Clinical Significance of Serum Vitamin D Levels Change in Patients with Breast Cancer before and after Chemoradiotherapy

Li Ning; Xu Miao; Zhang Wei; Zhang Qing; Kong Ying

Article Contents

Article Navigation > Journal of Kunming Medical University > 2018 > 39(08): 108-112

Li Ning , Xu Miao , Zhang Wei , Zhang Qing , Kong Ying . Clinical Significance of Serum Vitamin D Levels Change in Patients with Breast Cancer before and after Chemoradiotherapy[J]. Journal of Kunming Medical University, 2018, 39(08): 108-112.

Citation:

Li Ning , Xu Miao , Zhang Wei , Zhang Qing , Kong Ying . Clinical Significance of Serum Vitamin D Levels Change in Patients with Breast Cancer before and after Chemoradiotherapy[J]. Journal of Kunming Medical University, 2018, 39(08): 108-112.

Citation:

Li Ning , Xu Miao , Zhang Wei , Zhang Qing , Kong Ying . Clinical Significance of Serum Vitamin D Levels Change in Patients with Breast Cancer before and after Chemoradiotherapy[J]. Journal of Kunming Medical University, 2018, 39(08): 108-112.

PDF( 210 KB)

Clinical Significance of Serum Vitamin D Levels Change in Patients with Breast Cancer before and after Chemoradiotherapy

Funds:

基金：陕西省自然基础研究计划基金资助项目 (2015JM8427);

Received Date: 2018-03-12

Abstract

Abstract

Objective To investigate the clinical significance of serum vitamin D levels change in patients with breast cancer (BC) before and after radiotherapy and chemotherapy.Methods A total of 100 BC patients and 100 healthy controls were enrolled in the First Affiliated Hospital of Xi'an Jiaotong University from June 2016 to June 2017. All the patients received adjuvant chemotherapy and radiotherapy after operation. Serum 25-hydroxyvitamin D3 (25-OHD) levels were measured using the DRG ELISA kit.Results There was no significant difference in age, BMI, times of deliveries, hemoglobin level, total lymphocyte count and platelet count between the cases and the controls (P>0.05) . The incidence of vitamin deficiency was 100% in the case group and 85% in the control group. The level of serum vitamin D was (16.63 ± 1.83) ng/ml in the case group before radiotherapy and chemotherapy, and (25.56 ± 6.64) ng/m L in the control group. The level of vitamin D before radiotherapy and chemotherapy in the case group was significantly lower than that of the control group (P< 0.001) . The mean level of vitamin D was (11.35 ± 2.87) ng/m L after radiotherapy and was significantly lower than that before radiotherapy and chemotherapy (P<0.001) . Two different chemotherapy regimens were used in this study, FEC/T and CMF regimens. Before radiotherapy and chemotherapy, there was no significant difference in vitamin D levels between the two groups (P>0.05) . After radiotherapy and chemotherapy, vitamin D levels in both groups were significantly decreased (P<0.001) , but there was no significant difference between the two groups in vitamin D levels (P>0.05) . Multiple regression analysis showed that age, BMI and number of deliveries were significantly correlated with changes of vitamin D levels before and after radiotherapy and chemotherapy (P<0.05) , and correlations were as follows: age, BMI and times of deliveries.Conclusion Vitamin D deficiency may be associated with breast cancer. Patients' age, BMI and times of deliveries were significantly correlated with vitamin D levels before and after radiotherapy and chemotherapy.
- Breast cancer (BC) ,
- Vitamin D,
- Radiotherapy,
- Chemotherapy

FullText(HTML)

References(17)

