Research Progress of Transcranial Focused Ultrasound in Combination with Microbubbles in Treating Open Blood-Brain Barrier

Zhang Liu Ying; Xu Xuan; Chen Mo Xian; Ao Li Juan

Article Contents

Article Navigation > Journal of Kunming Medical University > 2018 > 39(07): 124-128

Zhang Liu Ying , Xu Xuan , Chen Mo Xian , Ao Li Juan . Research Progress of Transcranial Focused Ultrasound in Combination with Microbubbles in Treating Open Blood-Brain Barrier[J]. Journal of Kunming Medical University, 2018, 39(07): 124-128.

Citation:

Zhang Liu Ying , Xu Xuan , Chen Mo Xian , Ao Li Juan . Research Progress of Transcranial Focused Ultrasound in Combination with Microbubbles in Treating Open Blood-Brain Barrier[J]. Journal of Kunming Medical University, 2018, 39(07): 124-128.

Citation:

Zhang Liu Ying , Xu Xuan , Chen Mo Xian , Ao Li Juan . Research Progress of Transcranial Focused Ultrasound in Combination with Microbubbles in Treating Open Blood-Brain Barrier[J]. Journal of Kunming Medical University, 2018, 39(07): 124-128.

PDF( 201 KB)

Research Progress of Transcranial Focused Ultrasound in Combination with Microbubbles in Treating Open Blood-Brain Barrier

Funds:

基金：国家自然科学基金资助项目 (81660381);

Received Date: 2018-02-17

Abstract

Abstract

The blood-brain barrier (BBB) is a special protective barrier existing between the blood and brain tissues. The primary function of BBB is to selectively prevent most solutes in the blood from invading the central nervous system (CNS) and avoid damage to CNS, thereby effectively maintaining the stability and normal physiological function of CNS environment. However, in some CNS diseases, BBB also blocks most therapeutic drugs from entering the central nervous system, which would affect the treatment effect. Therefore, how to open BBB safely and reversibly has become the focus of research in recent years. Recent studies have shown that focused ultrasound-microbubbles therapy (FUS-MB) can open BBB transiently, locally, reversibly and noninvasively, and open up a new approach for targeted therapy of intracranial diseases. This article reviewed relevant research progress and mechanism of BBB opening with FUS-MB technology.
- Blood brain barrier,
- Focused ultrasound,
- Microbubbles

FullText(HTML)

References(36)

