A Study on the Influence of Atorvastatin for the CXCL Chemokines and Vascular Endothelial Damage Indexes of Patients with Angina Pectoris of Coronary Heart Disease

Zhao Yi; Yan Zi Jun

Volume 39 Issue 08

Turn off MathJax

Article Contents

Abstract

References

Relative Articles

Article Navigation > Journal of Kunming Medical University > 2018 > 39(08): 59-63

Zhao Yi, Yan Zi Jun . A Study on the Influence of Atorvastatin for the CXCL Chemokines and Vascular Endothelial Damage Indexes of Patients with Angina Pectoris of Coronary Heart Disease[J]. Journal of Kunming Medical University, 2018, 39(08): 59-63.

Citation:

Zhao Yi, Yan Zi Jun . A Study on the Influence of Atorvastatin for the CXCL Chemokines and Vascular Endothelial Damage Indexes of Patients with Angina Pectoris of Coronary Heart Disease[J]. Journal of Kunming Medical University, 2018, 39(08): 59-63.

Citation:

Zhao Yi, Yan Zi Jun . A Study on the Influence of Atorvastatin for the CXCL Chemokines and Vascular Endothelial Damage Indexes of Patients with Angina Pectoris of Coronary Heart Disease[J]. Journal of Kunming Medical University, 2018, 39(08): 59-63.

PDF( 215 KB)

A Study on the Influence of Atorvastatin for the CXCL Chemokines and Vascular Endothelial Damage Indexes of Patients with Angina Pectoris of Coronary Heart Disease

Zhao Yi,
Yan Zi Jun

Funds:

基金：四川省科学技术研究与发展计划基金资助项目 (MSD2017003);

Received Date: 2018-04-21

Abstract

Abstract

Objective To study and observe the influence of atorvastatin for the CXCL chemokines and vascular endothelial damage indexes of patients with angina pectoris of coronary heart disease.Methods 86 patients with angina pectoris of coronary heart disease in our hospital from February 2016 to July 2017 were selected as the study objects, and all the patients were divided into the control group and the observation group with 43 cases in each group according to the random number table.The control group were treated with simvastatin on the basis of routine treatment, and the observation group were treated with atorvastatin on the basis of routine treatment.Then the treatment effect of angina pectoris, adverse reaction rates, CXCL chemokines and vascular endothelial damage indexes before and after the treatment of two groups were analyzed and compared.Results The total effective rate of observation group with angina pectoris was significantly higher than that of control group, so the difference had statistical significance (P<0.05) , the adverse reaction rates of two groups were compared, so the difference had no statistical significance (P>0.05) , the CXCL chemokines and vascular endothelial damage indexes of two groups before the treatment were compared, and the differenceshad no statistical significance (P>0.05) , the serum PGI2 of observation group after the treatment were lower than those of control group, the serum CXCL chemokines and other vascular endothelial damage indexes were lower than those of control group, and the differences had statistical significance (P<0.05) . Conclusions The treatment effect of atorvastatin in the patients with angina pectoris of coronary heart disease is better, and its safety is higher, and it has a better improvement role for the CXCL chemokines and vascular endothelial damage indexes, so it has a higher application value in the patients with angina pectoris of coronary heart disease.
- Torvastatin,
- Angina pectoris of coronary heart disease,
- CXCL chemokines,
- Vascular endothelial damage indexes

FullText(HTML)

References(21)

