The Research of Correlation of Genetic Polymorphisms in IL1RN with Risk of Glioma

Li Guo Lin; Li Chao; Li Feng

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Li Guo Lin , Li Chao , Li Feng . The Research of Correlation of Genetic Polymorphisms in IL1RN with Risk of Glioma[J]. Journal of Kunming Medical University, 2018, 39(04): 47-51.

Citation:

Li Guo Lin , Li Chao , Li Feng . The Research of Correlation of Genetic Polymorphisms in IL1RN with Risk of Glioma[J]. Journal of Kunming Medical University, 2018, 39(04): 47-51.

Li Guo Lin , Li Chao , Li Feng . The Research of Correlation of Genetic Polymorphisms in IL1RN with Risk of Glioma[J]. Journal of Kunming Medical University, 2018, 39(04): 47-51.

Citation:

Li Guo Lin , Li Chao , Li Feng . The Research of Correlation of Genetic Polymorphisms in IL1RN with Risk of Glioma[J]. Journal of Kunming Medical University, 2018, 39(04): 47-51.

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The Research of Correlation of Genetic Polymorphisms in IL1RN with Risk of Glioma

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基金：陕西省科技攻关基金资助项目 (2016SF-110);

Received Date: 2017-11-21

Abstract

Abstract

Objective To investigate the association between single nucleotide polymorphisms (SNPs) in IL1 RN and risk of glioma. Me thods A total of 200 glioma patients and 200 healthy controls were enrolled in Kuangwu Hospital of Tongchuan from January 2012 to December 2016. Blood samples were collected. The genotypes of rs17042888, rs315919, rs928940, rs3181052, rs452204 and rs4252019 were genotyped by Mass ARRAY method, and the association between SNPs with glioma risk was evaluated using SPSS 19.0. Re s ults Comparing the allele frequencies of SNPs, we found the allele "G" of rs315919 and allele "C" of rs4252019 were significantly associated with decreased risk of glioma (rs315919: OR=0.841, 95%CI: 0.712-0.993, P=0.041;rs4252019:OR =0.835, 95% CI: 0.707-0.987, P =0.034) . In the genetic model analysis, we found that under recessive model, carries of G/G genotype of rs315919 have 0.75-fold reduced risk of glioma, compared with carries of T/T and G/T genotypes (OR=0.75, 95%CI: 0.52-0.96, P=0.026) . Under dominant model, carries of C/T and C/C genotypes of rs4252019 have 0.76-fold reduced risk of glioma, compared with carries of T/T genotype (OR=0.76, 95 %CI: 0.59-0.97, P=0.025) . Conclus ion The rs315919 and rs4252019 in IL1 RN were associated with decreased risk of glioma.
- IL1RN,
- Single nucleotide polymorphisms (SNP) ,
- Association study,

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References(23)

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