Changes of Cellular Immune Function in Chronic Obstructive Pulmonary Disease Patients with Infection

Zhao Xiao Li; Tang Shu Rong; Wang Si Chen; Qian Jing; Ren Bao Jun; Zeng Wen; Hu Da Chun

Volume 40 Issue 03

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Article Navigation > Journal of Kunming Medical University > 2019 > 40(03): 49-52

Quanyue JI, Mengjing HAN, Kun XU, Tianyun LIU, Hongling SHI, Meng HUANG. Application Value of Nutritional Risk Screening 2002 in Elderly COPD Patients with Dysphagia[J]. Journal of Kunming Medical University, 2023, 44(8): 123-127. doi: 10.12259/j.issn.2095-610X.S20230815

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Zhao Xiao Li , Tang Shu Rong , Wang Si Chen , Qian Jing , Ren Bao Jun , Zeng Wen , Hu Da Chun . Changes of Cellular Immune Function in Chronic Obstructive Pulmonary Disease Patients with Infection[J]. Journal of Kunming Medical University, 2019, 40(03): 49-52.

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Changes of Cellular Immune Function in Chronic Obstructive Pulmonary Disease Patients with Infection

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2017FE468 (-098) ];

Received Date: 2018-11-12

Abstract

Abstract

Objective To explore the changes of cellular immune function in chronic obstructive pulmonary disease patients with infection, and to provide a theoretical basis for COPD patients. Methods Totally 80 patients with COPD complicating infection treated in our hospital from January 2016 to April 2017 were selected as the observation group, contemporaneous 64 patients with simple COPD were selected as the COPD group and 60 healthy people as the control group. The indexes of cellular immunity functions were analyzed in 3 groups. Results (1) In COPD infection group, the average percentage of peripheral blood NK was 19.86 + 10.67, and lower than the COPD group (26.47±10.05) , the difference was statistically significant (P < 0.01) , higher than that of the control group (16.89±5.07) , but the difference was not statistically significant (P > 0.05) . (2) CD3+ cells in peripheral blood of COPD patients with bacterial infection group, COPD group and healthy control group (total T lymphocyte percentage) were (66.64±11.03) , (64.6±11.45) and (67.06±5.55) , there was no significant difference between the three groups (P > 0.05) . (3) In COPD infection group, the peripheral blood CD4 cells and CD4/CD8 ratio were (40.47±10.44) and 1.82 (1.78, 2.57) , higher than the healthy control group[35.01 +7.16 and 1.19 (0.96, 1.66) ], the level of CD8 cells was (23.6±9.82) , lower than the healthy control group (27.50±5.85) , the differences were statistically significant (P < 0.01) ;and COPD group level[ (39.89±9.92) , 2.02 (1.44, 2.83) ] and (21.12±7.64) , there were no statistically significant difference. Conclusions In patients with COPD, the adjuvant immune cell levels are increased but the specific killing immune cells are decreased, on this basis, increased levels of nonspecific killing immune cells help fight infection, immune regulation therapy for COPD patients should focus on improving the level of destruction of immune cells.
- COPD,
- Infection,
- Cellular immune

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[1]余志辉, 林涛.慢性阻塞性肺疾病患者T淋巴细胞及细胞因子的表达与分析[J].中国现代药物应用, 2015, 9 (8) :17-18.
[2]	[2] VOGELMEIER C F, CRINER G J, MARTINEZ F J, et al.Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report.GOLD executive summary[J].Am J Respir Crit Care Med, 2017, 195 (5) :557-582.
[3] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组·慢性阻塞性肺疾病诊治指南 (2013年修订版) [J].中华结核和呼吸杂志, 2013, 36 (4) :255-264.
[4]唐神结.慢性阻塞性肺疾病合并肺结核患者体液核细胞免疫功能的研究[D].苏州:苏州大学临床医学院, 2014.
[5]马爱平, 赵卉, 李建强.慢性阻塞性肺疾病的免疫治疗进展[J].国际呼吸杂志, 2010, 30 (5) :298-302.
[6]	[6]HONG S C, LEE S H.Role of 17 cell and autoimmunity in chronic obstructive pulmonary disease[J].Immune Netw, 2010, 10 (4) :109-114.
[7]	[7]ROVINA N, KOUTSOUKOU A, KOULo URIS N G.Inflammation and immune response in COPD:where do we stand[J].Mediators Inflamm, 2013, 2013 (5) :1-9.
[8]戴百章, 任朝凤, 郑勤玲, 等.慢性阻塞性肺病急性加重患者淋巴细胞组成变化[J].昆明医科大学学报, 2017, 38 (6) :64-67.
[9]孙巍, 杨永辉, 李登瑞, 等.NKT细胞、NK细胞和T细胞亚群在活动性肺结核患者外周血的表达及意义[J].中国免疫学杂志, 2011, 37 (10) :1141-1144.
[10]	[10]XU W H, HU X L, LIU X F, et al. Peripheral Tc17 and Tc17/Interferon-γcells are increased and associated with lung function in patients with chronic obstructive pulmonary disease[J].Chin Med J (Engl) , 2016, 129 (8) :909.
[11]陈立文, 李崇文.不同病程COPD患者免疫功能的临床分析[J].中国实验诊断学, 2017, 21 (1) :32-34.
[12]	[12]SUZUKI M, SZE M A, CAMPBELL J D, et a1.The cellular and molecular determinants of emphysematous destruction in COPD[J].Sci Rep, 2017, 7 (1) :9562.
[13]曾文, 秦雯, 胡大春, 等.慢性阻塞性肺疾病急性加重期患者T细胞免疫机制变化初探[J].重庆医学, 2018, 47 (6) :2298-2302.
[14]李文君, 王淑妮, 田佳, 等.调节性T细胞在COPD发病机制中的作用[J].临床肺科杂志, 2014, 19 (1) :128-130.
[15]韩利红, 张国俊.老年慢性阻塞性肺疾病患者血清细胞因子及细胞免疫的水平及意义[J].中国老年学杂志, 2014, 34 (11) :6065-6066.

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