Research Progress of Gas6 with Type 2Diabetes Mellitus and Diabetic Complications

Dong Xue E; Li Hui Fang

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Dong Xue E , Li Hui Fang . Research Progress of Gas6 with Type 2Diabetes Mellitus and Diabetic Complications[J]. Journal of Kunming Medical University, 2018, 39(03): 119-124.

Citation:

Dong Xue E , Li Hui Fang . Research Progress of Gas6 with Type 2Diabetes Mellitus and Diabetic Complications[J]. Journal of Kunming Medical University, 2018, 39(03): 119-124.

Dong Xue E , Li Hui Fang . Research Progress of Gas6 with Type 2Diabetes Mellitus and Diabetic Complications[J]. Journal of Kunming Medical University, 2018, 39(03): 119-124.

Citation:

Dong Xue E , Li Hui Fang . Research Progress of Gas6 with Type 2Diabetes Mellitus and Diabetic Complications[J]. Journal of Kunming Medical University, 2018, 39(03): 119-124.

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Research Progress of Gas6 with Type 2Diabetes Mellitus and Diabetic Complications

Dong Xue E ,
Li Hui Fang

Funds:

基金：国家自然科学基金资助项目 (81160104, 30760087); 云南省卫生科技计划项目 (2017NS049);

Received Date: 2017-08-19

Abstract

Abstract

Growth arrest-specific 6, which is a member of the vitamin K-dependent protein family, is a ligand of TAM (Tyro3, Axl, Mer) belonging to the receptor tyrosine kinase family.Gas6/Axl signaling pathways are involved in pathophysiological processes of cell adhesion, migration, proliferation, apoptosis, platelet aggregation, vascular remodeling, inflammatory and immune responses. In recent years, studies found that Gas6/Axl signaling pathway, Gas6 level and the gene polymorphism of Gas6 were significantly associated with type 2 diabetes, obesity, insulin resistance and diabetic complications.This article reviews the correlation between Gas6 and type 2 diabetes and its complications
- Growth arrest-specific 6,
- Type 2 diabetes mellitus,
- Obesity,
- Insulin resistance,
- Diabetic complications

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References(49)

References

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