Effect of Statins on Lower Airway Bacterial Colonization in Elderly Patients with Stable Chronic Obstructive Pulmonary Disease of Different Severity

Meng Hong Qiong; Su Hui Peng; Long Qiong Hua; Wang Ting Ting; Hu Yang

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Meng Hong Qiong , Su Hui Peng , Long Qiong Hua , Wang Ting Ting , Hu Yang . Effect of Statins on Lower Airway Bacterial Colonization in Elderly Patients with Stable Chronic Obstructive Pulmonary Disease of Different Severity[J]. Journal of Kunming Medical University, 2018, 39(07): 61-66.

Citation:

Meng Hong Qiong , Su Hui Peng , Long Qiong Hua , Wang Ting Ting , Hu Yang . Effect of Statins on Lower Airway Bacterial Colonization in Elderly Patients with Stable Chronic Obstructive Pulmonary Disease of Different Severity[J]. Journal of Kunming Medical University, 2018, 39(07): 61-66.

Citation:

Meng Hong Qiong , Su Hui Peng , Long Qiong Hua , Wang Ting Ting , Hu Yang . Effect of Statins on Lower Airway Bacterial Colonization in Elderly Patients with Stable Chronic Obstructive Pulmonary Disease of Different Severity[J]. Journal of Kunming Medical University, 2018, 39(07): 61-66.

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Effect of Statins on Lower Airway Bacterial Colonization in Elderly Patients with Stable Chronic Obstructive Pulmonary Disease of Different Severity

Funds:

基金：云南省教育厅科学研究基金资助项目 (2014Y164);

Received Date: 2018-02-09

Abstract

Abstract

Objective To explore the effect of statins on lower airway bacterial colonization (LABC) in elderly patients with stable chronic obstructive pulmonary disease (COPD) of different severity by analyzing the bacteriological changes of LABC in those patients and its relationship with acute exacerbation, inflammatory reaction and lung function impairment.Methods A total of 96 patients with stable COPD were enrolled and quantitative and qualitative bacteriological analysis of patients' sputum and bronchoalveolar lavage fluid (BALF) were performed.According to the test results, patients were divided into four groups: patients with LABC positive receiving statin treatment, patients with LABC positive receiving conventional therapy, patients with LABC negative receiving statin treatment, and patients with LABC negative receiving conventional therapy.The serum levels of IL-6, IL-8, hs-CRP, TNF-α and lung function were examined before and after the experiment.Results There were 40 patients with LABC positive in 96 patients, with bacterial colonization rate of 45.98%.The serum level of IL-6, IL-8, TNF-α and hs-CRP in patients with LABC positive were significantly higher than those in patients with LABC negative (P <0.05) .Lung function in patients with LABC positive was significantly poorer than that in patients with LABC negative (P <0.05) .One-year follow-up showed that the serum levels of IL-6, IL-8, TNF-α and hs-CRP in patients with statin treatment were significantly lower than those in patients with conventional therapy (P<0.05) and better improvements of lung function were observed in patients with statin treatment (P>0.05) .The risk of acute exacerbation in patients with statin treatment was significantly higher than those in patients with conventional treatment (P<0.05) .The bacteria engraftment rate of the patients with LABC positive receiving statin treatment was significantly higher than that in patients with conventional therapy (P<0.05) while it was lower in the patients with LABC negative receiving statin treatment.Conclusion The levels of IL-6, IL-8, TNF-α, hs-CRP in elderly patients with stable COPD and LABC positive are higher than those with LABC negative.Treatment combined with statins helps to inhibit LABC or proliferation, reduce inflammatory reaction and acute exacerbation, delay the decline of lung function, and improve clinical symptoms.
- Elderly stable COPD,
- Lower airway bacterial colonization,
- Statins,
- Inflammatory factor,
- Lung function

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References(13)

References

[1]	[1]ZALACAIN R, SOBMDILLO V, AMILIBI8 J, et a1.Predisposing factors to bacterial colonization in chro Ilic obstructive pu Imonary disease[J].Eur Respir J, 1999, 13 (1) :343-348.
[2]	[2]MONSO E, ROSEU A, BONET G, et al.Risk factors for lower airway bacterial colonization in chronic bronchitis[J].Eur Respir J, 1999, 13 (1) :338-342.
[3]	[3]SANJAY SETHI, TIMOTHY F.Murphy.Bacterial infection in chronic obstructive plumonary disease in2000:a state-of-the-art review[J].Clinic Microbiology Reviews, 2001, 14 (2) :336-363.
[4] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组畅中华医学会呼吸分会慢性阻塞性肺疾病诊治指南 (2013年修订版) [J].中华结核和呼吸杂志, 2013, 36 (4) :255-264.
[5]	[5]SOLER N.EWIG S, TORRES A, et al.Airwayinnammation and bronchial microbia I pattems in patients with stable chronic obstl、Jctive pulmonary disease[J].Eur Respir J, 2001, 14 (3) :1015-1022.
[6]	[6]LOUKIDES S, BARTZIOKAS K, VESTBO J, etal.Novel anti-inflammatory agents in COPD:targeting lungand systemic inflammation[J].Curr Drug Targets, 2013, 14 (26) :235-245.
[7]	[7]KIM D Y.RYU S Y, LIM J E, et a1.Anti inflammatory mechanism of simvastatin in mouse allergic asthma model[J].Eur J Pharmacol, 2007, 557 (7) :76-86.
[8]	[8]SOYSETH V, BREKKE PH, SMITH P, et al.Statin use is associated with reduced.mortality in COPD[J].Eur Respir J, 2007, 29 (2) :279-283.
[9]KEDDISSI儿, YOUNIS WG, CHBEIR EA, et a1.The use of statins and lung function incurrent and former smokers[J].Chest, 2007, 13 (2) :1764-1767.
[10]	[10]ALEXEEFF S E.LITONJUA A A, SPARROW D, et al.Statin UM reduces decline in lung function:VA normative aging study[J].Am J Respir Ctit Care Med, 2007, 176 (1) :742-747.
[11]	[11]WRIGHT J L, ZHOU S, PREOBRAZHENSKA O, et al.Statin reverses smoke-induced pulmonary hypertension and prevents emphysema but not airway remodeling[J].Am J Respir Care Med, 2011, 183 (6) :50-58.
[12]	[12]LAHOUSSEL, LOTH DW, JOOS GF, et al.Statins, systemic inflammation and risk of death in COPD:the otterdam study[J].Pulm Pharmacol&The rapeutics, 2013, 26 (2) :212-217.
[13]	[13]CRINER GJ, CONNETT JE, AARON SD, etal.Simvastatin for the preventiong of exacerbations in moderate-to-severe COPD[J].N Engl J Med, 2014, 370 (23) :2201-2210.

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