References

[1]	[1]TIMBIE K F, MEAD B P, PRICE R J.Drug and gene delivery across the blood-brain barrier with focused ultrasound[J].Controll Release, 2015, 219 (10) :61-75.
[2]徐兵, 张俞, 杜久林.血脑屏障的研究进展[J].生理学报Acta Physiologica Sinica, 2015, 68 (3) :306-322.
[3]	[3]ZHAO Z, NELSON A R, BETSHOLTZ C, et al.Establishment and dysfunction of the blood-brain barrier[J].Cell, 2015, 163 (5) :1064-1078.
[4]	[4]BAUER H C, KRIZBAI I A, BAUER H, et al.“You Shall Not Pass”-tight junctions of the blood-brainbarrier[J].Front in Neurosci, 2014, 8 (392) :1-21.
[5]	[5]HANSKE S, DYRNA F, BECHMANN I, et al.Different segments of the cerebral vasculature reveal specific endothelial specifications, while tight junction proteins appear equally distributed[J].Brain Struct Funct, 2017, 222 (3) :1179-1192.
[6]	[6]DIAZ R, MIGUEL P M, DENIZ B F, et al.Environmental enrichment attenuates the blood brain barrier dysfunction induced by the neonatal hypoxia-ischemia[J].Int J Dev Neurosci, 2016, 53 (16) :35-45.
[7]	[7]LIAO Z, YANG Z, PIONTEK A, et al.Specific binding of a mutated fragment of Clostridium perfringens enterotoxin to endothelial claudin-5 and its modulation of cerebral vascular permeability[J].Neuroscience, 2016, 327 (16) :53-63.
[8]	[8]BETSHOLTZ C.Physiology:Double function at the blood-brain barrier[J].Nature, 2014, 509 (7501) :432-433.
[9]徐猛, 李延锋, 杨本强, 等.血脑屏障开放及其灌注成像的影响评估[J].中国CT和MRI杂志, 2014, 12 (5) :109-115.
[10]	[10]SHOICHET M S, WINN S R.Cell delivery to the central nervous system[J].Adv Drug Deliv Rev, 2000, 42 (1) :81-102.
[11]	[11]BURGESS A, HYNYNEN K.Noninvasive and targeted drug delivery to the brain using focused ultrasound[J].Acs Cheml Neurosc, 2013, 4 (4) :519-526.
[12]	[12]FAN C H, YEH C K.Microbubble-enhanced focused ultrasound-induced blood-brain barrier opening for local and transient drug delivery in central nervous system disease[J].J Ultras Med, 2014, 22 (4) :183-193.
[13]	[13]MCDANNOLD N, ARYANITIS C D, VYKHODTSEVA N, et al.Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles:safety and efficacy evaluation in rhesus macaques[J].Cancer Res, 2012, 72 (14) :3652-3663.
[14]陈高舒, 郭瑾璇, 杨细飞, 等.低频超声联合微泡治疗阿尔茨海默症的研究进展[J].生物医学工程学进展, 2015, 36 (3) :153-158.
[15]	[15]REBECCA M, NISBET, ANN VAN DER JEUGD, et al.Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse mode[J].Brain 2017, 140 (5) :1220-1230.
[16]	[16]BARNARD J W, FRY W J, FRY F J, et al.Effects of high intensity ultrasound on the central nervous system of the cat[J].The Journal of Comparative Neurology, 1955, 103 (3) :459-484.
[17]	[17]BAKAY L, LEE J C, LEE G C, et al.Experimental cerebral concussion.Part1:an electron microscopic study[J].J Nerosurg, 1977, 47 (4) :525-531.
[18]	[18]HYNYNEN K, MCDANNOLD N, VYKHODTSEVA N, et al.Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits[J].Radiology, 2001, 220 (3) :640-646.
[19]	[19]LAMMERTINK B, DECKERS R, STORM G, et al.Duration of ultrasound-mediated enhanced plasma membrane permeability[J].Int J Pharm, 2015, 482 (1/2) :92-98.
[20]	[20]JORDAO J F, THEVENOT E, MARKHAM-COULTES K, et al.Amyloid-beta plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound[J].Experimental neurology, 2013, 248 (16) :16-29.
[21]	[21] CHEN W S, HSIEH H Y, PITT W G, et al.Focused ultrasound-induced blood-brain barrier opening for non-viral, non-invasive, and targeted gene delivery[J].Journal of Controlled Release, 2015, 212 (19) :1-9.
[22]王敏, 沈圆圆, 汪天富, 等.聚焦超声联合微泡开放血脑屏障机制及监测方法的研究进展[J].2016, 37 (4) :198-203.
[23]	[23]LU M, SHI Y, FANG L, et al.Enhanced-cavitation heating protocols in focused ultrasound surgery with broadband split-focus approach[J].IEEE Tran Ultrason, Ferroelectr Freq Control, 2014, 61 (4) :631-646.
[24]	[24]BAZAN-PEREGRINO M, RIFAI B, CARLISLE R C, et al.Cavitation-enhanced delivery of a replicating oncolytic adenovirus to tumors using focused ultrasound[J].J Control Release, 2013, 169 (1/2) :40-47.
[25]	[25]TAM NHAN, ALISON BURGESS, EUNICE E, et al.Drug delivery to the brain by focused ultrasound induced blood-brain barrier disruption:Quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy[J].J Control Release, 2013, 172 (28) :274-280.
[26]罗利红, 吴凤林, 王宝平, 等.超声致微泡声孔效应增强兔VX2肿瘤细胞通透性的适宜声学参数[J].J South Med Univ, 2103, 33 (9) :1377-1381.
[27]	[27]MCDANNOLD N, VYKHODTSEVA N, JOLESZ FA, et al.MRI investigation of the threshold for thermally induced blood-brain disruption and brain tissue danage in the rabbit brain[J].Magn Reson Med, 2004, 51 (5) :913-923.
[28]	[28]ZHOU Q L, CHEN Z Y, WANG Y X.Ultrasound-mediated local drug and gene delivery using nanocarriers[J].Bio Med Research International, 2014, 2014 (10) :963891
[29]	[29]SAMIOTAKI G, KONOFAGOU E E.Dependence of the reversibility of focused-ultrasound-induced blood-brain barrier opening on pressure and pulse length in vivo[J].IEEE Trans Ultrason Ferroelectr Freq Control, 2013, 60 (11) :2257-2265.
[30]	[30]SAMIOTAKI G, VLACHOS F, TUNG Y S, et al.A quantitative pressure and microbubble-size dependence study of focused ultrasound-induced blood-brain barrier opening reversibility in vivo using MRI[J].Magn Reson Med, 2012, 67 (3) :769-777.
[31]	[31]NBURGESS S, HYNYNEN K, Drug delivery across the blood-brain barrier using focused ultrasound, Expert Opin[J].Drug Deliv, 2014, 11 (5) :711-721.
[32]	[32]CHUNG-YIN LIN, HAN-YI HSIEH, WILLIAM G, et al.Focused ultrasound-induced blood-brain barrier opening for non-viral, non-invasive, and targeted gene delivery[J].Journal of Controlled Release, 2015, 212 (10) :1-9.
[33]	[33]CHEN H, KONOFAGOU E E.The size of blood-brain barrier opening induced by focused ultrasound is dictated by the acoustic pressure[J].J Cereb Blood Flow Metab, 2014, 34 (7) :1197-1204.
[34]	[34]LEINENGA G, GOTZ J.Scanning ultrasound removes amyloid-βand restores memory in an Alzheimer’s disease mouse model[J].Sci Transl Med, 2015, 7 (278) :278ra233.
[35]	[35]ARVANITIS C D, LIVINGSTONE M S, VYKHODTSEVA N, et al.Controlled ultrasound-induced blood-brain barrier disruption using passive acoustic emissions monitoring[J].Plos One, 2012, 7 (9) :4578.
[36]	[36]YUEXI HUANG, RYAN ALKINS, MICHAEL L, et al.Opening the blood-brain barrier with MR imaging-guided focused ultrasound:Preclinical testing on a trans-human skull porcine model[J].Radiology, 2017, 282 (1) :123-130.

