Clinical Effect of Autologous Peripheral Blood Stem Cell Transplantation Combined with Interventional Therapy in Treatment of Chronic Lower Limb Ischemia

Zhang Rui Peng; Wang Hui; Dai Yi; Zhang Hong; Li Wei; Wang Xiao Jun; Gao Zeng Zhan

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Article Navigation > Journal of Kunming Medical University > 2018 > 39(07): 101-105

Zhang Rui Peng , Wang Hui , Dai Yi , Zhang Hong , Li Wei , Wang Xiao Jun , Gao Zeng Zhan . Clinical Effect of Autologous Peripheral Blood Stem Cell Transplantation Combined with Interventional Therapy in Treatment of Chronic Lower Limb Ischemia[J]. Journal of Kunming Medical University, 2018, 39(07): 101-105.

Citation:

Zhang Rui Peng , Wang Hui , Dai Yi , Zhang Hong , Li Wei , Wang Xiao Jun , Gao Zeng Zhan . Clinical Effect of Autologous Peripheral Blood Stem Cell Transplantation Combined with Interventional Therapy in Treatment of Chronic Lower Limb Ischemia[J]. Journal of Kunming Medical University, 2018, 39(07): 101-105.

Citation:

Zhang Rui Peng , Wang Hui , Dai Yi , Zhang Hong , Li Wei , Wang Xiao Jun , Gao Zeng Zhan . Clinical Effect of Autologous Peripheral Blood Stem Cell Transplantation Combined with Interventional Therapy in Treatment of Chronic Lower Limb Ischemia[J]. Journal of Kunming Medical University, 2018, 39(07): 101-105.

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Clinical Effect of Autologous Peripheral Blood Stem Cell Transplantation Combined with Interventional Therapy in Treatment of Chronic Lower Limb Ischemia

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基金：陕西省科技攻关资助项目 (2014K11-02-01-08);

Received Date: 2018-02-19

Abstract

Abstract

Objective To investigate the clinical effect of percutaneous transluminal angioplasty (PTA) combined with autologous peripheral blood stem cell transplantation (ABSCT) in treating chronic lower limb ischemia.Me thods A total of 48 patients with chronic lower limb ischemia were voluntarily allocated into 3 groups: 19 patients treated with ABSCT combined with PTA, named as combined treatment group; 10 patients treated with ABSCT alone, named as single ABSCT group; and 19 patients treated with PTA alone, named as single PTA group. Patients in 3 groups received conventional therapy. Limb pain, cold feeling, intermittent claudication, ankle brachial index (ABI) and the number of collateral vessel formation of patients in 3 groups were assessed before and after treatment. Comparison of clinical effects was performed in 3 groups.Re s ults Limb pain scores, cold feeling scores and intermittent claudication scores of the patients in 3 groups significantly decreased after treatment (P <0.05) . ABI score and the number of collateral vessel formation significantly increased (P<0.05) . The combined treatment group showed obvious improvement in all the measured assessmentindicators (P<0.05) . The total effective rate of combined treatment group was 89.5% while that in PTA group and ABSCT group were 78.9% and 60.0%, respectively. The total effective rate in combined treatment group was higher than that in both PTA group and ABSCT group (P <0.05) . Conclus ion When treating chronic lower limb ischemia, combination use of PTA and transplantation of ABSCT is safe and effective, and its treatment effect is superior to single PTA as well as single ABSCT.
- Chronic lower limb ischemia,
- ABSCT,
- Percutaneous transluminal angioplasty

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References(17)

References

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