References

[1]王俊霞.阿托伐他汀联合曲美他嗪治疗冠心病的临床观察[J].中国现代药物应用, 2016, 10 (17) :133-134.
[2]高阿妮.观察阿托伐他汀与曲美他嗪联用治疗冠心病的临床疗效[J].航空航天医学杂志, 2016, 27 (4) :483-484.
[3]胡大一.冠心病诊断与治疗研究进展[J].中华心血管病杂志, 2003, 31 (11) :806-811.
[4]钟雨霞.阿托伐他汀钙联合曲美他嗪治疗冠心病的有效性及安全性观察[J].医学理论与实践, 2016, 29 (13) :1719-1720.
[5]贾智, 唐金国, 廖礼强.阿托伐他汀对冠心病患者心室重塑及其相关血清指标的影响[J].西部医学, 2015, 27 (3) :403-404.
[6]李林贵.瑞舒伐他汀与阿托伐他汀对冠心病患者血hs-CRP、Hcy及IMT的影响比较[J].心脑血管病防治, 2015, 15 (5) :409-410.
[7]	[7]CAROSELLI C, DE ROSA R, TANZI P, et al.Endothelial immunomediated reactivity in acute cardiac ischaemia:Role of endothelin 1, interleukin 8 and NT-pro BNP in patients affected by unstable angina pectoris[J].Int J Immunopathol Pharmacol, 2016, 29 (3) :516-522.
[8]袁洪雨.曲美他嗪、阿托伐他汀联合使用对冠心病不稳定型心绞痛的治疗效果观察[J].中西医结合心血管病杂志 (电子版) , 2017, 5 (3) :39.
[9]王桂玲.氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的疗效观察[J].中西医结合心血管病杂志 (电子版) , 2017, 5 (7) :15-16.
[10]王茜, 闵新文, 李东峰, 等.阿托伐他汀对冠心病患者炎症因子和血管内皮功能的疗效[J].心血管康复医学杂志, 2017, 26 (4) :420-424.
[11]	[11]LISOWSKA A, LISOWSKI P, KNAPP M, et al.Serum adiponectin and markers of endothelial dysfunction in stable angina pectoris patients undergoing coronary artery bypass grafting (CABG) [J].Adv Med Sci, 2014, 59 (2) :245-249.
[12]刘颖.阿托伐他汀联合曲美他嗪治疗冠心病80例的临床效果分析[J].中西医结合心血管病杂志 (电子版) , 2016, 4 (25) :65.
[13]马强, 崔国雄.阿托伐他汀联合曲美他嗪对冠心病患者心功能、炎性因子及血管内皮功能的影响[J].实用临床医药杂志, 2016, 20 (23) :5-8.
[14]	[14]KABAKLI A, FRAS Z.Moderate-dose atorvastatin improves arterial endothelial function in patients with angina pectoris and normal coronary angiogram:A pilot study[J].Arch Med Sci, 2017, 3 (4) :827-836.
[15]祝盛善, 王庆春, 胡坚.冠心病不稳定心绞痛治疗前后血清趋化因子CXCL16检测的临床意义[J].临床合理用药杂志, 2015, 8 (8) :88-89.
[16]祝盛善, 胡坚.CXC趋化因子配体16和同型半胱氨酸联合检测在冠心病诊疗中的意义[J].山西医药杂志, 2014, 43 (17) :2088-2090.
[17]卢亚敏, 霍丽静, 张明明, 等.不同类型冠心病合并2型糖尿病患者趋化因子和氧化应激分子水平的研究[J].中国基层医药, 2016, 23 (14) :2107-2110.
[18]陆振涛.瑞舒伐他汀与阿托伐他汀对冠心病急性心肌梗死患者血管内皮功能的影响[J].医药论坛杂志, 2015, 36 (11) :40-42.
[19]	[19]SHEPHERD J, BREAZNA A, DEEDWANIA P C, et al.Relation between change in renal function and cardiovascular outcomes in atorvastatin-treated patients (from the Treating to New Targets[TNT]study) [J].Am J Cardiol, 2016, 117 (8) :1199-1205.
[20]	[20]GUNDAPANENI KK, SHYAMALA N, GALIMUDI RK, et al.A therapeutic effects of atorvastatin on genetic damage in coronary artery disease[J].J Clin Diagn Res, 2016, 10 (6) :28-30.
[21]	[21]WEISS M C, BERGER J S, GIANOS E, et al.Lipoprotein (a) screening in patients with controlled traditional risk factors undergoing percutaneous coronary intervention[J].J Clin Lipidol, 2017, 11 (5) :1177-1180.

