Effects of Geraniin on Modulating the Expression of Cbfα 1 Gene in Rabbit Osteoporotic Fracture

Zhang Xiao Chao; Yang Ren Hua; Shen Ying; He Hong Yan; Zhong Jin Ping; Shen Zhi Qiang; Chen Peng

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Zhang Xiao Chao , Yang Ren Hua , Shen Ying , He Hong Yan , Zhong Jin Ping , Shen Zhi Qiang , Chen Peng . Effects of Geraniin on Modulating the Expression of Cbfα 1 Gene in Rabbit Osteoporotic Fracture[J]. Journal of Kunming Medical University, 2018, 39(08): 1-4.

Citation:

Zhang Xiao Chao , Yang Ren Hua , Shen Ying , He Hong Yan , Zhong Jin Ping , Shen Zhi Qiang , Chen Peng . Effects of Geraniin on Modulating the Expression of Cbfα 1 Gene in Rabbit Osteoporotic Fracture[J]. Journal of Kunming Medical University, 2018, 39(08): 1-4.

Citation:

Zhang Xiao Chao , Yang Ren Hua , Shen Ying , He Hong Yan , Zhong Jin Ping , Shen Zhi Qiang , Chen Peng . Effects of Geraniin on Modulating the Expression of Cbfα 1 Gene in Rabbit Osteoporotic Fracture[J]. Journal of Kunming Medical University, 2018, 39(08): 1-4.

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Effects of Geraniin on Modulating the Expression of Cbfα 1 Gene in Rabbit Osteoporotic Fracture

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基金：国家自然科学基金资助项目 (81660613, 81260493, 81160401); 云南省社会发展计划重点基金资助项目 (2015FA021); 云南省应用基础研究计划基金资助项目 (2017FB139); 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2013FB103, [2017FE467 (-021) ]; 云南省教育厅科学研究基金资助项目 (2015Y154);

Received Date: 2018-05-21

Abstract

Abstract

Objective To investigate the the effects of geraniin on modulating the mRNA expression of corebinding factor α 1 (Cbfα 1) . Methods The m RNA expressions of Cbfα 1 were detected by real time fluorescence quantitative PCR. Results As compared with the sham group, the expressions of Cbfα 1 mRNA were markedly suppressed in the model group, 12 and 24 w after OPF (P < 0.05) . Compared with the model group, geraniin significantly increased mRNA expressions of Cbfα 1. Conclusion Geraniin can upregulate Cbfα 1 gene expression and improve the treatment for OPF.
- Geraniin,
- Osteoporotic fracture,
- Corebinding factor α 1

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References(16)

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