Relationship between the Proportion of Tumor Infiltrating Lymphocytes in Tumor Mass and Postoperative Recurrence of Prostate Carcinoma

Ran Zhen; Zhu Yun Sha; Hai Bing; Zhang Jing Song

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Ran Zhen , Zhu Yun Sha , Hai Bing , Zhang Jing Song . Relationship between the Proportion of Tumor Infiltrating Lymphocytes in Tumor Mass and Postoperative Recurrence of Prostate Carcinoma[J]. Journal of Kunming Medical University, 2018, 39(03): 62-66.

Citation:

Ran Zhen , Zhu Yun Sha , Hai Bing , Zhang Jing Song . Relationship between the Proportion of Tumor Infiltrating Lymphocytes in Tumor Mass and Postoperative Recurrence of Prostate Carcinoma[J]. Journal of Kunming Medical University, 2018, 39(03): 62-66.

Citation:

Ran Zhen , Zhu Yun Sha , Hai Bing , Zhang Jing Song . Relationship between the Proportion of Tumor Infiltrating Lymphocytes in Tumor Mass and Postoperative Recurrence of Prostate Carcinoma[J]. Journal of Kunming Medical University, 2018, 39(03): 62-66.

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Relationship between the Proportion of Tumor Infiltrating Lymphocytes in Tumor Mass and Postoperative Recurrence of Prostate Carcinoma

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2017FE468);

Received Date: 2017-11-19

Abstract

Abstract

Objective To investigate the relationship between proportion of Tumor infiltrating lymphocytes (TILs) in the prostate tumor mass and postoperative recurrence of prostate carcinoma in order to offer the theoretic as well as experimental basis for the prevention of postoperative recurrence in the prostate carcinoma.Methods The proportion of CD3+, CD8+, CD3+CD4+, CD3+CD8+ TILs cells of 81 PCa specimens underwent Radical prostatectomy were analyzed. The proportion of CD3+CD8+TILs in patients with recurrence of PCa within3 years after surgery (group A), within 35 years (group B) and without recurrence after 5 years (group C) was compared. Results The proportion of CD3+CD8+TILs was significantly lower in group A than that of in group B and C (P<0.05), meanwhile, the proportion of CD3+CD8+TILs were significantly higher in group C than that in group A and B (P<0.05), while="" the="" proportion="" of="" in="" three="" groups="" had="" no="" significant="" difference="" p="">0.05). Conclusion The proportion of CD3+CD8+TILs presented in the PCa specimen mass is relative to the postoperative recurrence of prostate cancer, which might be a biomarker for the surveillance of postoperative recurrence of PCa.
- Prostate cancer,
- Recurrence,
- Tumor infiltrating lymphocytes

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References(18)

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