The Relationship between Vitamin D Receptor (VDR) Gene ApaI, FokI, TaqI, Tru9I Single Nucleotide Polymorphism and Hashimoto's Thyroiditis

Xiang Xi; Wang Yu Ming; Yang Yan Run; Li Wan Bi; Zhang Xian; Yang Cai; Liu Hua

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Xiang Xi , Wang Yu Ming , Yang Yan Run , Li Wan Bi , Zhang Xian , Yang Cai , Liu Hua . The Relationship between Vitamin D Receptor (VDR) Gene ApaI, FokI, TaqI, Tru9I Single Nucleotide Polymorphism and Hashimoto's Thyroiditis[J]. Journal of Kunming Medical University, 2018, 39(04): 88-94.

Citation:

Xiang Xi , Wang Yu Ming , Yang Yan Run , Li Wan Bi , Zhang Xian , Yang Cai , Liu Hua . The Relationship between Vitamin D Receptor (VDR) Gene ApaI, FokI, TaqI, Tru9I Single Nucleotide Polymorphism and Hashimoto's Thyroiditis[J]. Journal of Kunming Medical University, 2018, 39(04): 88-94.

Citation:

Xiang Xi , Wang Yu Ming , Yang Yan Run , Li Wan Bi , Zhang Xian , Yang Cai , Liu Hua . The Relationship between Vitamin D Receptor (VDR) Gene ApaI, FokI, TaqI, Tru9I Single Nucleotide Polymorphism and Hashimoto's Thyroiditis[J]. Journal of Kunming Medical University, 2018, 39(04): 88-94.

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The Relationship between Vitamin D Receptor (VDR) Gene ApaI, FokI, TaqI, Tru9I Single Nucleotide Polymorphism and Hashimoto's Thyroiditis

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资资助项目 (2014FZ047);

Received Date: 2018-01-11

Abstract

Abstract

Objective To investigate the association of Vitamin D receptor gene Apa I, Fok I, Taq I, Tru9 I single nucleotide polymorphism with hashimoto's thyroiditis (HT) . Me thods The single nucleotide polymorphism of VDR gene in 139 (HT group) and 66 normal controls (NT group) were detected by Taq Man fluorescent probe.The genotype frequency and allele frequency and relative clinical data were compared between groups. Re s ults (1) Mean serum 25 (OH) D in HT patients in Gejiu was (18.45±7.60) ng/m L. (2) The level of 25 (OH) D in HT [ (17.66 ±7.91) ng/ml] was significantly lower than that in NT group [ (20.13 ±6.65) ng/m L].25 (OH) D deficiency in NT group (42.42%) was significantly higher than that in HT group (22.30%, P = 0.003) .25 (OH) D deficiency in HT group (70.51%) was significantly higher than that in HT group (51.52%, P = 0.008) . (3) Apa I CC, CA and AA genotype frequencies were 0.51, 0.40 and 0.09 and allele C and allele A frequencies were 0.71 and 0.29;Fok I CC, TC and TT genotype frequencies were 0.28, 0.50 and 0.22 and allele T and allele C frequencies were 0.47 and 0.53;Tru9 I GG, GA and AA genotype frequencies were 0.61, 0.33 and 0.06, and allele G and allele A frequencies were 0.77 and 0.23; The genotype frequency and allele frequency in two groups failed to show statistically significance (P<0.05) (4) According to the analysis of logistic regression, 25 (OH) D insufficient was the risk factor related to the occurrence of HT (OR=1.429, P = 0.033) .Conclus ion People with 25 (OH) D deficiency and insufficiency were widespread in Gejiu. 25 (OH) D deficiency in HT group was significantly higher than that in NT group. 25 (OH) D insufficiency may be the independent risk factor related to the occurrence of HT. VDR Apa I, Taq I, Fok I and Tru9 I single nucleotide polymorphism were not related to HT.
- 25-hydroxy-vitamin D,
- Hashimoto's thyroiditis,
- Vitamin D receptor,
- Gene single nucleotide polymorphism

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References(20)

References

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