A Study on the Effects of Occlusal Function on CTGF Expression in Orthodontics

Ji Juan Juan; Fan Qun; Zhou Zhi; Liu Xiao Jun; Yao Shuang; Li Xu Dong; Yang Shuang; Shen Yong

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Ji Juan Juan , Fan Qun , Zhou Zhi , Liu Xiao Jun , Yao Shuang , Li Xu Dong , Yang Shuang, Shen Yong . A Study on the Effects of Occlusal Function on CTGF Expression in Orthodontics[J]. Journal of Kunming Medical University, 2018, 39(08): 18-22.

Citation:

Ji Juan Juan , Fan Qun , Zhou Zhi , Liu Xiao Jun , Yao Shuang , Li Xu Dong , Yang Shuang, Shen Yong . A Study on the Effects of Occlusal Function on CTGF Expression in Orthodontics[J]. Journal of Kunming Medical University, 2018, 39(08): 18-22.

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A Study on the Effects of Occlusal Function on CTGF Expression in Orthodontics

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2015FB077); 云南省牙病防治中心基金资助项目 (2014NS044);

Received Date: 2018-02-17

Abstract

Abstract

Objective To investigate CTGF changes in the expression of the gum tissue before and after orthodontic treatment, and to preliminarily explore the modification mechanism of gingival tissue and the effectiveness of the intervention measures. Methods 72 male Sprague-Dawley rats of 12-week-old, weight about 250 g-300 g, randomly divided into 6 groups: blank control group (A) , healthy teeth orthodontic group (B) , low functional group (C) , low occlusal function teeth orthodontic group (D) , combined intervention group (E) , bite orthodontic intervention group (F) . The results of the study were compared at 1 w, 2 w, 4 w, 6 w.Results (1) HE staining results showed the atrophy of the gingival tissue, which suggested that occlusal hypofunction SD rats model were successfully established. (2) Fluorescence quantitative results of CTGF in gingival tissue: 6 w: group B was higher than group D and group F (P<0.05) . Conclusion (1) the expression of CTGF in the low occlusion group was lower than that of the normal control group with time, and the gum tissue was vulnerable to atrophy. (2) It remains to be further studied whether the bite force recovery is effective.
- Occlusal hypofunction,
- CTGF,
- Orthodontic treatment,
- Gingival recession

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References(9)

References

[1]	[1]MASAHIDE MOTOKAWA, AKIKO TERAOA, ERSAN I.Karadeniz.Effects of long-term occlusal hypofunction and its recovery on the morphogenesis of molar roots and the periodontium in rats[J].J Angle Orthodontist, 2013, 4 (83) :597-604.
[2]	[2]MIYAGAWA A, CHIBA M, HAYASHI H, IGARASHI K.Compressive force induces VEGF production in periodontal tissues[J].J Dent Res, 2009, 7 (88) :752-756.
[3]	[3]SRINGKARN BORIBOON S, MATSUMOTO Y, SOMA K.Root resorption related to hypofunctional periodontium in experimental tooth movement[J].J Dent Res, 2003, 5 (82) :486-490.
[4]束蓉.临床牙周病治疗学[M].上海:上海世界图书出版社, 2011:25.
[5]	[5]TRACKMAN1 P C, KANTARCI A.Molecular and clinical aspects of drug-induced gingival overgrowth[J].Journal of Dental Research, 2015, 4 (94) :540-546.
[6]	[6]COSSETIN E, JANSON G, DE CARVALHO M G, et al.Influence of low-level laser on bone remodeling during induced tooth movement in rats[J].J Angle Orthodontist, 2013, 6 (83) :1015-1021.
[7]	[7]JASON W, MORRIS A, PHILLIP M, et al.Prevalence of gingival recession after orthodontic tooth movements[J].J American Journal of Orthodontics and Dentofacial Orthopedics, 2017, 5 (151) :854-858.
[8]刘红, 米丛波, 祝军.正畸力作用下大鼠炎性牙周组织中肝细胞生长因子的表达[J].中国组织工程研究, 2014, 18 (15) :2377-2382.
[9]	[9]ELENA ANNABEL, MONICA MIHAELA, MONICA ILEANA, et al.The involvement of TGF-β1 and CTGF in regional gingival overgrowth[J].Rom J Morphol Embryol, 2012, 1 (53) :143-150.

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