Association Analysis between Genetic Polymorphisms of CYP4A11, Apolipoprotein B and E Genes and Essential Hypertension Susceptibility

Lu Die Qing

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Lu Die Qing . Association Analysis between Genetic Polymorphisms of CYP4A11, Apolipoprotein B and E Genes and Essential Hypertension Susceptibility[J]. Journal of Kunming Medical University, 2018, 39(05): 70-77.

Citation:

Lu Die Qing . Association Analysis between Genetic Polymorphisms of CYP4A11, Apolipoprotein B and E Genes and Essential Hypertension Susceptibility[J]. Journal of Kunming Medical University, 2018, 39(05): 70-77.

Citation:

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Association Analysis between Genetic Polymorphisms of CYP4A11, Apolipoprotein B and E Genes and Essential Hypertension Susceptibility

Lu Die Qing

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基金：国家自然科学基金资助项目 (81300115);

Received Date: 2018-02-11

Abstract

Abstract

Objective To investigate the association between single nucleotide polymorphisms (SNPs) in CYP4A11 and Apo B、 Apo E genesandthe risk of essential hypertension. Me thods By means of correlation analysis, this case-controlled study included a total of 350 essential hypertension patients admitted in the first Hospital of Xi'an from June 2012 to December 2016, and another 350 cases with matched ages and sexes enrolled for routine check-ups as the healthy control group. The genotypes of CYP4A11 and Apo B、 Apo E genes were determined by Mass ARRAY method. SPSS 21.0 software was used to determine the correlation between SNPs and the risk of primary hypertension.Re s ults Comparing the allele frequencies of SNPs, we found rs1126742 (OR=1.45, 95 % CI, 1.09-1.92, P =0.008) 、 rs3890011 (OR=1.98, 95 % CI, 1.06-1.85, P =0.001) and rs9332978 (OR=1.54, 95 % CI, 1.27-1.91, P=0.004) on CYP4A11 were significantly associated with an increased risk of essential hypertension; Xba Ⅰ polymorphism in Apo B gene was associated with essential hypertension risks (OR=1.55, 95 % CI, 1.15-2.55, P=0.001) ;ε4 in Apo E gene was also found associated with essential hypertension risks (OR=1.49, 95 % CI, 1.09-2.35, P =0.012) , while ε2 andε3 not associated.Comparing the genotype frequencies of SNPs, we found the GG genotype of rs9332978, TC and CC genotype of rs1126742, CG and GG genotypes of rs3890011 were associated with increased risks of essential hypertension (P <0.05) .The X-X-genotype of Xba Ⅰ in Apo B gene were associated with increased risks of essential hypertension (OR=2.45, 95 % CI, 1.25-3.25, P = 0.035) . The E2/E4、E3/E4、E4/E4 genotype of Apo E were associated with increased risks of essential hypertension (P<0.05) .In the genetic model analysis, we found that the minor allele "A" of rs9332978 was associated with an increased risk of essential hypertension under dominant model (P <0.05) . The minor allele "T" of rs1126742 was associated with increased risks essential hypertension under dominant and recessive models (P<0.05) . Conclus ion Gene polymorphisms of CYP4A11、Apo B and Apo E play an important role in the occurrence and development of essential hypertension.
- Essential hypertension,
- CYP4A11,
- ApoB,
- ApoE,
- Ggene polymorphisms

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References(23)

References

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