Relative Articles(20)

Relative Articles

[1]	Xinbang WANG, An HU, Xipeng ZHAO, Yan WANG, Wei DING, Lipeng CAO, Yu GU, Ke XU, Yunfeng ZHANG. Effect of Ommaya Capsule on Cerebral Hemorrhage Complicated with Acute Hydrocephalus and its Effect on Blood-brain Barrier Function. Journal of Kunming Medical University, 2024, 45(10): 96-104. doi: 10.12259/j.issn.2095-610X.S20241015
[2]	Yuansen LI, Cheng CHEN, Yan TIAN, Ruo SHU, Yu XU, Yuanhua LI. Study on Serum Markers of Intestinal Barrier Damage in Heroin Addicts at Different Withdrawal Times. Journal of Kunming Medical University, 2023, 44(7): 94-99. doi: 10.12259/j.issn.2095-610X.S20230709
[3]	Yun-yan LAN, Yu-ran FENG, Yu ZHENG, Zhen-dong YANG, Yi ZHAO, Mei ZHU. Effectiveness of Low Intensity Focused Ultrasound Stimulation of Nucleus Accumbens in Mice. Journal of Kunming Medical University, 2021, 42(7): 13-19. doi: 10.12259/j.issn.2095-610X.S20210703
[4]	Yuan YANG, Hong-min LIANG, Gui-min ZHU, Han-ning YANG, Wei-han CAO, Yong-ping LU. Application of Ultrasound-Targeted Microbubble Destruction with IL-6 Monoclonal Antibody in Rabbit Myocardial Ischemia-Reperfusion Injury. Journal of Kunming Medical University, 2021, 42(2): 6-12. doi: 10.12259/j.issn.2095-610X.S20210222
[5]	Yu Xiao Dong , Long Jiang . . Journal of Kunming Medical University, 2019, 40(09): 68-71.
[6]	Zhang Liu Ying , Wang Jie Qiong , Lin Ai Jin , Liu Zheng , Chen Mo Xian , Ao Li Juan . . Journal of Kunming Medical University, 2019, 40(01): 44-47.
[7]	Yang Meng Chang , Deng Xiao Fan , Li Peng , Su Wen Jie , Jiang Rong , Wen Kai Lan , Xie Min . Application of Enhanced Recovery After Surgery in Complicated Hepatic Alveolar Echinocoecosis Surgery. Journal of Kunming Medical University, 2018, 39(03): 103-108.
[8]	Li Yong , Cao Qing , Li Lan , Yang Chun , Yang Yan , Zhou Xue Juan , Chen Ting . . Journal of Kunming Medical University, 2017, 38(05): 101-104.
[9]	Dong Ming Chun . The Clinical Effect of Ultrasound Guided Minimally Invasive Rotary Cutting on Breast Benign Lesions. Journal of Kunming Medical University,
[10]	Liu Shao Xing . Effect of Parecoxib Sodium Pretreatment on Permeability of Blood-Brain Barrier in a Rat Model of Focal Cerebral Ischemia-reperfusion Injury. Journal of Kunming Medical University,
[11]	Yang Yang . Optimizing Preparation of Biotin-microbubbles of Ultrasound. Journal of Kunming Medical University,
[12]	Zeng Bai Rui . . Journal of Kunming Medical University,
[13]	Liu Zhi Heng . . Journal of Kunming Medical University,
[14]	Dai Mei . . Journal of Kunming Medical University,
[15]	Jiang Hong . . Journal of Kunming Medical University,
[16]	Hu Xiao . . Journal of Kunming Medical University,
[17]	Guo Feng . . Journal of Kunming Medical University,
[18]	Ge Yu Ming . . Journal of Kunming Medical University,
[19]	. Value of Contrast-enhanced Ultrasound in Diagnosis of Prostate Cancer. Journal of Kunming Medical University,
[20]	Yuan Hui . . Journal of Kunming Medical University,