Diagnostic Value of Relative Volume of Ground Glass Opacities in Lungs Injury by 320-row CT in Paraquat Intoxication

Sun Rong Qing; Xiang Shu Tian; Su Yun Shan; Yue Li Rong; He Xi; Peng Cong

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Sun Rong Qing , Xiang Shu Tian , Su Yun Shan , Yue Li Rong , He Xi , Peng Cong . Diagnostic Value of Relative Volume of Ground Glass Opacities in Lungs Injury by 320-row CT in Paraquat Intoxication[J]. Journal of Kunming Medical University, 2018, 39(07): 15-19.

Citation:

Sun Rong Qing , Xiang Shu Tian , Su Yun Shan , Yue Li Rong , He Xi , Peng Cong . Diagnostic Value of Relative Volume of Ground Glass Opacities in Lungs Injury by 320-row CT in Paraquat Intoxication[J]. Journal of Kunming Medical University, 2018, 39(07): 15-19.

Citation:

Sun Rong Qing , Xiang Shu Tian , Su Yun Shan , Yue Li Rong , He Xi , Peng Cong . Diagnostic Value of Relative Volume of Ground Glass Opacities in Lungs Injury by 320-row CT in Paraquat Intoxication[J]. Journal of Kunming Medical University, 2018, 39(07): 15-19.

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Diagnostic Value of Relative Volume of Ground Glass Opacities in Lungs Injury by 320-row CT in Paraquat Intoxication

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基金：昆明医科大学研究生创新基金资助项目 (2017S145);

Received Date: 2018-02-04

Abstract

Abstract

Objective To assess the diagnostic value of the relative volume of ground glass opacities (GGO) in lungs injury by 320-row CT in paraquat intoxication.Methods A total of 48 healthy rabbits were randomly divided into four groups: one control group and three experimental groups by gavage treating with the concentration of25, 35, 45 mg/kg paraquat and equal dose of physiological saline.320-row CT examination were performed on the1 st, 7 th, 14 th and 28 th day after poisoning. Semi-quantitative analysis of the relative volume of GGO was conducted. One rabbit from each group were randomly sacrificed to obtain the lung tissue for pathological examinations at each time point.Re s ults Compared with the control group, the relative volumes of GGO in the three experimental groups were significantly greater than that in the control group at each time point (P <0.05) .Significant dose-dependence at different drug concentrationsin in the three experimental groups were found througy multiple comparison (P<0.05) . The relative volume of GGO increased with the increasing of drug dose. The lung tissues of poisoned rabbits under light microscope showed different degrees of inflammatory cell infiltration, focal hyperemia, widened alveolar septum, alveolar collapse, and partial alveolar cavity occlusion, and all the above pathological changes worsened with time.Conclus ion 320 row CT determination of relative volume of GGO can better quantify the paraquat-induced lung injury, which can provide an objective basis for clinical evaluation.
- 320-row CT,
- Paraquat,
- Lung injury,
- Ground glass opacities,
- Relative volume

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References(11)

References

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