Correlation study of the Predictive Value of Beta-trace Protein to Contrast-induced Nephropathy after Coronary Intervention

Miao Wen Qing; Wang Yu; Yang Jun; Zhang Yi Hong; Tian Qing; Duan Hui Xian; Zhao Zhong Wen; Wang Yan; Yang Xing Hu

Article Contents

Article Navigation > Journal of Kunming Medical University > 2018 > 39(07): 114-118

Miao Wen Qing , Wang Yu , Yang Jun , Zhang Yi Hong , Tian Qing , Duan Hui Xian , Zhao Zhong Wen , Wang Yan , Yang Xing Hu . Correlation study of the Predictive Value of Beta-trace Protein to Contrast-induced Nephropathy after Coronary Intervention[J]. Journal of Kunming Medical University, 2018, 39(07): 114-118.

Citation:

Miao Wen Qing , Wang Yu , Yang Jun , Zhang Yi Hong , Tian Qing , Duan Hui Xian , Zhao Zhong Wen , Wang Yan , Yang Xing Hu . Correlation study of the Predictive Value of Beta-trace Protein to Contrast-induced Nephropathy after Coronary Intervention[J]. Journal of Kunming Medical University, 2018, 39(07): 114-118.

Citation:

Miao Wen Qing , Wang Yu , Yang Jun , Zhang Yi Hong , Tian Qing , Duan Hui Xian , Zhao Zhong Wen , Wang Yan , Yang Xing Hu . Correlation study of the Predictive Value of Beta-trace Protein to Contrast-induced Nephropathy after Coronary Intervention[J]. Journal of Kunming Medical University, 2018, 39(07): 114-118.

PDF( 362 KB)

Correlation study of the Predictive Value of Beta-trace Protein to Contrast-induced Nephropathy after Coronary Intervention

Funds:

基金：北京力生心血管健康基金会领航基金资助基目 (LHJJ20158821);

Received Date: 2018-03-19

Abstract

Abstract

Objective To investigate the correlation of the concentration of blood/urine beta-trace protein (βTP) in the prediction of contrast-induced nephropathy. Methods This study enrolled 88 patients with interventional diagnosis or treatment from september to December 2016 in the first hospital of Kunming and the patients were divided into two groups: CIN group (nn = 7) and non-CIN group (n = 81) . The concentration of blood/urine βTP was measured by ELISA method and the results was analysed with SPSS.Re s ults There was significant difference in the level of blood βTP before the operation, 2 h after operation and 24 h after the operation between the two groups (P<0.05) , so was that in the level of urine βTP (P<0.05) . The area under ROC curve (AUC) of blood βTP 2 h after the operation was 0.761, the diagnostic value was 567.568, and the sensitivity and specificity were 71.4% and 81.5% while the area of ROC curve (AUC) of urine βTP 2 h after the operation was0.967, the diagnostic value was 1428.893, and the sensitivity and specificity were 100% and 97.5%.Conclus ion The concentration of blood/urine βTP 2 h after the operation can be used as a new indicator to predict contrast-induced nephropathy. The sensitivity and specificity of urine βTP is better than those of blood βTP, and urine samples are easier to be collected than blood samples.
- Beta-trace protein,
- Coronary heart disease,
- Contrast-induced nephropathy

FullText(HTML)

References(11)

References

[1]	[1]SUDARSKY D, NIKOLSKY E.Contrast-induced nephropathy in interventional cardiology[J].Int J Nephrol Renovasc Dis, 2011, 4 (1) :85-99.
[2]	[2]HOFFMANN A, NIMTZ M, CONRADT H S.Molecular characterization of beta-trace protein in human serum and urine:A potential diagnostic marker for renal diseases[J].Glycobiology, 1997, 7 (4) :499-506.
[3] 中华医学会心血管病分会含碘对比剂在心血管疾病中临床应用的专家共识 (2012) [J].中华心血管病杂志, 2013, 41 (2) :94-98.
[4]陈文, 王又平, 王相智.影响造影剂肾病发病的危险因素分析[J].山东医药, 2010, 50 (41) :99-100.
[5]	[5]MAUTONE, BROWNJ R.Contrast-induced nephropathy in patients undergoing elective and urgent procedures[J].J Interv Cardiol, 2010, 23 (1) :78-85.
[6]	[6]ORENES-PINERO E, MANZANO-FERNANDEZ S;LOPEZ-CUENCA A, et al.β-Trace protein:from GFR marker to cardiovascular risk predictor[J].Clin J Am Soc Nephrol, 2013, 8 (5) :873-881.
[7]	[7]VYNCKIER L L, FLOR K M, DELANGHE S E, et al.Urinary beta-trace protein as a new renal tubular marker[J].Clin Chem, 2009, 55 (6) :1241-1243.
[8]张嘉惠, 倪兆慧.B一痕迹蛋白作为新生物标记评估肾功能及心血管风险[J].中国血液净化, 2014, 13 (7) :526-530.
[9]	[9]PO..GE U, GERHARDT T M, STOFFEL-WAGNER B, et al.Beta-Trace protein is an alternative marker for glomerular filtration rate in renal transplantation patients[J].Clin Chem, 2005, 51 (8) :1531-1533.
[10]	[10]DAJAK M, IGNJATOVIC S, STOJIMIROVIC B, et al.Urinary beta-trace protein as a tubular marker of renal dysfunction in patients with chronic kidney disease[J].Clin chim Acta, 2010, 411 (15-16) :1154-1155.
[11]	[11]ASTOR B C, SHAFI T, HOOGEVEEN R C, et al.Novel markers of Kidney function as predictors of ESRD, cardiovascular disease, and mortality in the general population[J].Am J Kidney Dis, 2012, 59 (5) :653-662.

