Qin Jian , Huang Shan , Nie Bo . Clinical Efficacy and Safety of Decitabine in Treatment of 37 Cases of Myelodysplastic Syndrome[J]. Journal of Kunming Medical University, 2017, 38(10): 112-116.
Citation: Zhao Xiao Li , Tang Shu Rong , Wang Si Chen , Qian Jing , Ren Bao Jun , Zeng Wen , Hu Da Chun . Changes of Cellular Immune Function in Chronic Obstructive Pulmonary Disease Patients with Infection[J]. Journal of Kunming Medical University, 2019, 40(03): 49-52.

Changes of Cellular Immune Function in Chronic Obstructive Pulmonary Disease Patients with Infection

Funds:

基金: 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2017FE468 (-098) ];

  • Received Date: 2018-11-12
  • Objective To explore the changes of cellular immune function in chronic obstructive pulmonary disease patients with infection, and to provide a theoretical basis for COPD patients. Methods Totally 80 patients with COPD complicating infection treated in our hospital from January 2016 to April 2017 were selected as the observation group, contemporaneous 64 patients with simple COPD were selected as the COPD group and 60 healthy people as the control group. The indexes of cellular immunity functions were analyzed in 3 groups. Results (1) In COPD infection group, the average percentage of peripheral blood NK was 19.86 + 10.67, and lower than the COPD group (26.47±10.05) , the difference was statistically significant (P < 0.01) , higher than that of the control group (16.89±5.07) , but the difference was not statistically significant (P > 0.05) . (2) CD3+ cells in peripheral blood of COPD patients with bacterial infection group, COPD group and healthy control group (total T lymphocyte percentage) were (66.64±11.03) , (64.6±11.45) and (67.06±5.55) , there was no significant difference between the three groups (P > 0.05) . (3) In COPD infection group, the peripheral blood CD4 cells and CD4/CD8 ratio were (40.47±10.44) and 1.82 (1.78, 2.57) , higher than the healthy control group[35.01 +7.16 and 1.19 (0.96, 1.66) ], the level of CD8 cells was (23.6±9.82) , lower than the healthy control group (27.50±5.85) , the differences were statistically significant (P < 0.01) ;and COPD group level[ (39.89±9.92) , 2.02 (1.44, 2.83) ] and (21.12±7.64) , there were no statistically significant difference. Conclusions In patients with COPD, the adjuvant immune cell levels are increased but the specific killing immune cells are decreased, on this basis, increased levels of nonspecific killing immune cells help fight infection, immune regulation therapy for COPD patients should focus on improving the level of destruction of immune cells.
  • [1]余志辉, 林涛.慢性阻塞性肺疾病患者T淋巴细胞及细胞因子的表达与分析[J].中国现代药物应用, 2015, 9 (8) :17-18.
    [2]
    [2] VOGELMEIER C F, CRINER G J, MARTINEZ F J, et al.Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report.GOLD executive summary[J].Am J Respir Crit Care Med, 2017, 195 (5) :557-582.
    [3] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组·慢性阻塞性肺疾病诊治指南 (2013年修订版) [J].中华结核和呼吸杂志, 2013, 36 (4) :255-264.
    [4]唐神结.慢性阻塞性肺疾病合并肺结核患者体液核细胞免疫功能的研究[D].苏州:苏州大学临床医学院, 2014.
    [5]马爱平, 赵卉, 李建强.慢性阻塞性肺疾病的免疫治疗进展[J].国际呼吸杂志, 2010, 30 (5) :298-302.
    [6]
    [6]HONG S C, LEE S H.Role of 17 cell and autoimmunity in chronic obstructive pulmonary disease[J].Immune Netw, 2010, 10 (4) :109-114.
    [7]
    [7]ROVINA N, KOUTSOUKOU A, KOULo URIS N G.Inflammation and immune response in COPD:where do we stand[J].Mediators Inflamm, 2013, 2013 (5) :1-9.
    [8]戴百章, 任朝凤, 郑勤玲, 等.慢性阻塞性肺病急性加重患者淋巴细胞组成变化[J].昆明医科大学学报, 2017, 38 (6) :64-67.
    [9]孙巍, 杨永辉, 李登瑞, 等.NKT细胞、NK细胞和T细胞亚群在活动性肺结核患者外周血的表达及意义[J].中国免疫学杂志, 2011, 37 (10) :1141-1144.
    [10]
    [10]XU W H, HU X L, LIU X F, et al. Peripheral Tc17 and Tc17/Interferon-γcells are increased and associated with lung function in patients with chronic obstructive pulmonary disease[J].Chin Med J (Engl) , 2016, 129 (8) :909.
    [11]陈立文, 李崇文.不同病程COPD患者免疫功能的临床分析[J].中国实验诊断学, 2017, 21 (1) :32-34.
    [12]
    [12]SUZUKI M, SZE M A, CAMPBELL J D, et a1.The cellular and molecular determinants of emphysematous destruction in COPD[J].Sci Rep, 2017, 7 (1) :9562.
    [13]曾文, 秦雯, 胡大春, 等.慢性阻塞性肺疾病急性加重期患者T细胞免疫机制变化初探[J].重庆医学, 2018, 47 (6) :2298-2302.
    [14]李文君, 王淑妮, 田佳, 等.调节性T细胞在COPD发病机制中的作用[J].临床肺科杂志, 2014, 19 (1) :128-130.
    [15]韩利红, 张国俊.老年慢性阻塞性肺疾病患者血清细胞因子及细胞免疫的水平及意义[J].中国老年学杂志, 2014, 34 (11) :6065-6066.
  • Relative Articles