References

[1]牛四明, 罗欢欢.新辅助化学治疗联合手术治疗局部晚期乳腺癌疗效观察[J].新乡医学院学报, 2017, 34 (5) :429-431.
[2]耿怡, 马富成, 热西达加帕尔, 等.双模态超声在评估乳腺癌新辅助化疗疗效中的应用价值[J].新疆医科大学学报, 2017, 40 (3) :275-278.
[3]	[3]BOEKE C E, TAMIMI R M, BERKEY C S, et al.Adolescent dietary vitamin D and sun exposure in relation to benign breast disease[J].Cancer Causes&Control, 2015, 26 (8) :1-7.
[4]朱玲龑, 冉利梅, 聂四平, 等.677例围绝经期女性维生素D3水平及其影响因素[J].贵州医科大学学报, 2017, 42 (11) :1321-1326.
[5]张莉, 陈健.维生素D缺乏饲料联合高果糖糖水喂养诱导小鼠非酒精性脂肪肝炎[J].兰州大学学报 (医学版) , 2017, 43 (2) :20-27.
[6]	[6]MA Y, YU W D, HERSHBERGER P A, et al.1alpha, 25-Dihydroxyvitamin D3 potentiates cisplatin antitumor activity by p73 induction in a squamous cell carcinoma model[J].Molecular Cancer Therapeutics, 2008, 7 (9) :3047.
[7]刘刚, 马云婷.乳腺数字化摄影检测在平凉地区触诊阴性乳腺癌诊断中的意义[J].国外医学医学地理分册, 2017, 38 (3) :276-278.
[8]	[8]GIOVANNUCCI E.The epidemiology of vitamin D and cancer incidence and mortality:A review (United States) [J].Cancer Causes&Control Ccc, 2005, 16 (2) :83-95.
[9]NESS R A, MILLER D D, LI W.The role of vitamin D in cancer prevention[J].Chinese Journal of Natural Medicines中国天然药物, 2015, 13 (7) :481-497.
[10]	[10]HOLICK M F, BINKLEY N C, BISCHOFFFERRARI H A, et al.Evaluation, treatment, and prevention of vitamin D deficiency:An Endocrine Society clinical practice guideline[J].Journal of Clinical Endocrinology&Metabolism, 1911, 96 (7) :1911.
[11]蒋安然.绝经前后女性维生素D营养状况及其与血脂代谢相关性研究[D].合肥:安徽医科大学硕士论文, 2015.
[12]	[12]RAGAB W S, SALEH W F, TAWFIK L T.Vitamin D deficiency in postmenopausal Egyptian women[J].International Journal of Gynaecology&Obstetrics the Official Organ of the International Federation of Gynaecology&Obstetrics, 2013, 123 (1) :75-76.
[13]	[13]REZA S F, FAEZEH K.The Correlation of Plasma 25-Hydroxyvitamin D deficiency with risk of breast neoplasms:A systematic review[J].Iranian Journal of Cancer Prevention, 2016, 9 (3) :75-76.
[14]	[14]GHAZI M, ROUX C.Hormonal deprivation therapy-induced osteoporosis in postmenopausal women with breast cancer[J].Best Practice&Research Clinical Rheumatology, 2009, 23 (6) :805-811.
[15]	[15]ABBAS S.Dietary vitamin D and calcium intake and premenopausal breast cancer risk in a German case-control study[J].Nutrition&Cancer, 2007, 59 (1) :54-61.
[16]	[16]LIN J, MANSON J A E, LEE I, et al.Intakes of calcium and vitamin D and breast cancer risk in women[J].Archives of Internal Medicine, 2007, 167 (10) :1050-1059.
[17]	[17]KASSI E N, STAVROPOULOS S, KOKKORIS P, et al.Smoking is a significant determinant of low serum vitamin D in young and middle-aged healthy males[J].Hormones, 2015, 14 (2) :245-250.

Relative Articles(20)

