The Curative Effect of Auxiliary Hepatic Arterial Chemoembolization in the Treatment of Microvascular Invasion of Hepatocellular Carcinoma

Tian Bo Yan; Yang Qin Ling; Zhang Jiao Qiong; Han Na; Liu Shao Hua

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Tian Bo Yan , Yang Qin Ling , Zhang Jiao Qiong , Han Na , Liu Shao Hua . The Curative Effect of Auxiliary Hepatic Arterial Chemoembolization in the Treatment of Microvascular Invasion of Hepatocellular Carcinoma[J]. Journal of Kunming Medical University, 2018, 39(08): 86-92.

Citation:

Tian Bo Yan , Yang Qin Ling , Zhang Jiao Qiong , Han Na , Liu Shao Hua . The Curative Effect of Auxiliary Hepatic Arterial Chemoembolization in the Treatment of Microvascular Invasion of Hepatocellular Carcinoma[J]. Journal of Kunming Medical University, 2018, 39(08): 86-92.

Citation:

Tian Bo Yan , Yang Qin Ling , Zhang Jiao Qiong , Han Na , Liu Shao Hua . The Curative Effect of Auxiliary Hepatic Arterial Chemoembolization in the Treatment of Microvascular Invasion of Hepatocellular Carcinoma[J]. Journal of Kunming Medical University, 2018, 39(08): 86-92.

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The Curative Effect of Auxiliary Hepatic Arterial Chemoembolization in the Treatment of Microvascular Invasion of Hepatocellular Carcinoma

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基金：陕西省自然科学基金资助项目 (2017JM8019);

Received Date: 2018-02-21

Abstract

Abstract

Objective To investigate the recurrence rate, the efficacy and safety of auxiliary hepatic arterial chemoembolization after the treatment of microvascular invasion (MIV) of hepatocellular carcinoma. Methods A total of 104 patients with hepatocellular carcinoma clinical staging of early metaphase were collected from the First Affiliated Hospital of Xi'an Jiaotong University in Jan.2010 to Dec.2016, all treated with liver resection and follow-ups. Adopting the method of retrospective analysis, univariate and multivariate analyses were performed to investigate the risk factors for recurrence-free survival (RFS) and overall survival (OS) . Multiple logistic regression was used to identify the clinicopathological characteristics associated with MVI. The rates of RFS and OS were compared among patients with or without MVI treated with liver resection alone or followed by PA-TACE. Results In HCC patients, the gender HBs Ag, total bilirubin, and prothrombin time, AFP, HBV-DNA, the size of largest tumor, capsule, operation type, hepatic door block, Child-Pugh grade, classification comparison differences had no statistical significance between the two groups of with or without TACE (P>0.05) ; Age, nodules, tumor cell resection, and BCLC were statistically significant in the non-MIV infiltration group (P<0.05) .Hypersplenism and recurrence rate were statistically significant in MIV group (P<0.05) .Univariate and multivariate analyses demonstrated that AFP (> 400 ng/m L) , tumor diameter, membrane integrity, MVI, and most liver resection were significantly associated with overall survival rates (P<0.05) , the AFP (>400 ng/m L) , Child-Pugh, grade B, tumor diameter, hepatocellular carcinoma (HCC) and other abnormal degree, membrane integrity, MVI have significant correlation with disease-free survival rate (P<0.05) . Multiple logistic regression identified serum AFP level > 400 ng/L, tumor size > 5 cm, and incomplete tumor envelope was independent correlation factor (P>0.05) . In the HCC patients with MIV, both OS and DFS were significantly improved in patients who received PA-TACE as compared to those who underwent liver resection alone (P> 0.05) , but no significant effect in HCC patients wieh no MIV invasion (P> 0.05) .Conclusions There is a certain correlation between microvascular infiltration and the recurrence rate and survival rate of hepatocellular carcinoma, and the method of using adjuvant hepatic arterial chemoembolization is helpful to reduce the recurrence rate and prolong the survival period.
- Hepatocellular carcinoma,
- Transcatheter arterial chemoembolization,
- Microvascular invasion,
- Efficacy

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References(21)

