An Analysis of the Outcome of 208 Cases of Intrahepatic Cholestasis in Pregnancy

Ma Cui; Yang Guang Qiong; Ma Run Mei; Jin Jia Ping; Cao Hua

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Article Navigation > Journal of Kunming Medical University > 2018 > 39(04): 117-120

Ma Cui , Yang Guang Qiong , Ma Run Mei , Jin Jia Ping , Cao Hua . An Analysis of the Outcome of 208 Cases of Intrahepatic Cholestasis in Pregnancy[J]. Journal of Kunming Medical University, 2018, 39(04): 117-120.

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Ma Cui , Yang Guang Qiong , Ma Run Mei , Jin Jia Ping , Cao Hua . An Analysis of the Outcome of 208 Cases of Intrahepatic Cholestasis in Pregnancy[J]. Journal of Kunming Medical University, 2018, 39(04): 117-120.

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An Analysis of the Outcome of 208 Cases of Intrahepatic Cholestasis in Pregnancy

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2015FA003);

Received Date: 2017-10-13

Abstract

Abstract

Objective To investigate the effects of amniotic fluid meconium contamination and timely termination of pregnancy on perinatal outcome of intrahepatic cholestasis of pregnancy (ICP) . Me thods From December 2012 to December 2015, 208 cases of ICP were selected in the Department of Obstetrics of the First People's Hospital of Zhaotong City, Yunnan Province. The retrospective study included two groups: the experimental group with 208 cases (ICP group) and the control group with10890 normal deliveries (non-ICP group) . They were treated as follows: (1) fetal monitoring; (2) tests of liver function, bile acid and coagulation; (3) selective amniocentesis or artificial membrane ruptured amniotic fluid traits; (4) determination of the timing of the termination; (5) the choice of gestation mode and the control of the amniotic fluid meconium contamination rate, premature birth rate and perinatal mortality. Re s ults Sixty-three cases (30.29%) of amniotic fluid meconium were found in ICP group including 5 cases of amniocentesis, 45 cases of artificial rupture of membranes, 10 cases of cesarean section and 3 cases of natural rupture. Preterm birth was 50 cases (24.04%) and cesarean section was120 cases (57.69%) . In the control group, there were 814 cases of amniotic fluid meconium (7.41%) , 1214 cases of preterm birth (11.15%) and 3424 cases (31.44%) of cesarean section. The rates of amniotic fluid infection, preterm birth and cesarean section in ICP patients were significantly higher than those in the control group (P <0.05) . Conclusion Important clinical value is observed in early detection of amniotic fluid meconium contamination and timely termination of pregnancy to reduce perinatal mortality among ICP patients.
- Amniotic fluid meconium contamination,
- Intrahepatic cholestasis,
- Perinatal outcome

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References(13)

References

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