);

Received Date: 2017-10-24

Abstract

Abstract

Objective This study is designed to improve topical medication in the Department of Orthopedics in Kunming Municipal Hospital of Traditional Chinese Medicine by applying cataplasm made from the active ingredient (polyphyllin) of Paris polyphylla Smith var. yunnanensis (Franch.) Hand.-Mazz ( "Dian Chonglou" in Chinese) and to study the mechanism of anti-inflammation. Me thods SD male rats were randomly divided into two groups: control group and treatment group. The rats in two groups were all injected 50 ul 5% sodium urate suspension into tibiotarsal joint cavity to duplicate the model of acute gouty arthritis.The rats in the control group were applied with cataplasm without polyphyllin, whereas those in the treatment group applied with cataplasm of polyphyllin. After 4, 24, 48, 72 hours, the ankle diameter and circumference were measured. ELISA was used to test the interleukin-1β (IL-1β) andtumor necrosis factor (TNF) in peripheral blood. Western blotting was applied to detect the changes in TLR4 expression of monocyte.Re s ults Compared with the control group, the added value of the diameter and circumference of ankle decreased significantly in the treatment group 4, 24, 48 and 72 h after the treatment.IL-1β in the treatment group was lowered at 4, 24 and 72 h. TLR4 in the treatment group decreased at 48 h. Conclus ion Cataplasm with polyphyllin can alleviate the acute inflammatory reaction in gouty joint of rat by reducing the expression of IL-1βand TLR4.
- Cataplasm of Paris polyphylla Smith var,
- yunnanensis (Franch.) Hand,
- -Mazz,
- Gouty arthritis,
- Pro-inflammatory cytokines,
- Therapeutic evaluation

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References(12)

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