Clinical Significance of MIP-1α and VEGF Levels in Serum and CSF of ALS Patients

Li Guo Lin; Li Chao; Li Feng

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Li Guo Lin , Li Chao , Li Feng . Clinical Significance of MIP-1α and VEGF Levels in Serum and CSF of ALS Patients[J]. Journal of Kunming Medical University, 2018, 39(05): 106-110.

Citation:

Li Guo Lin , Li Chao , Li Feng . Clinical Significance of MIP-1α and VEGF Levels in Serum and CSF of ALS Patients[J]. Journal of Kunming Medical University, 2018, 39(05): 106-110.

Li Guo Lin , Li Chao , Li Feng . Clinical Significance of MIP-1α and VEGF Levels in Serum and CSF of ALS Patients[J]. Journal of Kunming Medical University, 2018, 39(05): 106-110.

Citation:

Li Guo Lin , Li Chao , Li Feng . Clinical Significance of MIP-1α and VEGF Levels in Serum and CSF of ALS Patients[J]. Journal of Kunming Medical University, 2018, 39(05): 106-110.

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Clinical Significance of MIP-1α and VEGF Levels in Serum and CSF of ALS Patients

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基金：陕西省科技攻关基金资助项目 (2016SF-110);

Received Date: 2018-01-21

Abstract

Abstract

Objective Through the detection of MIP-1α and VEGF levels in serum and CSF of ALS patients, we evaluated the clinical value of MIP-1 and VEGF levels in ALS patients. Me thods A total of 80 patients with ALS were collected from Kuangwu Hospital of Tongchuanin from Jan, 2012 to Jun, 2015, and 67 patients with non-inflammation neurological diseases were chosen as control group. We obtained CSF and serum samples, and the MIP-1α and VEGF levels were measured by ELISA method. Re s ults The MIP-1α levels in serum and CSF of ALS patients were statistically and significantly higher than those in the control group (P<0.05) .The VEGF levels in serum of ALS patients were statistically and significantly higher than those in the control group (P<0.05) .The VEGF levels in CSF of ALS patients were not higher than those in the control group, statistically insignificant (P >0.05) .MIP-1 alpha and VEGF levels was positively correlated with ALS course. The MIP-1αand VEGF levels of the long duration group were greater than the short duration group (P <0.05) .Conclus ion The rising of MIP-1α and VEGF may indicate an activation of compensatory responses in ALS which suggested that MIP-1 alpha and VEGF are involved in the pathophysiology of amyotrophic lateral sclerosis. We propose that MIP-1α and VEGF may be a useful biomarker witha prognostic and evaluating potential for ALS.
- Amyotrophic lateral sclerosis,
- Macrophage inflammatory protein-1 alpha (MIP-1α) ,
- Vascular endothelial growth factor

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References(18)

References

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