Research Progress of DRD1 in Neurological Disorders and Functions

Jinyu LI; Liangsheng FENG; Yang GAO; Yu LI; Bangxu WU; Yingying ZOU

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Jinyu LI, Liangsheng FENG, Yang GAO, Yu LI, Bangxu WU, Yingying ZOU. Research Progress of DRD1 in Neurological Disorders and Functions[J]. Journal of Kunming Medical University.

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Jinyu LI, Liangsheng FENG, Yang GAO, Yu LI, Bangxu WU, Yingying ZOU. Research Progress of DRD1 in Neurological Disorders and Functions[J]. Journal of Kunming Medical University.

Jinyu LI, Liangsheng FENG, Yang GAO, Yu LI, Bangxu WU, Yingying ZOU. Research Progress of DRD1 in Neurological Disorders and Functions[J]. Journal of Kunming Medical University.

Citation:

Jinyu LI, Liangsheng FENG, Yang GAO, Yu LI, Bangxu WU, Yingying ZOU. Research Progress of DRD1 in Neurological Disorders and Functions[J]. Journal of Kunming Medical University.

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Research Progress of DRD1 in Neurological Disorders and Functions

1.
The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
The School of Basic Medicine of Kunming Medical University，Kunming Yunnan 650500，China

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Corresponding author: 邹英鹰，教授，博士生/硕士生导师, 云南省“兴滇英才支持计划” 教学名师、享受云南省特殊津贴专家、云南省中青年学术和技术带头人、云南省卓越青年教师，从事病理学教学科研工作24年。职务：副院长。长期致力于糖尿病性中枢神经损伤及保护的研究，取得一定的相关成果。包括发现糖尿病长期病变可导致视网膜、海马、嗅球、小脑等多部位损伤及其功能障碍，提出这些部位损伤的部分分子机制，并积极开展云南特色药物天麻素修复糖尿病性中枢神经系统损伤的机制研究。先后主持各级科研项目8项，其中国家自然科学基金项目4项、省级重点项目1项等。目前以通讯、第一作者发表较高水平外文论文15篇。此外，主持各级病理学课程及教学改革项目10项，其中包括国家级一流本科课程2门、省部级教学项目3项、校级质量工程项目5项等。担任第二届中国研究型医院学会超微与分子病理学专业委员会委员、中华医学会病理学分会第十二届委员会病理学教学工作委员会委员、云南省医师协会病理医师分会第三届委员会常委等。
Received Date: 2024-01-11
Available Online: 2024-04-29

Abstract

Abstract

Dopamine D1 receptor （DRD1） is currently known as the dopamine receptor subtype with the most widespread expression in the nervous system. DRD1 plays a role in various signaling pathways to perform many functions such as movement, emotion, cognition, learning and memory, as well as neuroendocrine activities. These functions may be associated with conditions like Parkinson's syndrome, schizophrenia, depression, and immune responses. Changes in the expression of DRD1 often indicate alterations in neurological functions. Therefore, DRD1 has the potential to serve as an indicator of neurological disorders and functional changes, as well as a potential target for the treatment of neurological diseases. This article reviews the distribution and functions of DRD1 in the nervous system, with a particular emphasis on DRD1's involvement in signaling pathways related to the nervous system.
- Dopamine receptor,
- Nervous system,
- DRD1,
- DA

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References(61)

