Expression and Clinical Significance of LAPTM4B in Endometrial Carcinoma

Ding Li Jun; Tian Jie; Li Xiao Lan

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Ding Li Jun , Tian Jie , Li Xiao Lan . Expression and Clinical Significance of LAPTM4B in Endometrial Carcinoma[J]. Journal of Kunming Medical University, 2019, 40(03): 87-91.

Citation:

Ding Li Jun , Tian Jie , Li Xiao Lan . Expression and Clinical Significance of LAPTM4B in Endometrial Carcinoma[J]. Journal of Kunming Medical University, 2019, 40(03): 87-91.

Ding Li Jun , Tian Jie , Li Xiao Lan . Expression and Clinical Significance of LAPTM4B in Endometrial Carcinoma[J]. Journal of Kunming Medical University, 2019, 40(03): 87-91.

Citation:

Ding Li Jun , Tian Jie , Li Xiao Lan . Expression and Clinical Significance of LAPTM4B in Endometrial Carcinoma[J]. Journal of Kunming Medical University, 2019, 40(03): 87-91.

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Expression and Clinical Significance of LAPTM4B in Endometrial Carcinoma

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基金：湖北省自然科学基金资助项目 (2015CFB574);

Received Date: 2018-10-20

Abstract

Abstract

Objective To investigate the expression and clinical significance of LAPTM4 B in endometrial carcinoma. Methods A total of 76 cases of patients with endometrial carcinoma who underwent surgery were selected in our hospital from March 2011 to March 2013. In the same period, 40 cases of normal endometrial tissues were selected as the control group. The expressions of LAPTM4 B proteins in endometrial carcinoma and control group tissues were detected by immunohistochemistry. All patients were followed up, and the follow-up deadline was March 31, 2018. Four patients were lost during the follow-up period, and the follow-up rate was 93.42%. Survival analysis was using Kaplan-Meier method and Log-Rank test. Multivariate analysis of factors affecting patient prognosis was using Cox proportional hazard regression model. Results The positive expression rate of LAPTM4 B protein in endometrial carcinoma tissues was 73.68%, which was higher than that in control group (27.50%) , the difference was statistically significant (χ2= 22.911, P < 0.001) . The differences of the expression of LAPTM4 B proteins in different FIGO stages, different degrees of differentiation and lymph node metastasis were statistically significant (P < 0.05) . Kaplan-Meier survival analysis showed that the average survival time in the positive expression group was (42.76±4.16) months, the survival rate was 33.96%, while in the negative expression group were (71.53 ±4.78) months and 78.95%, respectively, Log-Rank test showed the difference was statistically significant (χ2= 10.458, P = 0.001) . Cox proportional hazards regression showed that the degree of differentiation, lymph node metastasis and LAPTM4 B protein expression were factors influencing the prognosis of patients (HR=0.436, 5.993 and 3.052, P < 0.05) . Conclusions The expression of LAPTM4 B protein in endometrial carcinoma tissues is upregulated, and is related to the malignant progression of the tumor and the prognosis. It is a risk factor affecting the prognosis of patients.
- Endometrial cancer,
- LAPTM4B,
- Prognosis,
- Cox proportional hazards regression model

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References(14)

References

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