Volume 39 Issue 08
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Article Navigation >  Journal of Kunming Medical University  > 2018  >  39(08): 18-22
Jie AN, Hui LIU, Shuohua CHEN. Effects of Subcutaneous Injection of Quick Acting Insulin Analogues at Different Time Points on Blood Glucose Level and MCP-1 Level in Patients with Hyperglycemic Crisis[J]. Journal of Kunming Medical University, 2022, 43(4): 142-145. doi: 10.12259/j.issn.2095-610X.S20220428
Citation: Ji Juan Juan , Fan Qun , Zhou Zhi , Liu Xiao Jun , Yao Shuang , Li Xu Dong , Yang Shuang, Shen Yong . A Study on the Effects of Occlusal Function on CTGF Expression in Orthodontics[J]. Journal of Kunming Medical University, 2018, 39(08): 18-22.
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A Study on the Effects of Occlusal Function on CTGF Expression in Orthodontics

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基金： 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2015FB077); 云南省牙病防治中心基金资助项目 (2014NS044);

  • Received Date: 2018-02-17
    Abstract
  • Objective To investigate CTGF changes in the expression of the gum tissue before and after orthodontic treatment, and to preliminarily explore the modification mechanism of gingival tissue and the effectiveness of the intervention measures. Methods 72 male Sprague-Dawley rats of 12-week-old, weight about 250 g-300 g, randomly divided into 6 groups: blank control group (A) , healthy teeth orthodontic group (B) , low functional group (C) , low occlusal function teeth orthodontic group (D) , combined intervention group (E) , bite orthodontic intervention group (F) . The results of the study were compared at 1 w, 2 w, 4 w, 6 w.Results (1) HE staining results showed the atrophy of the gingival tissue, which suggested that occlusal hypofunction SD rats model were successfully established. (2) Fluorescence quantitative results of CTGF in gingival tissue: 6 w: group B was higher than group D and group F (P<0.05) . Conclusion (1) the expression of CTGF in the low occlusion group was lower than that of the normal control group with time, and the gum tissue was vulnerable to atrophy. (2) It remains to be further studied whether the bite force recovery is effective.
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    • References(9)
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