Lin Huan , Li Cheng Ping , Wu Bing Fen , Ran Li . Progress in the Treatment of Acquired Hemophilia A[J]. Journal of Kunming Medical University, 2018, 39(05): 128-131.
Citation: Lin Huan , Li Cheng Ping , Wu Bing Fen , Ran Li . Progress in the Treatment of Acquired Hemophilia A[J]. Journal of Kunming Medical University, 2018, 39(05): 128-131.

Progress in the Treatment of Acquired Hemophilia A

Funds:

基金: 国家自然科学基金资助项目 (2015FB049); 云南省医疗卫生单位内设研究机构科研基金资助项目 (2017NS047);

  • Received Date: 2017-12-13
  • Acquired hemophilia A is a deficiency disease caused by blood coagulation factor VIII antibodies due to a variety of causes, The disease incidence rate is extremely low, but the mortality rate is high. This disease is often misdiagnosed, resulting in delays in treatment, so early diagnosis and timely treatment is crucial for reducing the mortality. The principle of treatment for the disease is mainly to control acute bleeding, eradicate inhibitor, and treat the primary disease, therefore, rational and personalized choices of treatment are also critical.
  • [1]
    [1]COLLINS P W.Treatment of acquired hemophilia A[J].J Thromb Haemost, 2007, 5 (5) :893-900.
    [2]
    [2]P W C, CHALMERS E, HART D, et al.Diagnosis and management of acquired coagulation inhibitors:a guideline from UKHCDO[J].British Journal of Haematology, 2013, 162 (6) :758-773.
    [3]
    [3]BAUDO F, COLLINS P, HUTHK?HNE A, et al.Management of bleeding in acquired hemophilia A:results from the European Acquired Haemophilia (EACH2) Registry[J].Bjog An International Journal of Obstetrics&Gynaecology, 2012, 119 (12) :1529-1537.
    [4]
    [4]KRUSEJARRES R, KEMPTON C L, BAUDO F, et al.Acquired hemophilia A:Updated review of evidence and treatment guidance[J].American Journal of Hematology, 2017, 92 (7) :695-705.
    [5]周荣富, 王鸿利.获得性血友病的临床研究[J].国际输血及血液学杂志, 2004, 27 (1) :36-40.
    [6]
    [6]LILLICRAP D, SCHIVIZ A, APOSTOL C, et al.Porcine recombinant factor VIII (Obizur;OBI-1;BAX801) :product characteristics and preclinical profile[J].Haemophilia, 2016, 22 (2) :308-317.
    [7]
    [7]MA A D, KESSLER C M, AL-MONDHIRY H A, et al.Use of recombinant activated factor VII for acute bleeding episodes in acquired hemophilia:final analysis from the Hemostasis and Thrombosis Research Society Registry acquired hemophilia study[J].Blood Coagulation&Fibrinolysis An International Journal in Haemostasis&Thrombosis, 2016, 28 (2) :87-116.
    [8]
    [8]SHANG-YI H, WOEI T, SHYUANN-YUH L, et al.A study of 65 patients with acquired hemophilia A in Taiwan[J].Journal of the Formosan Medical Association, 2015, 114 (4) :321-327.
    [9]
    [9]FRANCHINI M.Postpartum acquired factor VIII inhibitors[J].American Journal of Hematology, 2006, 81 (10) :768-773.
    [10]
    [10]COLLINS P, BAUDO F, KNOEBL P, et al.Immunosuppression for acquired hemophilia A:results from the European Acquired Haemophilia Registry (EACH2) [J].Blood, 2012, 120 (1) :47-55.
    [11]
    [11]VAUTIER M, DE B H, CREVEUIL C, et al.Influence of factor VIII level and its inhibitor titer on the therapeutic response to corticosteroids alone in the management of acquired hemophilia:A retrospective single-center study[J].Medicine, 2016, 95 (48) :e5232.
    [12]魏卿, 牛挺.获得性血友病A免疫抑制剂的治疗进展[J].华西医学, 2014, 29 (4) :646-650.
    [13]
    [13]D’ARENA G, GRANDONE E, MINNO M N D D, et al.Acquired hemophilia a successfully treated with rituximab[J].Mediterranean Journal of Hematology&Infectious Diseases, 2015, 7 (1) :e2015024.
    [14]
    [14]PESCOVITZ M D.RITUXIMAB, an anti-cd20 monoclonal antibody:history and mechanism of action[J].American Journal of Transplantation Official Journal of the American Society of Transplantation&the American Society of Transplant Surgeons, 2006, 6 (5 Pt 1) :859-866.
    [15]
    [15]DYKES A C, WALKER I D, LOWE G D O, et al.Combined prednisolone and intravenous immunoglobulin treatment for acquired factor VIII inhibitors:a 2-year review.[J].Haemophilia the Official Journal of the World Federation of Hemophilia, 2001, 7 (2) :160-163.
    [16]
    [16]ZEITLER H, ULRICH-MERZENICH G, HESS L, et al.Treatment of acquired hemopfdlia by the Bonn-Malmo Protocol:Documentation of an in vivo immunomodulating concept[J].Blood, 2005, 105 (6) :2287-2293.
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