Lu Die Qing . Association Analysis between Genetic Polymorphisms of CYP4A11, Apolipoprotein B and E Genes and Essential Hypertension Susceptibility[J]. Journal of Kunming Medical University, 2018, 39(05): 70-77.
Citation: Lu Die Qing . Association Analysis between Genetic Polymorphisms of CYP4A11, Apolipoprotein B and E Genes and Essential Hypertension Susceptibility[J]. Journal of Kunming Medical University, 2018, 39(05): 70-77.

Association Analysis between Genetic Polymorphisms of CYP4A11, Apolipoprotein B and E Genes and Essential Hypertension Susceptibility

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基金: 国家自然科学基金资助项目 (81300115);

  • Received Date: 2018-02-11
  • Objective To investigate the association between single nucleotide polymorphisms (SNPs) in CYP4A11 and Apo B、 Apo E genesandthe risk of essential hypertension. Me thods By means of correlation analysis, this case-controlled study included a total of 350 essential hypertension patients admitted in the first Hospital of Xi'an from June 2012 to December 2016, and another 350 cases with matched ages and sexes enrolled for routine check-ups as the healthy control group. The genotypes of CYP4A11 and Apo B、 Apo E genes were determined by Mass ARRAY method. SPSS 21.0 software was used to determine the correlation between SNPs and the risk of primary hypertension.Re s ults Comparing the allele frequencies of SNPs, we found rs1126742 (OR=1.45, 95 % CI, 1.09-1.92, P =0.008) 、 rs3890011 (OR=1.98, 95 % CI, 1.06-1.85, P =0.001) and rs9332978 (OR=1.54, 95 % CI, 1.27-1.91, P=0.004) on CYP4A11 were significantly associated with an increased risk of essential hypertension; Xba Ⅰ polymorphism in Apo B gene was associated with essential hypertension risks (OR=1.55, 95 % CI, 1.15-2.55, P=0.001) ;ε4 in Apo E gene was also found associated with essential hypertension risks (OR=1.49, 95 % CI, 1.09-2.35, P =0.012) , while ε2 andε3 not associated.Comparing the genotype frequencies of SNPs, we found the GG genotype of rs9332978, TC and CC genotype of rs1126742, CG and GG genotypes of rs3890011 were associated with increased risks of essential hypertension (P <0.05) .The X-X-genotype of Xba Ⅰ in Apo B gene were associated with increased risks of essential hypertension (OR=2.45, 95 % CI, 1.25-3.25, P = 0.035) . The E2/E4、E3/E4、E4/E4 genotype of Apo E were associated with increased risks of essential hypertension (P<0.05) .In the genetic model analysis, we found that the minor allele "A" of rs9332978 was associated with an increased risk of essential hypertension under dominant model (P <0.05) . The minor allele "T" of rs1126742 was associated with increased risks essential hypertension under dominant and recessive models (P<0.05) . Conclus ion Gene polymorphisms of CYP4A11、Apo B and Apo E play an important role in the occurrence and development of essential hypertension.
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  • [1]
    [1]DAWES M, BRETT SE, CHOWIENCZYK PJ, et al.The vasodilator action of nebivolol in forearm vasculature of subjects with essential hypertension[J].British Journal of Clinical Pharmacology, 2015, 48 (3) :460-463.
    [2]
    [2]AGARWAL A, AL E.Genetics of human hypertension[J].Trends in Endocrinology&Metabolism Tem, 2005, 16 (3) :127-133.
    [3]
    [3]WANG X, CHEN J, WANG Q, et al.Association between CACNB2 gene polymorphism and stroke of ethnic Han Chinese in Wenzhou region[J].Journal of Wenzhou Medical University, 2015, 8 (1) :39-41.
