幽门螺杆菌清除治疗中甲硝唑、克拉霉素、阿莫西林的耐药性

Cheng Si Gen; Luo Zhi Gang; Liu De Hua; Yang Shu

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Article Navigation > Journal of Kunming Medical University > 2018 > 39(04): 104-108

Cheng Si Gen , Luo Zhi Gang , Liu De Hua , Yang Shu . 幽门螺杆菌清除治疗中甲硝唑、克拉霉素、阿莫西林的耐药性[J]. Journal of Kunming Medical University, 2018, 39(04): 104-108.

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Cheng Si Gen , Luo Zhi Gang , Liu De Hua , Yang Shu . 幽门螺杆菌清除治疗中甲硝唑、克拉霉素、阿莫西林的耐药性[J]. Journal of Kunming Medical University, 2018, 39(04): 104-108.

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幽门螺杆菌清除治疗中甲硝唑、克拉霉素、阿莫西林的耐药性

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基金：云南省科技厅-昆明医科大学应用基础研究基金资助项目 (2014FB088);

Received Date: 2017-11-19

Abstract

Abstract

目的探究幽门螺杆菌 (H.pylori) 对不同种抗菌药物耐药问题的研究.方法选取云南省昆明市第一人民医院2015年8月至2017年4月接诊出现消化道症状且经胃镜检查确诊幽门螺杆菌感染的240例患者为研究对象, 按照临床给药不同分为A、B、C 3组, A组80例患者给予 (埃索美拉唑+甲硝唑+左氧氟沙星) 治疗, B组80例患者给予 (埃索美拉唑+克拉霉素+左氧氟沙星) 治疗, C组80例患者给予 (埃索美拉唑+阿莫西林+左氧氟沙星) 治疗, 3组患者治疗10 d后通过胃镜从患者胃窦取2块胃粘膜组织, 进行幽门螺杆菌培养及E-test测试, 观察幽门螺杆菌感染个体对不同种抗菌药物的耐药性、临床治疗效果以及不良反应发生情况.结果 A组甲硝唑耐药率为51.25% (54/80) , 明显高于B组、C组, C组临床治疗总有效率为93.50%, 明显高于B组与A组, C组不良反应发生率为3.75%, 明显低于B组、A组, 各项数据差异有统计学意义 (P<0.05) .结论清除幽门螺杆菌治疗中, 甲硝唑耐药性较高, 阿莫西林耐药性最低.
- Helicobacter pylori,
- Drug resistance,
- Sensitivity,
- Metronidazole,
- Clarithromycin,
- Antibacterial drug

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References(20)

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