References

[1]	Sioka C,Fotopoulos A,Kyritsis A P. Recent advances in PET imaging forevaluation of Parkinson's disease[J]. Eur J Nucl Med Mol Imaging,2010,37(8):1594-1603. doi: 10.1007/s00259-009-1357-9
[2]	Wei X,Ma T,Cheng Y,et al. Dopamine D1 or D2 receptor-expressing neurons in the central nervous system[J]. Addict Biol,2018,23(2):569-584. doi: 10.1111/adb.12512
[3]	Zang X,Cheng Z Y,Sun Y,et al. The ameliorative effects and underlying mechanisms of dopamine D1-like receptor agonist SKF38393 on Aβ1-42-induced cognitive impairment[J]. Prog Neuropsychopharmacol Biol Psychiatry,2018,2(81):250-261.
[4]	Kim M,Custodio R J,Lee H J,et al. Per2 Expression regulates the spatial working memory of mice through DRD1-PKA-CREB signaling[J]. Mol Neurobiol,2022,59(7):4292-4303. doi: 10.1007/s12035-022-02845-z
[5]	C Missale 1, SR Nash, SW Robinson, et al. Dopamine receptors: From structure to function[J]. Physiol Rev,1998,78(1):189-225.
[6]	Trzaskowski B,Latek D,Yuan S,et al. Action of molecular switches in GPCRs-theoretical and experimental studies[J]. Curr Med Chem,2012,19(8):1090-1109.
[7]	曹国祥. 多巴胺受体显像剂的研究概况[J]. 国外医学(放射医学核医学分册),1999,23(2):65-67
[8]	Wen X S,Chen X M,Rong F,et al. The regulation of SKF38393 on the dopamine and D1 receptor expression in hippocampus during chronic REM sleep restriction[J]. CNS Neurosci Ther,2013,19(9):730-733. doi: 10.1111/cns.12140
[9]	乔晋萍,乔洪文,武仙英,等. 多巴胺神经系统显像分子探针研究[J]. 生命的化学,2014,34(2):154-165.
[10]	Gouveri E,Katotomichelakis M,Gouveris H,et al. Olfactory dysfunction in type 2 diabetes mellitus: an additional manifestation of microvascular disease?[J]Angiology,2014,65(10): 869-876.
[11]	李瑞,范运龙,刘海鹰,等. 多巴胺D1受体在小鼠大脑皮层的空间分布研究[J]. 神经解剖学杂志,2019,35(3):229-235.
[12]	De Bundel D,Femen í a T,DuPont C M,et al. Hippocampal and prefrontal dopamine D1/5 receptor involvement in the memory-enhancing effect of reboxetine[J]. Int J Neuropsychopharmacol,2013,16(9):2041-51. doi: 10.1017/S1461145713000370
[13]	Liu A,Ding S. Anti-inflammatory Effects of Dopamine in lipopolysaccharide (LPS)-stimulated RAW264.7 cells via inhibiting NLRP3 inflammasome activation[J]. Ann Clin Lab Sci,2019,49(3):353-360.
[14]	Seamans J K,Yang C R. The principal features and mechanisms of dopamine modulation in the prefrontal cortex[J]. Prog Neurobiol,2004,74(1):1-57. doi: 10.1016/j.pneurobio.2004.05.006
[15]	张国炳, 陈峻严, 孙文栋,等. 多巴胺D1受体基因(-48A/G)多态性与额叶挫裂伤后认知障碍相关性[J]. 中华实验外科杂志,2016,33(4):993-996.
[16]	J M Beaulieu,S Espinoza,R R Gainetdinov. Dopamine receptors - IUPHAR Review 13[J]. Britisch Journal of Pharmacology,2015,172(1): 1-23.
[17]	王功伍,蔡景霞. 海马-前额叶神经回路与工作记忆[J]. 动物学研究,2010,31(1):50-56.
[18]	Tsang J,Fullard J F,Giakoumaki S G,et al. The relationship between dopamine receptor D1 and cognitive performance. NPJ Schizophr,2015,4(1): 14002.
[19]	El-Ghundi M,Fletcher P J,Drago J,et al. Spatiallearning deficit in dopamine D(1) receptor knockout mice[J]. Eur J Pharmacol,1999,383(2):95-106. doi: 10.1016/S0014-2999(99)00573-7
[20]	Tractenberg S G,Orso R,Creutzberg K C,et al. Vulnerable and resilient cognitive performance related to early life stress: The potential mediating role of dopaminergic receptors in the medial prefrontal cortex of adult mice[J]. Int J Dev Neurosci,2020,80(1):13-27. doi: 10.1002/jdn.10004
