Clinical Study of Glucosidorum Tripterygll Totorum Combined with Prednisone Acetate and Hydroxychloroquine Sulfate in Treatment of Systemic Lupus Erythematosus

Chen Yi

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Chen Yi . Clinical Study of Glucosidorum Tripterygll Totorum Combined with Prednisone Acetate and Hydroxychloroquine Sulfate in Treatment of Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2018, 39(03): 98-102.

Citation:

Chen Yi . Clinical Study of Glucosidorum Tripterygll Totorum Combined with Prednisone Acetate and Hydroxychloroquine Sulfate in Treatment of Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2018, 39(03): 98-102.

Citation:

Chen Yi . Clinical Study of Glucosidorum Tripterygll Totorum Combined with Prednisone Acetate and Hydroxychloroquine Sulfate in Treatment of Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2018, 39(03): 98-102.

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Clinical Study of Glucosidorum Tripterygll Totorum Combined with Prednisone Acetate and Hydroxychloroquine Sulfate in Treatment of Systemic Lupus Erythematosus

Chen Yi

Funds:

基金：四川省卫生和计划生育委员会科研课题 (17PJ180);

Received Date: 2017-12-05

Abstract

Abstract

Objective To investigate the effect of glucosidorum tripterygll totorum combined with prednisone acetate and hydroxychloroquine sulfate in the treatment of systemic lupus erythematosus (SLE) . Me thods Eighty-two patients with SLE were divided into the control group (n=41) and the observation group (n=41) by the random number table method. The control group was treated with prednisone acetate combined with hydroxychloroquine sulfate. On the basis of treatment for the control group, the observation group was treated with glucosidorum tripterygll totorum. Four weeks was taken as 1 course of treatment and they were given 3 courses of treatment. Curative effect and adverse drug reactions were evaluated. The SLE disease activity index score was to evaluate the degree of lupus before and after treatment. The levels of blood lipid indexes [triglycerides (TG) , total cholesterol ( TC) , high density lipoprotein cholesterol ( HDL-C) , low density lipoprotein cholesterol (LDL-C) ], complement C3, immunoglobulin G (Ig G) , anti-double stranded DNA (ds-DNA) , interleukin 8 (IL-8) and interleukin 10 (IL-10) were determined. Re s ults The effective rate of the observation group was higher than that of the control group (92.50% vs 73.17% ) , P < 0.05. After treatment, the SLE-DAI score, levels of TC, TG, LDL-C, Ig G, anti-ds-DNA, IL-10 and IL-8 in the observation group were lower than those in the control group while levels of HDL-C and complement C3 were higher than those in the control group (all P < 0.05) . There was no significant difference in the incidence of adverse drug reactions between the two groups (56.10% vs 43.90% ) , P > 0.05. Conclusion The application of glucosidorum tripterygll totorum combined with prednisone acetate and hydroxychloroquine sulfate in the treatment of SLE can reduce the inflammatory and blood lipid levels and regulate immune mechanism. The effect is exact and patients can tolerate.
- Systemic lupus erythematosus,
- Prednisone acetate,
- Hydroxychloroquine sulfate,
- Glucosidorum tripterygll totorum,
- Blood lipid,
- Inflammatory factor,
- Curative effect

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References(18)

References

[1]左大辰, 宋良月, 张榕, 等.系统性红斑狼疮患者中恶性肿瘤发病风险的Meta分析[J].医学临床研究, 2014, 31 (10) :1914-1917.
[2]冯莉, 赵令, 马宁, 等.系统性红斑狼疮患者糖皮质激素联合免疫抑制剂治疗前后外周血NK细胞和受体表达变化及其治疗作用机制[J].吉林大学学报 (医学版) , 2014, 40 (1) :159-163.
[3]陈娟, 邓军, 周佳, 等.青蒿-鳖甲药对配伍治疗系统性红斑狼疮小鼠的代谢组学研究[J].中国药理学通报, 2016, 32 (5) :727-732.
[4]王韦.泼尼松联合雷公藤多苷治疗成人紫癜性肾炎的临床观察[J].现代药物与临床, 2013, 28 (6) :948-950.
[5]	[5]HOCHBERG M C.Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus[J].Arthritis Rheum, 1997, 40 (9) :1725.
[6]中华医学会风湿病学分会.系统性红斑狼疮诊治指南 (2003年) [J].现代实用医学, 2003, 15 (12) :764-769.
[7]程玉萍, 李丽.检测抗核抗体谱在系统性红斑狼疮诊治中的意义[J].解放军医药杂志, 2013, 25 (1) :63-66.
[8]罗泉芳.系统性红斑狼疮患者自身抗体、免疫球蛋白及补体的变化及临床意义[J].医学临床研究, 2013, 30 (2) :269-271.
[9]刘潇潇, 练颖.补肾活血法干预系统性红斑狼疮患者使用免疫抑制剂引起卵巢早衰的临床研究[J].四川中医, 2016, 34 (6) :102-104.
[10]陈明, 巩路.系统性红斑狼疮外周血Th1、Th2类细胞因子与血液系统损害的关系[J].山东医药, 2013, 53 (48) :70-71.
[11]饶慧, 肖嫦娟, 曾清华, 等.来氟米特联合糖皮质激素治疗系统性红斑狼疮的临床疗效及对血清IL-8和IL-10水平的影响[J].中国老年学杂志, 2015, 35 (23) :6874-6876.
[12]闫永龙, 宁晓然, 于织波等.抗双链DNA抗体与系统性红斑狼疮肝损伤的关系[J].中国全科医学, 2012, 15 (18) :2116-2117.
[13]胡丹, 刘洋, 刘燕玲, 等.系统性红斑狼疮患儿肿瘤坏死因子-α、抗ds-DNA抗体水平变化[J].临床儿科杂志, 2013, 21 (9) :830-832.
[14]李晓洁, 周蕾, 陈宪, 等.超敏C反应蛋白和补体C3与系统性红斑狼疮疾病活动度的关系[J].天津医科大学学报, 2015, 21 (1) :63-64, 71.
[15]黄莉, 顾美华, 王鸣军, 等.系统性红斑狼疮血脂结果分析和临床意义[J].中国血液流变学杂志, 2010, 20 (1) :102-104.
[16]苏江, 朱静, 董巍, 等.初诊系统性红斑狼疮患者血清25羟维生素D与炎性细胞因子的相关性[J].细胞与分子免疫学杂志, 2016, 32 (12) :1671-1674.
[17]刘谓, 阎磊, 朱清, 等.雷公藤多苷联合醋酸泼尼松治疗中度活动型系统性红斑狼疮的疗效观察[J].中华实用诊断与治疗杂志, 2014, 28 (12) :1234-1235, 1238.
[18]郭雪红.雷公藤多苷的药理作用及临床应用概述[J].中成药, 2010, 32 (7) :1199-1202.

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