    [1] Menghuan LI, Li AI, Yongxia LI. Single-cell RNA Sequencing: A New Perspective in the Study of Chronic Obstructive Pulmonary Disease. Journal of Kunming Medical University, 2025, 46(3): 1-6.  doi: 10.12259/j.issn.2095-610X.S20250301
    [2] Su ZHANG, Zheng HUANG, Na LI, Jing XU, Yiting TAO. A Two Sample Mendelian Randomization Study on Nut Intake and Chronic Obstructive Pulmonary Disease. Journal of Kunming Medical University, 2024, 45(11): 81-86.  doi: 10.12259/j.issn.2095-610X.S20241112
    [3] Qiang WANG, Dexing YANG, Weiyu ZHOU, Jiefu TANG, Kai FU, Zhenfang WANG, Shengzhe LIU, Min LI, Ying LUAN, Rong LIU. Analysis of Prognostic Risk Factors in Patients with Septic Shock Based on Circulatory and Cellular Immune Response Indicators. Journal of Kunming Medical University, 2023, 44(7): 78-87.  doi: 10.12259/j.issn.2095-610X.S20230716
    [4] Jinmei LU, Yuzhu LI, Lin WANG, Xin SU, Jinxiu LIN, Jianhui ZHANG. Study on the Effectiveness of Wearable Device-based Lung Rehabilitation in Patients with COPD. Journal of Kunming Medical University, 2023, 44(11): 175-182.  doi: 10.12259/j.issn.2095-610X.S20231127
    [5] Shulan SHI, Lijuan QIU, Liyue KUI, Min SU, Bailing ZHOU, Rongjie LI, Jianming SUN. Diagnostic Value of Interleukin-6,Interleukin-10,High-sensitivity C-reactive Protein and Procalcitonin in Children with Acute Lymphoblastic Leukemia Complicated by Infection. Journal of Kunming Medical University, 2023, 44(1): 104-108.  doi: 10.12259/j.issn.2095-610X.S20230115
    [6] Jiefu TANG, Dexing YANG, Shengzhe LIU, Qiang WANG, Kai FU, Zhenfang WANG, Ying LUAN, Min LI, Rong LIU. A Study on Prognostic Value of Cellular Immunological Indicators in Omicron Variant Infected Elderly Severe Patients. Journal of Kunming Medical University, 2023, 44(12): 87-94.  doi: 10.12259/j.issn.2095-610X.S20231214
    [7] Tingting YU, Dongling LI, Hongying WANG, Lihua LI, Dong PU, Kunli WU. Investigations on the Infection, Immunity and Drug Resistance of Newly-treated Cases of HIV in Kunming. Journal of Kunming Medical University, 2022, 43(1): 138-143.  doi: 10.12259/j.issn.2095-610X.S20220133
    [8] Li -zhu WANG, Shu-ling LI, Biao RUAN. Clinical Application of Xenogenic Acellular (bovine) Dermal Matrix with Autologous Bone Powder Implantation in Open Mastoidectomy. Journal of Kunming Medical University, 2021, 42(10): 99-105.  doi: 10.12259/j.issn.2095-610X.S20211029
    [9] Ye Xiu Lin , Yang Jiao , Li Min , Fang Yan , Tian Xi , Zhu Wen Zhuo . . Journal of Kunming Medical University, 2020, 41(02): 43-48.
    [10] He-ping LIU, Hong-mei WU, Yang LIU, Chun ZHANG, Wei-zhou WANG, Ding-yun YOU, Hong-xiang WU. Correlation between Anxiety Depression Symptoms of Patients with Chronic Obstructive Pulmonary Disease and CAT Score. Journal of Kunming Medical University, 2020, 41(12): 29-35.  doi: 10.12259/j.issn.2095-610X.S20201212
    [11] Yang Xia , Feng Mei , Wu Ying , Zhu Jing . . Journal of Kunming Medical University, 2019, 40(08): 83-87.
    [12] Huang Li , Huang Xian Xiang . A Study of the Level Expression and Clinical Efficacy of Noninvasive Mechanical Ventilation in the Treatment of Insulin-like Growth Factor Ⅰ, Ⅱ and Cathepsin B in Patients with Chronic Obstructive Pulmonary Disease. Journal of Kunming Medical University, 2018, 39(08): 74-79.
    [13] Bi Hong . The Analysis of Influential Factors of Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease in Kunming. Journal of Kunming Medical University,
    [14] Zeng Hai Ping . . Journal of Kunming Medical University,
    [15] Yang Huan Zhi . . Journal of Kunming Medical University,
    [16] Dong Yu . . Journal of Kunming Medical University,
    [17] Liu Yi . . Journal of Kunming Medical University,
    [18] Liu Shi Chang . . Journal of Kunming Medical University,
    [19] Cun Xin Hua . . Journal of Kunming Medical University,
    [20] . . Journal of Kunming Medical University,
  • Cited by

