A Study of Correlation between NDST3 Gene Polymorphism and Schizophrenia Among Han People in Yunnan

Jiang Hong Yan; Ran Liu Yi; Wu Gui Xia; Xu Xiu Feng; Yu Li

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Jiang Hong Yan , Ran Liu Yi , Wu Gui Xia , Xu Xiu Feng , Yu Li . A Study of Correlation between NDST3 Gene Polymorphism and Schizophrenia Among Han People in Yunnan[J]. Journal of Kunming Medical University, 2018, 39(02): 51-54.

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Jiang Hong Yan , Ran Liu Yi , Wu Gui Xia , Xu Xiu Feng , Yu Li . A Study of Correlation between NDST3 Gene Polymorphism and Schizophrenia Among Han People in Yunnan[J]. Journal of Kunming Medical University, 2018, 39(02): 51-54.

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A Study of Correlation between NDST3 Gene Polymorphism and Schizophrenia Among Han People in Yunnan

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基金：云南省教育厅科学研究基金资助项目 (2014C029Y);

Received Date: 2017-10-17

Abstract

Abstract

Objective To investigate the association between rs11098403 of the NDST3 gene and schizophrenia among Han People in Yunnan. Me thods A total of 364 Han patients with schizophrenia and 287 healthy Han people were enrolled in our study. SNa P shot was used to detect the genotype of rs11098403. Positive and Negative Symptoms scale (PANSS) was used to assess the symptoms of schizophrenia.Re s ults No differences were found in the genotype and allele distributions of rs11098403 among patients and the control group (P>0.05) .The allelic frequencies of rs11098403 showed no significant association with positive symptoms, negative symptoms or general symptoms (P>0.05) . Conclus ions Our study indicated that the association between NDST3 gene and schizophrenia might be specific to European population.
- Schizophrenia,
- NDST3,
- Polymorphism,
- rs11098403,
- Han Chinese,
- Positive and Negative Symptoms Scale

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References(12)

References

[1]	[1]SINGH S, KUMAR A, AGARWAL S, et al. (2014) Genetic insight of schizophrenia:past and future perspectives[J].Gene, 2014, 535 (2) :97-100.
[2]侯羲, 张玉清, 王彩萍, 等.精神分裂症患者入院时生命质量相关因素[J].昆明医科大学学报, 2015, 36 (1) :149-150.
[3]	[3]O'DONOVAN M C, CRADDOCK N J, OWEN M J.Genetics of psychosis;insights from views across the genome[J].Hum Genet, 2009, 126 (1) :3-12.
[4]	[4] HAMSHERE ML, WALTERS J T, SMITH R, et al. (2013) Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC[J].Mol Psychiatry, 2013, 18 (7) :708-712.
[5]	[5] RIPKE S, ODUSHLAINE C, CHAMBERT K, et al.Genome wide association analysis identifies 13 new risk loci for schizophrenia[J].Nat Genet, 2013, 45 (10) :1150-1159.
[6]	[6] WALTON E, GEISLER D, HASS J, et al.The impact of genome-wide supported schizophrenia risk variants in the neurogranin gene on brain structure and function[J].PLo S One, 2013, 8 (10) :e76815-e76826.
[7]	[7] LEIN E S, HAWRYLYCZ M J, AO N, et al.Genome-wide atlas of gene expression in the adult mouse brain[J].Nature, 2007, 445 (7124) :168-176.
[8]	[8] LENCZ T, GUHA S, LIU C, et al.Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder[J].Nat Commun, 2013, 11 (4) :2739.
[9]	[9] YUE W H, YU X, ZHANG D.Progress in genome-wide association studies of schizophrenia in Han Chinese populations[J].npj Schizophrenia, 2017, 24 (3) :1-11.
[10]	[10]GU L Z, JIANG T, CHENG Z H, et al.rs11098403 polymorphism near NDST3 is associated with a reduced risk of schizophrenia in a Han Chinese population[J].Neurosci Lett, 2014, 581 (10) :42-45.
[11]	[11] ZHANG C, LU W, WANG Z, et al. (2016) A comprehensive analysis of NDST3 for schizophrenia and bipolar disorder in Han Chinese[J].Transl Psychiatry, 2016, 1 (6) :e701-e706.
[12]冯国华, 卫芋君, 元静, 等.DRD2和DRD3基因多态性与利培酮治疗精神分裂症疗效的关联性[J].昆明医科大学学报, 2017, 38 (5) :50-55.

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