[21]	胡一文,王高华,顾剑. 精神分裂症患者多巴胺D1受体基因-48A/G多态性与认知功能的关系[J]. 中国神经精神疾病杂志,2006,32(6):523-526. doi: 10.3969/j.issn.1002-0152.2006.06.009
[22]	李凡,舒斯云,包新民. 多巴胺受体的结构和功能[J]. 中国神经科学杂志,2003,19(6):405-410.
[23]	Smith, Y Raju, DV Pare, et al. The thalamostriatal system: A highly specific network of the basal ganglia circuitry[J]. Trends Neurosci,2004,27(9):520-527.
[24]	Darmopil S, Martín A B, De Diego I R, et al. Genetic inactivation of dopamine D1 but not D2 receptors inhibits L-DOPA-induced dyskinesia and histone activation[J]. Biol Psychiatry,2009,66(6):603-613.
[25]	Reid K M,Steel D,Nair S,et al. Loss-of-function variants in DRD1 in infantile Parkinsonism-dystonia[J]. Cells,2023,12(7):1046.
[26]	Toma C,Herv á s A,Balmaña N,et al. Neurotransmitter systems and neurotrophic factors in autism: Association study of 37 genes suggests involvement of DDC[J]. World J Biol Psychiatry,2013,14(7):516-527. doi: 10.3109/15622975.2011.602719
[27]	Cartier E,Hamilton P J,Belovich A N,et al. Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors[J]. EBio Medicine,2015,2(2):135-146. doi: 10.1016/j.ebiom.2015.01.007
[28]	Corrales E,Navarro A,Cuenca P,et al. Candidate gene study reveals DRD1 and DRD2 as putative interacting risk factors for youth depression[J]. Psychiatry Res,2016,244(11):71-77.
[29]	Altier N, Stewart J. The role of dopamine in the nucleus accumbens in analgesia[J]. Life Science,1999,65(22):2269-2287.
[30]	Odum A L. Delay discounting: I'm a k,you're a k[J]. J Exp Anal Behav,2011,96(3):427-439. doi: 10.1901/jeab.2011.96-423
[31]	Bickel W K,Jarmolowicz D P,Mueller E T,et al. Excessive discounting of delayed reinforcers as a trans-disease process contributing to addiction and other disease-related vulnerabilities: Emerging evidence[J]. Pharmacol Ther,2012,134(3):287-297. doi: 10.1016/j.pharmthera.2012.02.004
[32]	Moses T E H,Burmeister M,Greenwald M K. Heroin delay discounting and impulsivity: Modulation by DRD1 genetic variation[J]. Addict Biol,2020,25(3):e12777. doi: 10.1111/adb.12777
[33]	Ashe M L,Newman M G,Wilson S J. Delay discounting and the use of mindful attention versus distraction in the treatment of drug addiction: A conceptual review[J]. J Exp Anal Behav,2015,103(1):234-248. doi: 10.1002/jeab.122
[34]	Lee W,Ray R,Bergen A W,et al,Thomas P. DRD1 associations with smoking abstinence across slow and normal nicotine metabolizers[J]. Pharmacogenet Genomics,2012,22(7):551-4. doi: 10.1097/FPC.0b013e3283539062
[35]	Yan Y,Jiang W,Liu L,et al. Dopamine controlssystemic inflammation through inhibition of NLRP3 inflammasome[J]. Cell,2015,160(1-2):62-73. doi: 10.1016/j.cell.2014.11.047
[36]	Cosentino M,Fietta A M,Ferrari M,et al. Human CD4⁺CD25⁺ regulatory T cells selectively express tyrosine hydroxylase and contain endogenous catecholaminessubserving an autocrine/paracrine inhibitory functional loop[J]. Blood,2007,109(2):632-642. doi: 10.1182/blood-2006-01-028423
[37]	Ferrari M,Cosentino M,Marino F,et al. Dopaminergic D1-like receptor-dependent inhibition of tyrosine hydroxylase mRNAexpression and catecholamine production in human lymphocytes[J]. Biochem Pharmacol,2004,67(5):865-873. doi: 10.1016/j.bcp.2003.10.004