Relative Articles(20)

Relative Articles

[1]	Siqi LI, Wenlin TAI. Significance of CXCL10 as a Biomarker of Liver Cirrhosis. Journal of Kunming Medical University, 2022, 43(7): 55-61. doi: 10.12259/j.issn.2095-610X.S20220711
[2]	Jing TANG, Jun-chao HUANG, Ya-fei HUANG, Ming-zhu GENG, Xiao-qin MAO, Jian-ping PU. Application of Lipoprotein-associated Phospholipase A2 in Coronary Heart Disease Patients Taking Statins. Journal of Kunming Medical University, 2021, 42(12): 6-10. doi: 10.12259/j.issn.2095-610X.S20211205
[3]	Sun Xing Yun , Liu Xia , Meng Fan Xing , Wang Le , Wang Feng Li . . Journal of Kunming Medical University, 2020, 41(08): 18-26.
[4]	Dong Dan Hong , Pang Xi Zhuo , Li Lin . . Journal of Kunming Medical University, 2020, 41(08): 27-32.
[5]	Wang Lu , Chen Jie , Kong Wei Long , Yu Ming Li . Biochemical Characteristics of Liver Injury Induced by Atorvastatin Combined HRZ. Journal of Kunming Medical University, 2018, 39(03): 42-48.
[6]	Li Fan, Tong Zong Wu , Yang Chong Meng , Li Juan Juan , Yuan Yun , Wu Chun Yun . . Journal of Kunming Medical University, 2017, 38(05): 16-20.
[7]	Fu Zhong Yang , Yi Jing . Clinical Observation of Treatment of Hypertension and Coronary Heart Disease with Amlodipine Atorvastatin Calcium Tablet. Journal of Kunming Medical University, 2017, 38(10): 117-119.
[8]	Zhao Yu . . Journal of Kunming Medical University,
[9]	Zhou Kai Hua . . Journal of Kunming Medical University,
[10]	Qin Min Li . . Journal of Kunming Medical University,
[11]	Yang Ping . . Journal of Kunming Medical University,
[12]	Zhang Ti Ling . . Journal of Kunming Medical University,
[13]	Li Hong Dao . . Journal of Kunming Medical University,
[14]	Fu Zhong Yang . . Journal of Kunming Medical University,
[15]	Li Fu Ping . . Journal of Kunming Medical University,
[16]	Yan Wen Fei . . Journal of Kunming Medical University,
[17]	. Effects of Yunnan Baiyao on the Expression of VEGF during Fracture Healing. Journal of Kunming Medical University,
[18]	. Therapeutic Effect of PAS Combination Therapy on 40 Patients with Atherosclerosis. Journal of Kunming Medical University,
[19]	. Protective Effects of 20(R)-ginsenoside Rg3 against PAF-induced Injury of Human Umbilical Vein Endothelial Cells. Journal of Kunming Medical University,
[20]	. . Journal of Kunming Medical University,

Supplements(0)

Cited By

Cited by

Periodical cited type(6)

1.	刘敏，蔺晓慧. CXC趋化因子在糖尿病视网膜病变中相关性的研究进展. 内蒙古医学杂志. 2024(06): 711-714 .
2.	杨栋梁. 倍他乐克联合阿托伐他汀钙片对冠心病心绞痛患者血流动力学及血脂水平的影响. 现代诊断与治疗. 2023(04): 533-535+563 .
3.	冯莹，韩真. 不同剂量辛伐他汀与阿托伐他汀分别联合曲美他嗪对CHF患者血脂及心功能的影响. 中国基层医药. 2023(08): 1144-1149 .
4.	于艳丽. 酒石酸美托洛尔片联合辛伐他汀片对冠心病心绞痛患者炎性因子水平的影响. 吉林医学. 2021(06): 1428-1429 .
5.	周淑妮，于颖. 清心解瘀方治疗冠心病心绞痛疗效观察及对患者心功能、CXC型趋化因子和外周血单核细胞Toll样受体/髓样分化因子88/核转录因子κB信号通路的影响. 河北中医. 2020(06): 853-857+861 .
6.	晏子俊，张良明，徐关丽，陈彦清，张月辉，徐文豪，袁晓燕，徐兴梦. 依折麦布联合氟伐他汀对动脉粥样硬化性脑梗死患者血脂四项及Apo-B、hs-CRP水平的影响. 中国医药导刊. 2019(11): 669-673 .