The Changes of Hepatitis C Virus Gene Subtypes and RNA Loads in the Development of Chronic Hepatitis C Patients in Yunnan

Shi Xin Huan; Tang Rui Zhu; Liu Zi Jie; Lu Yan Zhou; Li Huan

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Shi Xin Huan , Tang Rui Zhu , Liu Zi Jie , Lu Yan Zhou , Li Huan . The Changes of Hepatitis C Virus Gene Subtypes and RNA Loads in the Development of Chronic Hepatitis C Patients in Yunnan[J]. Journal of Kunming Medical University, 2018, 39(06): 57-61.

Citation:

Shi Xin Huan , Tang Rui Zhu , Liu Zi Jie , Lu Yan Zhou , Li Huan . The Changes of Hepatitis C Virus Gene Subtypes and RNA Loads in the Development of Chronic Hepatitis C Patients in Yunnan[J]. Journal of Kunming Medical University, 2018, 39(06): 57-61.

Citation:

Shi Xin Huan , Tang Rui Zhu , Liu Zi Jie , Lu Yan Zhou , Li Huan . The Changes of Hepatitis C Virus Gene Subtypes and RNA Loads in the Development of Chronic Hepatitis C Patients in Yunnan[J]. Journal of Kunming Medical University, 2018, 39(06): 57-61.

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The Changes of Hepatitis C Virus Gene Subtypes and RNA Loads in the Development of Chronic Hepatitis C Patients in Yunnan

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2017FE468 (-047) ];

Received Date: 2018-02-17

Abstract

Abstract

Objective To investigate the changes of hepatitis C virus (HCV) gene subtypes and RNA loads in chronic hepatitis C, HCV-related liver cirrhosis and HCV-related hepatocellular carcinoma patients in Yunnan. Me thods 241 patients were enrolled at the First Affiliated Hospital of Kunming Medical University (Yunnan, China) from January 2016 to April 2017. Among them, 169 patients were with chronic hepatitis C, 56 patients with HCV-related liver cirrhosis and 16 patients with HCV-related hepatocellular carcinoma. HCV gene subtype and RNA loads were measured using the Polymerase Chain Reaction-fluorescence probe method. Re s ults In the chronic hepatitis C group, there were 47 subtype 3 b cases (27.81%) . 17 cases of HCV-related liver cirrhosis were subtype 1 b (30.36%) ;5 patients with HCV-related hepatocellular carcinoma were subtype 3 b (31.25%) .There was no statistical difference distribution of the genotype among the three groups (P>0.05) .The HCV RNA loads of the chronic hepatitis C group, HCV-related liver cirrhosis group and HCV-related hepatocellular carcinoma group were (332±114) copies/m L, (189±73) copies/m L and (152±56) copies/m L respectively.The difference among three groups were significant (P <0.01) .The chronic hepatitis C group was significantly higher than the other two groups, and the differences were statistically significant (P<0.01) . But no significant difference of HCV RNA loads was found between HCV-related liver cirrhosis and HCV-related hepatocellular carcinoma group (t = 0. 65, P<0.05) . Conclus ion In Yunnan, 3 b was main genotype in chronic hepatitis C patients and 1 b was main genotype in HCV-related liver cirrhosis, 3 b was main genotype in HCV-related hepatocellular carcinoma. HCV RNA loads tend to decrease in the progress that chronic hepatitis C develops into HCV-related liver cirrhosis and HCV-related hepatocellular carcinoma.
- Hepatitis c virus,
- RNA load,
- Gene subtype,
- Chronic hepatitis C,
- HCV-related liver cirrhosis,
- HCV-related hepatocellular carcinoma

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References(18)

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