Relative Articles(20)

Relative Articles

[1]	Wenxiu XU, Xiaofeng MO, Xiangmin YANG, Silu YANG, Fan WU, Te LI. Application of Logistic Regression and Decision Tree Model in Prediction of Adverse Reactions of Iodinated Contrast Medium. Journal of Kunming Medical University, 2024, 45(9): 70-75. doi: 10.12259/j.issn.2095-610X.S20240911
[2]	Jiajia XUE, Xiaoxiao WANG, Xu WANG, Yuanyuan SUN, Honglu ZHU. Application of Thyroid Function Indicators Combined with Transcranial Doppler Ultrasound and Carotid Ultrasound in the Assessment of Vascular Stenosis in Atherosclerotic Cerebral Infarction. Journal of Kunming Medical University, 2024, 46(): 1-7.
[3]	Yao YANG, Jianxiong LIU, Yun ZHANG, Fanyi KONG, Shixiang LIU. Relationships between Large Artery Atherosclerotic Stroke and Cardiac Function. Journal of Kunming Medical University, 2022, 43(11): 107-111. doi: 10.12259/j.issn.2095-610X.S20221126
[4]	Wen-bin ZHANG, Dan HAN, Yang TIAN, Wei ZHAO. The Correlation between Epicardial Adipose Tissue and Coronary Artery Atherosclerosis with the Dual-source CT. Journal of Kunming Medical University, 2021, 42(8): 111-117. doi: 10.12259/j.issn.2095-610X.S20210820
[5]	Wen-qing MIAO, Yu WANG, Jun YANG, Ni-ni TIAN, Hui-xian DUAN, Xiao-li ZHAO. Correlation Study of Blood Preβ1-HDL Predictive Value of Coronary Artery Disease Severity in Patients with Coronary Heart Disease. Journal of Kunming Medical University, 2021, 42(5): 114-119. doi: 10.12259/j.issn.2095-610X.S20210521
[6]	Xiong Xin , Yang Qi Kun , Liu Kai , Qu Yong Qiang , Lei Pu Ping , Wang Shang Wen , Li Yu Hua . . Journal of Kunming Medical University, 2020, 41(08): 145-149.
[7]	Wang Yu , Miao Wen Qing , Guang Xue Feng , Yang Jun , Zhang Yi Hong , Tian Qing , Duan Hui Xian , Wang Yan . Prediction of the Severity of Coronary Artery Disease by Plasma FKN Concentration. Journal of Kunming Medical University, 2017, 38(04): 127-131.
[8]	Chang Lu . . Journal of Kunming Medical University,
[9]	Fu Zhong Yang . . Journal of Kunming Medical University,
[10]	Lu Fang Li . . Journal of Kunming Medical University,
[11]	Pang Xing Mei . . Journal of Kunming Medical University,
[12]	Wang Dan . . Journal of Kunming Medical University,
[13]	Zhu Ya Juan . . Journal of Kunming Medical University,
[14]	Zhang Tao . . Journal of Kunming Medical University,
[15]	Shen Zhi Qiang . . Journal of Kunming Medical University,
[16]	Shen Zhi Qiang . . Journal of Kunming Medical University,
[17]	Chen Shi Gui . . Journal of Kunming Medical University,
[18]	Nie Zhi . . Journal of Kunming Medical University,
[19]	. Therapeutic Effect of PAS Combination Therapy on 40 Patients with Atherosclerosis. Journal of Kunming Medical University,
[20]	. Evaluation of Atherosclerosis in Rheumatoid Arthritis Patients with High Lipid Levels by Ultrasonography. Journal of Kunming Medical University,