The Value of T-SPOT.TB in Evaluating Treatment Effect of Tuberculous Vertebral Osteomyelitis

Sun Yu Peng; Zhang Chun Qiang; Du Kai Li; He Shao Bo; Guo Pei Yu; Zhao Run Min

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Article Navigation > Journal of Kunming Medical University > 2018 > 39(06): 86-90

Sun Yu Peng , Zhang Chun Qiang , Du Kai Li , He Shao Bo , Guo Pei Yu , Zhao Run Min . The Value of T-SPOT.TB in Evaluating Treatment Effect of Tuberculous Vertebral Osteomyelitis[J]. Journal of Kunming Medical University, 2018, 39(06): 86-90.

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Sun Yu Peng , Zhang Chun Qiang , Du Kai Li , He Shao Bo , Guo Pei Yu , Zhao Run Min . The Value of T-SPOT.TB in Evaluating Treatment Effect of Tuberculous Vertebral Osteomyelitis[J]. Journal of Kunming Medical University, 2018, 39(06): 86-90.

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The Value of T-SPOT.TB in Evaluating Treatment Effect of Tuberculous Vertebral Osteomyelitis

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2013FZ269;2014FB025); 云南省骨科研究所内设机构基金资助项目 (2016NS022;2017NS024);

Received Date: 2018-02-08

Abstract

Abstract

Objective To investigate the treatment evaluating value of ESAT-6 and CFP-10 in T-SPOT.TB kit for tuberculous vertebral osteomyelitis.Me dthods This retrospective study analyzed 29 cases diagnosed as TVO in the First Affiliated Hospital of Kunming Medical University from January 2013 to January 2016. All cases were the first-time consultancy. The Wilcoxon-singed-rank-test and chi-square test were used to analyze the changes of ESAT-6 and CFP-10 in the procedure of treatment. The linear-regression analysis was used to analyze the relationship between ESR, CRP, VAS and two specific antigens.Re s ults The pretherapeutic spot counts of ESAT-6 and CFP-10 were compared with the first and the last follow-up respectively. The results of two antigenic spots change showed a higher consistency (P<0.05) .The positive rates of CFP-10 at the prior treatment, the first follow-up and the last follow-up were 86.20%, 79.31% and 58.62% respectively. The result of chi-square test showed a higher consistency (P <0.05) . ESAT-6 only correlated with VAS. CFP-10 had the relationship with VAS and ESR. But all of these relativities were weak.Conclus ion The decrease in the spot counts of ESAT-6 and CFP-10 suggest that the treatment is effective, and CFP-10 may be one available index to evaluate the treatment effect.
- T-SPOT.TB,
- Tuberculous vertebral osteomyelitis,
- ESAT-6,
- CFP-10,
- Treatment

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References(18)

References

[1]	[1]DENKINGER C M, DHEDA K, PAI M.Guidelines on interferon-gamma release assays for tuberculosis infection:concordance, discordance or confusion[J].Clin Microbiol Infect, 2011, 17 (6) :806-814.
[2]	[2]AHMAD S.New approaches in the diagnosis and treatment of latent tuberculosis infection[J].Respir Res, 2010, 11 (1) :169.
[3]李宝田, 焦云龙, 孙文星.T-SPOT.TB检测在脊柱结核诊断中的应用[J].中国骨科临床与基础研究杂志, 2015, 07 (2) :74-78.
[4]袁凯, 吴雪琼, 张强, 等.结核杆菌抗原特异性γ干扰素释放试验在脊柱结核辅助诊断中的应用研究[J].实用医学杂志, 2013, 29 (14) :2314-2316.
[5]华裕忠, 程绍云, 姜国红, 等.结核菌感染T细胞干扰素释放检测在脊柱结核快速诊断中的应用[J].中华医学杂志, 2016, 96 (27) :2179-2181.
[6]张瑛, 孙亚蒙, 徐欣晖, 等.结核感染T细胞斑点试验在结核性疾病中的诊断价值[J].中华临床医师杂志, 2010, 4 (12) :2431-2434.
[7]吴阶平, 裘法祖, 吴孟超, 等.黄家驷外科学[M].第7版.北京:人民卫生出版社, 2008:65-70.
[8]郭培宇, 李佩明, 张春强, 等.改良标准化疗方案治疗脊柱结核的疗效分析[J].昆明医科大学学报, 2015, 36 (2) :54-57.
[9]	[9]NICKERSON EK, SINHA R.Vertebral osteomyelitis in adults:an update[J].Br Med Bull, 2016, 117 (1) :121-138.
[10]陶学芳, 王华钧, 王建华, 等.T细胞斑点试验在肺结核诊断和疗效评价中的意义[J].中华临床感染病杂志, 2012, 05 (4) :221-224.
[11]陶学芳, 王建华, 李永兴, 等.结核感染T细胞酶联免疫斑点试验在肺结核及肺外结核诊断中的价值[J].浙江预防医学, 2012, 24 (11) :4-7.
[12]何紫琪, 李从荣.结核感染T细胞斑点试验对结核病治疗效果的监测价值[J].海南医学, 2016, 27 (12) :1923-1925.
[13]	[13]LEUNG C C, YAM WC, HO P L, et al.T-Spot.TB outperforms tuberculin skin test in predicting development of active tuberculosis among household contacts[J].Respirology, 2015, 20 (3) :496-503.
[14]	[14]GUPTA D, AGARWAL R, AGGARWAL A N, et al.Immune responses to mycobacterial antigens in sarcoidosis:a systematic review[J].Indian J Chest Dis Allied Sci, 2011, 53 (1) :41-49.
[15]	[15]HARARI A, VALLELIAN F, MEYLAN P R, et al.Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence[J].Journnal of Immunology, 2005, 174 (2) :1037-1045.
[16]	[16]WELIN A, EKLUND D, STENDAHL O, et al.Human macrophages infected with a high burden of ESAT-6-expressing M.tuberculosis undergo caspase-1-and cathepsin B-independent necrosis[J].PLo S One, 2011, 6 (5) :e20302.
[17]	[17]AIKEN A M, HILL P C, FOX A, et al.Reversion of the ELISPOT test after treatment in Gambian tuberculosis cases[J].Bmc Infectious Diseases, 2006, 6 (1) :1-6.
[18]	[18]EWER K, MILLINGTON K A, DEEKS J J, et al.Dynamic Antigen-specific T-Cell Responses after Point-Source Exposure to Mycobacterium tuberculosis[J].American Journal of Respiratory and Critical Care Medicine, 2006, 174 (7) :831-839.

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