Research Progress of the Relationship of the Expression of TAR DNA/RNA-binding Domain Protein 43 in Neurodegenerative Disease and Brain Injury

Cai Bin; Song Hai; Wang Zhen; Han Xue; Yu Jian Yun

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Cai Bin , Song Hai , Wang Zhen , Han Xue , Yu Jian Yun . Research Progress of the Relationship of the Expression of TAR DNA/RNA-binding Domain Protein 43 in Neurodegenerative Disease and Brain Injury[J]. Journal of Kunming Medical University, 2018, 39(05): 124-127.

Citation:

Cai Bin , Song Hai , Wang Zhen , Han Xue , Yu Jian Yun . Research Progress of the Relationship of the Expression of TAR DNA/RNA-binding Domain Protein 43 in Neurodegenerative Disease and Brain Injury[J]. Journal of Kunming Medical University, 2018, 39(05): 124-127.

Citation:

Cai Bin , Song Hai , Wang Zhen , Han Xue , Yu Jian Yun . Research Progress of the Relationship of the Expression of TAR DNA/RNA-binding Domain Protein 43 in Neurodegenerative Disease and Brain Injury[J]. Journal of Kunming Medical University, 2018, 39(05): 124-127.

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Research Progress of the Relationship of the Expression of TAR DNA/RNA-binding Domain Protein 43 in Neurodegenerative Disease and Brain Injury

Cai Bin ¹,
Song Hai ^1,2,
Wang Zhen ¹,
Han Xue ¹,
Yu Jian Yun ¹

Funds:

基金：国家自然科学基金资助项目 (81360467); 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2013FB104);

Received Date: 2017-09-10

Abstract

Abstract

TAR DNA/RNA-binding domain protein 43 (TDP-43) is a highly conserved and widely expressed nuclear protein. TDP-43 is recognized as a pathological marker protein of amyotrophic lateral sclerosis (ALS) , frontotemporal lobar degeneration (FTLD) and alzheimer disease (AD) .This article discusses the structure and the function of TDP-43 and the relationship of its expression in neurodegenerative disease.Meanwhile, this article emphatically probes into the specific expression andfunction of TDP-43 in acute and chronic brain injury based on the knowledge of its biological characteristics, aiming to explore the feasibility for determining the cause of death and the injury and disability situations by TDP-43 in forensic pathology.
- TDP-43,
- Neurodegenerative disease,
- Forensic pathology,
- Brain injuries

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References(24)

References

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