    Periodical cited type(13)

    1. 黎清梅,江建宁,苏明华,苏土梅,殷倩冰,胡伯斌,王荣明,梁蘅恺,韦璐,冯彦菲. 富马酸丙酚替诺福韦和替诺福韦酯治疗慢性乙型肝炎初治患者的临床效果及应答不佳的处理方案探讨. 中国医药. 2024(01): 65-69 .
    2. 程家喜,王万党,石梅彬,黄祥亚,杨洁,李巧珊,邹绮明,李娟. 恩替卡韦、富马酸替诺福韦二吡呋酯及富马酸丙酚替诺福韦治疗慢性乙型肝炎的疗效及安全性分析. 传染病信息. 2024(01): 11-15 .
    3. 董艳飞,钟兵,刘冰. 富马酸丙酚替诺福韦片治疗慢性乙型肝炎合并脂肪肝的临床疗效及安全性. 临床合理用药. 2024(23): 69-73 .
    4. 曹思远,赵甫文,杨佳丽,李孟菲,毛艳琦,杨周雨,张蕾. 一线核苷类药物治疗慢性乙型肝炎的文献计量学分析. 滨州医学院学报. 2024(05): 409-413 .
    5. 杨梅,刘兴超,郑波. 乙肝扶正胶囊联合丙酚替诺福韦治疗慢性乙型肝炎的临床研究. 现代药物与临床. 2023(07): 1707-1711 .
    6. 陈燕霞,黎坚健,邝德志. 富马酸丙酚替诺福韦治疗慢性乙肝临床抗病毒的疗效分析. 系统医学. 2023(14): 89-92 .
    7. 张文海. 温补脾肾方联合替诺福韦治疗脾肾两虚型慢性乙型肝炎的临床研究. 中国实用医药. 2022(02): 182-184 .
    8. 李薇,邱利,董丹丹. 富马酸替诺福韦二吡呋酯治疗慢性乙型肝炎60例. 中西医结合肝病杂志. 2022(02): 128-130 .
    9. 王明杰. 富马酸丙酚替诺福韦治疗慢性乙型肝炎的研究进展. 现代诊断与治疗. 2022(05): 668-670 .
    10. 曹珍. 2016~2020年南通市第三人民医院核苷类抗病毒药使用分析. 中国处方药. 2022(09): 56-58 .
    11. 王超,郭立杰,修宪,张海丛,冯彩霞. 丙酚替诺福韦对比替诺福韦酯治疗HBeAg阳性乙肝患者的成本-效果分析. 中国医院药学杂志. 2022(18): 1934-1938 .
    12. 武华周,舒伟,王喆,潘学春,柴雨柱,徐丹,朱春霞. 富马酸丙酚替诺福韦杂质的合成. 精细与专用化学品. 2022(10): 33-37 .
    13. 张涛,李赛帅,刁勤峰. 替诺福韦治疗乙型肝炎病毒感染孕妇的疗效及安全性分析. 中国实用医药. 2021(27): 147-149 .

    Other cited types(6)

  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2386) PDF downloads(42) Cited by(19)
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return