Effect of Amphotericin B Irrigation on Eosinophils and Epithelization Time in Patients with Refractory Rhinosinusitis after Nasal Endoscopic Surgery

Cai Run Zhuo; Zeng Ling Da; Li Deng Hui; Zhu Li Ming

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Article Navigation > Journal of Kunming Medical University > 2019 > 40(03): 92-96

Cai Run Zhuo , Zeng Ling Da , Li Deng Hui , Zhu Li Ming . Effect of Amphotericin B Irrigation on Eosinophils and Epithelization Time in Patients with Refractory Rhinosinusitis after Nasal Endoscopic Surgery[J]. Journal of Kunming Medical University, 2019, 40(03): 92-96.

Citation:

Cai Run Zhuo , Zeng Ling Da , Li Deng Hui , Zhu Li Ming . Effect of Amphotericin B Irrigation on Eosinophils and Epithelization Time in Patients with Refractory Rhinosinusitis after Nasal Endoscopic Surgery[J]. Journal of Kunming Medical University, 2019, 40(03): 92-96.

Citation:

Cai Run Zhuo , Zeng Ling Da , Li Deng Hui , Zhu Li Ming . Effect of Amphotericin B Irrigation on Eosinophils and Epithelization Time in Patients with Refractory Rhinosinusitis after Nasal Endoscopic Surgery[J]. Journal of Kunming Medical University, 2019, 40(03): 92-96.

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Effect of Amphotericin B Irrigation on Eosinophils and Epithelization Time in Patients with Refractory Rhinosinusitis after Nasal Endoscopic Surgery

Funds:

基金：辽宁省科技攻关计划项目 (2015S2650142);

Received Date: 2018-10-19

Abstract

Abstract

Objective To study the effects of amphotericin B irrigation on eosinophils (Eos) and epithelization time in patients with refractory rhinosinusitis after nasal endoscopic surgery. Methods The random number table method was performed to divided the 86 patients with refractory rhinosinusitis undergoing nasal endoscopic surgery in Otolaryngology&Head and Neck Surgery, Jinzhou Central Hospital, into two groups, 43 cases in each group. The control group was given routine treatment after surgery, while the study group was treated with amphotericin B irrigation on the basis of routine treatment. The T lymphocyte subsets (CD3+, CD4+, CD8+and CD4+/CD8+) , Eos count, inflammatory factors [interleukin 2 (IL-2) , interleukin 4 (IL-4) , interleukin5 (IL-5) , serum interferon γ (IFN-γ) ], epithelization time, postoperative recurrence rate, swelling degree and curative effect were compared between the two groups. Results The total response rate of postoperative curative effect in the study group was significantly higher than that in the control group (95.35% vs 81.40%) (P <0.05) . At 1 month after surgery, CD3+, CD4+, CD8+and CD4+/CD8+in the study group were significantly higher than those in the control group (P < 0.05) , while Eos count, levels of IL-2, IL-4, IL-5 and IFN-γ were significant lower than those in the control group (P < 0.05) . At 7 days after surgery, the VAS score and severe swelling rate in the study group were significantly lower than those in the control group (P < 0.05) . The epithelization time was shorter than that in the control group (P < 0.05) . The recurrence rate in the study group was significantly lower than that in the control group (P < 0.05) . Conclusion The application of amphotericin B irrigation in patients with refractory rhinosinusitis after nasal endoscopic surgery can effectively enhance the immune function, improve inflammation, relieve degree of swelling and pain, reduce Eos, shorten the epithelization time, and reduce the postoperative recurrence rate.
- Amphotericin B,
- Refractory rhinosinusitis,
- Nasal endoscopic surgery,
- Eosinophils,
- Epithelialization

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References(24)

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