The Progress in the Clinical Research of Lynch Syndrome

Zhou Yong Ming; Li Wen Liang

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Zhou Yong Ming , Li Wen Liang . The Progress in the Clinical Research of Lynch Syndrome[J]. Journal of Kunming Medical University, 2018, 39(04): 135-140.

Citation:

Zhou Yong Ming , Li Wen Liang . The Progress in the Clinical Research of Lynch Syndrome[J]. Journal of Kunming Medical University, 2018, 39(04): 135-140.

Zhou Yong Ming , Li Wen Liang . The Progress in the Clinical Research of Lynch Syndrome[J]. Journal of Kunming Medical University, 2018, 39(04): 135-140.

Citation:

Zhou Yong Ming , Li Wen Liang . The Progress in the Clinical Research of Lynch Syndrome[J]. Journal of Kunming Medical University, 2018, 39(04): 135-140.

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The Progress in the Clinical Research of Lynch Syndrome

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基金：国家自然科学基金资助项目 (31660312);

Received Date: 2017-11-19

Abstract

Abstract

Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, an autosomal dominant inherited disease which is caused by mismatch repair system defect. Learning knowledge in the genetics and diagnosis of LS, and identifying at-risk patients and making a correct diagnosis are the keys to successful screening and surgical decision-making and chemoprevention which is important to decrease formation of and death from cancers. This article reviews recent developments in mainly the clinical features, genetics, current diagnostic standard and diagnosis, surveillance, management, treatment and other related syndromes of LS.
- Colorectal cancer,
- Lynch syndrome,
- Mismatch repair gene,
- Immunohistochemistry,
- Microsatellite instability

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References(39)

References

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