Relative Articles

[1]	Jiang ZHANG, Xijuan ZHAO, Jiang WU, Bingkun YANG, Ni YANG, Liping ZHOU. Analysis of Frailty Status and Influencing Factors in Lung Cancer Patients Undergoing Radiotherapy. Journal of Kunming Medical University, 2024, 45(9): 1-8.
[2]	Sixiang LIU, Yongkun HUANG, Shulan SHI, Jingjing SUN, Lisi LUO, Li WANG, Yu LING. Analysis of Vitamin D in Children with Henoch-Schonlein Purpura. Journal of Kunming Medical University, 2024, 45(1): 133-135. doi: 10.12259/j.issn.2095-610X.S20240122
[3]	Nan ZHANG, Yanling YANG, Qingqing WAN, Jiang ZHAO, Min PENG, Xiao ZHU, Zhitao LIU, Qiang ZHANG. Analysis on Nutritional Status of Vitamin D Among Adults of 6 Ethnic Minority Groups Native to Yunnan Province. Journal of Kunming Medical University, 2024, 45(2): 105-111. doi: 10.12259/j.issn.2095-610X.S20240214
[4]	Zheng ZHANG, Yanhong YANG, Zaihui FENG, Lujiang ZHAN, Jinxian PU, Qianting DUAN. Value of High Field Tntensity MRIT1 Perfusion Imaging Combined with DWI Imaging in Evaluating The Efficacy of Neoadjuvant Chemotherapy for Breast Cancer. Journal of Kunming Medical University, 2024, 45(7): 148-153. doi: 10.12259/j.issn.2095-610X.S20240722
[5]	Jiang WU, Jiang ZHANG, Yanyan FEI, Qin LIU, Yuanjiao CHEN, Yuanxiao WANG, Shuifen DAI. Application of Knowledge-attitude-behavior Continuation in Nursing Education for Nasopharyngeal Cancer Patients After Radiotherapy and Chemotherapy. Journal of Kunming Medical University, 2024, 45(10): 166-172. doi: 10.12259/j.issn.2095-610X.S20241026
[6]	Yongyi ZOU, Zhiye QI, Dongmei SUN, Chunmei Wan, Kun LIANG. Effects of Different Vitamin D Doses on Bone Metabolism and Growth and Development Indicators of Preterm infants：A Cohort Study. Journal of Kunming Medical University, 2023, 44(11): 76-81. doi: 10.12259/j.issn.2095-610X.S20231111
[7]	Jiang WU, Shuifen DAI, Qin LIU, Shoutao YANG, Jiang ZHANG, Jiao YANG, Qiongyao GUAN. Effect of Nutrition Clinical Nursing Pathway for Nasopharyngeal Carcinoma Patients Concurrent Radiotherapy and Chemotherapy. Journal of Kunming Medical University, 2023, 44(5): 185-190. doi: 10.12259/j.issn.2095-610X.S20230510
[8]	Tong XU, Yantuanjin MA, Yuhang ZHANG, Qiuyue HE, Wei HUANG, Mengxin LU, Jian TANG, Jianping HE, Guoqing JIANG, Yuan QIAN. Second-generation Sequencing Study of Trophoblast Cells in vitro Stimulated by Different Concentrations of Vitamin D. Journal of Kunming Medical University, 2022, 43(10): 1-9. doi: 10.12259/j.issn.2095-610X.S20221021
[9]	Chen WANG, Sha LI, Boxue ZHANG, Jinhua HE. Effect of VitD Supplementation on the Improvement of Autoimmune Thyroiditis in Childbearing Age Females. Journal of Kunming Medical University, 2022, 43(9): 135-140. doi: 10.12259/j.issn.2095-610X.S20220907
[10]	Xinyi LI, Yong YUAN, Yan FU, Yan ZHU. Distribution of Vitamin D Levels in Women of Different Ages in Early Pregnancy. Journal of Kunming Medical University, 2022, 43(4): 137-141. doi: 10.12259/j.issn.2095-610X.S20220421
[11]	Yong YUAN, Xinyi LI, Yan FU, Yan ZHU. Analysis of Vitamin D Level in Pregnant Women and Infants in Kunming and Study on the Relationship between Fasting Blood Glucose Level and Vitamin D Level during Pregnancy. Journal of Kunming Medical University, 2022, 43(9): 125-129. doi: 10.12259/j.issn.2095-610X.S20220931
[12]	Jiawei LIAO, Xiaoqing HU, Yi YANG. Changes of Thyroid Function and Its Clinical Significance before and after Radiotherapy and Chemotherapy in Patients Undergoing Radical Breast Cancer Treatment. Journal of Kunming Medical University, 2022, 43(2): 72-77. doi: 10.12259/j.issn.2095-610X.S20220229
[13]	Yan GAO, Xiang-lei TONG, Hao-ran TANG, Li WU. Analysis of Serum Fat-soluble Vitamin Levels in Infants and Children in Anning City. Journal of Kunming Medical University, 2021, 42(4): 44-48. doi: 10.12259/j.issn.2095-610X.S20210408
[14]	Ling-ling YAN, Zhi-hong QIAN, Yue NI, Huang WU. Clinical Investigation of Vitamin D and Calcium Supplement’ Effect on the Occurrence of Cardiovascular and Cerebrovascular Diseases in POP Patients. Journal of Kunming Medical University, 2021, 42(10): 139-144. doi: 10.12259/j.issn.2095-610X.S20211036
[15]	Jiang ZHANG, Yan LIU, Wen-hui LI, Xi-juan ZHAO, Zheng-ting CHEN, Qiong-yao GUAN, Jiang WU. Effects of Pre-sleep Music Therapy on Sleep Quality and Cancer-related Fatigue in Patients with Breast Cancer Undergoing Radiotherapy. Journal of Kunming Medical University, 2020, 41(12): 173-178. doi: 10.12259/j.issn.2095-610X.S20201248
[16]	Li Yan Hong , Zhang Xian , Zhang Jun Tao , Zhao Meng Ru , Tang Jia Hui , Li Lin Xia . . Journal of Kunming Medical University, 2018, 39(11): 67-73.
[17]	Li Chen , Yang Ming Ying , Duan Wen Jing , Jiang Ai Mei , Huang Qi , Yang Xue Fang . A Screening of Pre-chemotherapy Psychological Distress in Breast Cancer Patients and An Analysis of the Influencing Factors. Journal of Kunming Medical University, 2018, 39(08): 33-38.
[18]	Long Xiang Yu . . Journal of Kunming Medical University,
[19]	Li Xiao Yong . . Journal of Kunming Medical University,
[20]	Hu Li Bing . . Journal of Kunming Medical University,