References

[1]	[1] MCGUIRE S.World Cancer Report 2014.Geneva, Switzerland:World Health Organization, International Agency for Research on Cancer, WHO Press, 2015[J].Adv Nutr, 2016, 7 (2) :418-419.
[2]王宁, 陈腾祥, 刘振华, 等.Calpain-1及Calpain-2在不同迁移能力肝癌细胞系中的表达[J].贵州医科大学学报, 2016, 58 (06) :649-652.
[3]	[3]ELSEGOOD C L, TIRNITZ-PARKER J E, OLYNYK J K, et al.Immune checkpoint inhibition:prospects for prevention and therapy of hepatocellular carcinoma[J].Clin Transl Immunology, 2017, 6 (11) :e161.
[4]龙云铸, 李丹, 谭英征, 等.恩替卡韦联合水飞蓟宾葡甲胺片在乙肝相关性肝癌术后治疗的临床研究[J].新疆医科大学学报, 2017, 40 (01) :35-37.
[5]王晶晶, 刘伟华, 李丹, 等.砷剂治疗消化系统恶性肿瘤的临床进展[J].国外医学 (医学地理分册) , 2016, 37 (01) :40-43.
[6]	[6]YE J Z, CHEN J Z, LI Z H, et al.Efficacy of postoperative adjuvant transcatheter arterial chemoembolization in hepatocellular carcinoma patients with microvascular invasion[J].World J Gastroenterol, 2017, 23 (41) :7415-7424.
[7]	[7]HUO T I, LIU P H, HSU C Y.Detecting microvascular invasion in HCC with contrast-enhanced MRI:Is it a good idea[J].J Hepatol, 2017, 6 (34) :398-401.
[8]	[8]IMURA S, TERAOKU H, YOSHIKAWA M, et al.Potential predictive factors for microvascular invasion in hepatocellular carcinoma classified within the Milan criteria[J].Int J Clin Oncol, 2017, 97 (55) :56-64.
[9]	[9]ZHENG J, SEIER K, GONEN M, et al.Utility of Serum Inflammatory Markers for Predicting Microvascular Invasion and Survival for Patients with Hepatocellular Carcinoma[J].Ann Surg Oncol, 2017, 24 (12) :3706-3714.
[10]戴峰, 朱西琪.索拉非尼在中晚期肝细胞肝癌治疗中的临床价值[J].东南大学学报 (医学版) , 2016, 37 (01) :106-108.
[11]陈洁, 黎乐群.术前预测肝细胞癌并微血管侵犯的研究进展[J].中国普通外科杂志, 2017, 26 (07) :921-925.
[12]段婷, 黄子星, 宋彬.磁共振评价肝细胞癌微血管侵犯的研究进展[J].中国普外基础与临床杂志, 2017, 1 (07) :880-884.
[13]陈炜.经动脉免疫化疗栓塞对肝癌患者免疫功能及血清肿瘤标志物水平的影响[J].新乡医学院学报, 2016, 33 (04) :315-317.
[14]	[14]POTE N, CAUCHY F, ALBUQUERQUE M, et al.Contribution of virtual biopsy to the screening of microvascular invasion in hepatocellular carcinoma:A pilot study[J].Liver Int, 2017, 20 (1) :215-217.
[15]张杰, 段伯焕, 朱功兵.肝细胞癌患者外科手术根治术后生存分析[J].实用肝脏病杂志, 2017, 20 (01) :93-96.
[16]赵盛, 苏刚, 杨文柯, 等.不同临床分期肝细胞肝癌的蛋白质组学研究进展[J].兰州大学学报 (医学版) , 2016, 42 (1) :66-71.
[17]	[17]DAI K, HUANG Y, CHEN Z, et al.Kbtbd2 inhibits the cytotoxic activity of immortalized NK cells through down-regulating m TOR signaling in a mouse hepatocellular carcinoma model[J].Eur J Immunol, 2018, 4 (56) :932-937.
[18]	[18]LI S, LI X, XU A, et al.Screening and clinical evaluation of dominant peptides of centromere protein F antigen for early diagnosis of hepatocellular carcinoma[J].Mol Med Rep, 2018, 17 (3) :14-19.
[19]	[19]XING M, KOKABI N, CAMACHO J C, et al.Prospective longitudinal quality of life and survival outcomes in patients with advanced infiltrative hepatocellular carcinoma and portal vein thrombosis treated with Yttrium-90 radioembolization[J].BMC Cancer, 2018, 18 (1) :75.
[20]	[20]HUBER A R, GONZALEZ R S, ORLOFF M S, et al.Accuracy of vascular invasion reporting in hepatocellular carcinoma before and after implementation of subspecialty surgical pathology sign-out[J].Indian J Pathol Microbiol, 2017, 60 (4) :501-504.
[21]	[21]YUAN G, ZENG CL, ZHU DD, et al.Influences of RFA combined with TACE on the HIF-1alpha and EGR level of patients with primary hepatic carcinoma[J].Eur Rev Med Pharmacol Sci, 2017, 21 (8) :1738-1745.

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