Research on Preparation and in Vitro Release of pH Sensitive Gel for Eye Cornea of Salvianolic Acid B

Ke Jin; Zhao Zi Wei; Li Shan Shan; Zhu Pei Fang; Hou An Guo

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Article Navigation > Journal of Kunming Medical University > 2018 > 39(03): 23-30

Ke Jin , Zhao Zi Wei , Li Shan Shan , Zhu Pei Fang , Hou An Guo . Research on Preparation and in Vitro Release of pH Sensitive Gel for Eye Cornea of Salvianolic Acid B[J]. Journal of Kunming Medical University, 2018, 39(03): 23-30.

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Ke Jin , Zhao Zi Wei , Li Shan Shan , Zhu Pei Fang , Hou An Guo . Research on Preparation and in Vitro Release of pH Sensitive Gel for Eye Cornea of Salvianolic Acid B[J]. Journal of Kunming Medical University, 2018, 39(03): 23-30.

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Research on Preparation and in Vitro Release of pH Sensitive Gel for Eye Cornea of Salvianolic Acid B

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基金：云南省科技厅应用基础研究基金资助项目 (2014FZ089); 云南省科技厅-云南中医学院应用基础研究联合专项基金资助项目 (2015FB205-003); 云南省重点实验培育计划 (2017DG006);

Received Date: 2017-09-14

Abstract

Abstract

Objective To prepare pH sensitive gel for eye cornea of salvianolic acid B and accomplish in vitro release study. Me thods We used corneal permeability, eye irritation in rabbits, hydration of the cornea, viscosity, gel capacity, transparency, liquidity as index, to select pH sensitive gel matrix composition. Re s ults The gel composition was: 0.5% of salvianolic acid B, 0.14% Carbomer, 0.3% HPMC, 0.05% Azone, 0.1% ethylparaben and 0.2% Vc. The corneal hydration level was 77.32±1.88.The gel released 27.21% drug in 15 min, and released 97.44% drug in 6 h. By research of corneal permeability, the cumulative release of gel was bigger than the one of saline (P<0.05) . Conclus ions The selection of the gel matrix prescription is reasonable in design, simple in process, not harsh to eyes, and can prolong the retention time of drug in corneas and improve the corneal penetration.
- Alvianolic acid B,
- pH sensitive gel for eye cornea,
- Corneal permeability,
- In-vitro release

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References(19)

References

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