Analysis of Clinicopathological Features of 274 Cases of Pancreatic Cancer and Risk Factors Affecting Prognosis

Shen Hong; Wang Xiu Yun; Xu Hui Qiong; Liu Xia

Volume 40 Issue 03

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Shen Hong , Wang Xiu Yun , Xu Hui Qiong , Liu Xia . Analysis of Clinicopathological Features of 274 Cases of Pancreatic Cancer and Risk Factors Affecting Prognosis[J]. Journal of Kunming Medical University, 2019, 40(03): 97-101.

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Shen Hong , Wang Xiu Yun , Xu Hui Qiong , Liu Xia . Analysis of Clinicopathological Features of 274 Cases of Pancreatic Cancer and Risk Factors Affecting Prognosis[J]. Journal of Kunming Medical University, 2019, 40(03): 97-101.

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Analysis of Clinicopathological Features of 274 Cases of Pancreatic Cancer and Risk Factors Affecting Prognosis

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基金：四川省科技厅科技支撑计划基金资助项目 (16PJ30170);

Received Date: 2018-10-20

Abstract

Abstract

Objective To analyze the clinicopathological features of pancreatic cancer and the risk factors affecting the prognosis. Methods The clinical data and follow-up condition of 274 patients with pancreatic cancer in our hospital from March 2012 to March 2017 were retrospectively analyzed (the follow-up was until June 2018 or the patient died) . Kaplan-Meier method was used to evaluate the survival of patients. Log-rank test was used for univariate analysis. Cox proportional hazard regression model was used for multivariate analysis to screen out the risk factors affecting the prognosis of patients with pancreatic cancer. Results By the end of follow-up, 242 cases died and 32 cases survived among 274 cases of patients, and the median survival time was 5.7 months, and the1-year, 2-year and 3-year survival rates were 24.6%, 10.7% and 4.6% respectively. Univariate analysis showed that tumor location, tumor size, c TNM stage, presence or absence of liver metastasis or lymph node metastasis, treatment methods, serum CEA level, serum CA199 level, serum CA242 level and NLR were associated with prognosis in patients with pancreatic cancer (P < 0.05) , but gender, age, BMI, presence or absence of diabetes history or smoking history, serum ALB level were not associated with prognosis in patients with pancreatic cancer (P > 0.05) . Cox multivariate analysis showed that tumor size > 2 cm, c TNM stage III-IV, lymph node metastasis, serum CA199 > 37 U/m L, serum CA242 > 20 U/m Ll and NLR > 4 were independent risk factors for prognosis of patients with pancreatic cancer (P<0.05) , and surgical treatment was a beneficial factor for prognosis of patients with pancreatic cancer (P < 0.05) . Conclusions Tumor size, c TNM stage, lymph node metastasis, serum CA199 and CA242 levels, NLR and treatment methods are closely related to the prognosis of patients with pancreatic cancer.
- Pancreatic cancer,
- Clinicopathological features,
- Prognosis,
- Risk factors

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