    [4]
    [4]KOSTULAS K, HUANG WX, CRISBY M, et al.An angiotensin converting enzyme gene polymorphism suggests a genetic distinction between ischaemic stroke and carotid stenosis[J].European Journal of Clinical Investigation, 2015, 29 (6) :478-483.
    [5]杨夏, 张跃新, 朱滨.ACE基因型与脑中风的相关性文献研究[J].新疆医科大学学报, 2007, 30 (7) :746-748.
    [6]
    [6]JIANG X, SHENG H, LI J, et al.Association between renin-angiotensin system gene polymorphism and essential hypertension:a community-based study[J].Journal of Human Hypertension, 2009, 23 (3) :176.
    [7]
    [7]SOUSA AC, PALMA RDR, PEREIRA A, et al.Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island[J].Medicine, 2017, 96 (42) :e7861.
    [8]伊琳, 顾远晖, 周瑞霞, 等.东乡族原发性高血压血管紧张素转换酶基因多态性[J].兰州大学学报 (医学版) , 2007, 33 (1) :48-50.
    [9]
    [9]MORGAN S.Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls[J].New England Journal of Medicine, 1979, 300 (20) :1142.
    [10]周冰, 何淑兰, 谭武红.花生四烯酸CYP表氧化酶代谢产物EET对心肌病的保护作用[J].国外医学医学地理分册, 2015, 36 (1) :66-70.
    [11]
    [11] GAINER J V, BELLAMINE A, DAWSON E P, et al.Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension[J].Circulation, 2005, 111 (1) :63.
    [12]
    [12]SHAHID S U, COOPER J A.Effect of SORT1, APOB and APOE polymorphisms on LDL-C and coronary heart disease in Pakistani subjects and their comparison with northwick park heart study II[J].Lipids in Health&Disease, 2016, 15 (1) :1-9.
    [13]
    [13]KRAUSE B R.The roles of apolipoproteins B and E in lipid transport and atherosclerosis[J].Drug Development Research, 2010, 6 (2) :155-165.
    [14]郭利伟, 武红艳, 黄艳梅, 等.肿瘤坏死因子α及β基因多态性与河南汉族原发性高血压的相关性[J].新乡医学院学报, 2009, 26 (4) :352-354.
    [15]张旺德, 何燕, 官志忠.e NOS基因多态性与原发性高血压的关系[J].贵阳医学院学报, 2016, 41 (1) :1-4.
    [16]
    [16]GAINER J V, BELLAMINE A, DAWSON E P, et al.Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension[J].Circulation, 2005, 111 (1) :63.
    [17]
    [17]WARD N C, TSAI I J, BARDEN A, et al.A single nucleotide polymorphism in the CYP4F2 but not CYP4A11gene is associated with increased 20-HETE excretion and blood pressure[J].Hypertension, 2008, 51 (5) :1393.
    [18]
    [18]LAFFER C L, GAINER J V, WATERMAN M R, et al.The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension[J].Hypertension, 2008, 51 (3) :767-772.
    [19]
    [19]ZHEN-YAN F U, YI-TONG M A, YANG Y N.Association between the SNPs of human CYP4A11 gene and essential hypertension[J].Journal of Xinjiang Medical University, 2008.
    [20]
    [20]PHILLIPS C M, GOUMIDI L, BERTRAIS S, et al.Gene-nutrient interactions and gender may modulate the association between Apo A1 and Apo B gene polymorphisms and metabolic syndrome risk[J].Atherosclerosis, 2011, 214 (2) :408-414.
    [21]
    [21]HEIDARI M M, KHATAMI M, HADADZADEH M, et al.Polymorphisms in NOS3, MTHFR, APOB and TNF-αgenes and risk of coronary atherosclerotic lesions in iranian patients[J].Research in Cardiovascular Medicine, 2015, 5 (1) :e29 134.
    [22]
    [22]TANG LI YUAN, WANG XIAO TONG, KANG Y U.Correlative analysis of apolipoprotein B、E gene polymorphism and several common diseases in southern area of Zhejiang Province[J].Journal of Wenzhou Medical College, 2007, 9 (2) :27-31.
    [23]
    [23]CHEEMA A N, BHATTI A, WANG X, et al.APOE Gene Polymorphism and Risk of Coronary Stenosis in Pakistani Population[J].Biomed Research International, 2015, 2015 (15) :58-65.
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