[38]	Tsunoda M. Role of catecholamine metabolism in blood pressure regulation using chemiluminescence reactiondetection[J]. Yakugaku Zasshi,2008,128(11):1589-1594 . doi: 10.1248/yakushi.128.1589
[39]	M ravec B. Role of catecholamine-induced activation of vagal afferent pathways in regulation of sympathoadrenal system activity: Negative feedback loop of stress response[J]. Endocr Regul,2011,45(1):37-41 .
[40]	Nakano K,Higashi T,Takagi R,et al,Matsushita S. Dopaminereleased by dendritic cells polarizes Th2 differentiation[J]. Int Immunol,2009,21(6):645-654. doi: 10.1093/intimm/dxp033
[41]	Zanassi P,Paolillo M,Montecucco A,et al. Pharmacological and molecular evidence for dopamine D(1) receptor expression bystriatal astrocytes in culture[J]. J Neurosci Res,1999,58(4):544-552. doi: 10.1002/(SICI)1097-4547(19991115)58:4<544::AID-JNR7>3.0.CO;2-9
[42]	Zhang X,Zhou Z,Wang D,et al. Activation of phosphatidylinositol-linked D1-like receptor modulates FGF-2expression in astrocytes via IP3-dependent Ca2+ signaling[J]. J Neurosci,2009,29(24):7766-7775 . doi: 10.1523/JNEUROSCI.0389-09.2009
[43]	Beaulieu J M,Gainetdinov R R. The physiology,signaling,and pharmacology of dopamine receptors[J]. Pharmacological Reviews,2011,63(1):182-217. doi: 10.1124/pr.110.002642
[44]	Reid K M,Steel D,Nair S,et al. Loss-of-function variants in DRD1 in infantile Parkinsonism-dystonia[J]. Cells,2023,12(7):1046 doi: 10.3390/cells12071046
[45]	张超洁,商亚珍. CREB与阿尔茨海默病[J]. 承德医学院学报,2023,40(3):237-241.
[46]	Brami-Cherrier K,Valjent E,Garcia M,et al. Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: A new route to cAMP response element-binding protein phosphorylation[J]. J Neurosci,2002,22(20):8911-8921. doi: 10.1523/JNEUROSCI.22-20-08911.2002
[47]	Monsma F J,Jr.,Mahan L C,et al. Molecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation[J]. Proc Natl Acad Sci USA,1990,87(17):6723-6727. doi: 10.1073/pnas.87.17.6723
[48]	Cosentino M,Kustrimovic N,Ferrari M,et al. cAMP levels in lymphocytes and CD4+ regulatory T-cell functions are affected by dopamine receptor gene polymorphisms[J]. Immunology,2018,153(3):337-341. doi: 10.1111/imm.12843
[49]	D’ SaC ,DumanRS . Antidepressants and neuroplasticity[J]. Bipolar Disord,2002,4(3): 183-194.
[50]	李云峰,杨明,赵毅民,等. 巴戟天寡糖对皮质酮损伤的PC12细胞的保护作用[J]. 中国中药杂志,2000,25(9):39-42.
[51]	李云峰,罗质璞. 丁螺环酮对皮质酮所致PC12细胞损伤的保护作用[J]. 中国药理学与毒理学杂志,2001,15(5):333-336.
[52]	Yan Y,Jiang W,Liu L,et al. Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome[J]. Cell,2015,160(1-2):62-73. doi: 10.1016/j.cell.2014.11.047
[53]	Yang C,Kazanietz M G. Divergence and complexities in DAG signaling: Looking beyond PKC[J]. Trends Pharmacol Sci,2003,24(11):602-608. doi: 10.1016/j.tips.2003.09.003
[54]	Felder C C,Jose P A,Axelrod J. The dopamine-1 agonist,SKF 82526,stimulates phospholipase-C activity independent of adenylate cyclase[J]. J Pharmacol Exp Ther,1989,248(1):171-175.
[55]	Berridge M J. Inositol trisphosphate and calcium signalling mechanisms[J]. Biochim Biophys Acta,2009,1793(6):933-940. doi: 10.1016/j.bbamcr.2008.10.005
[56]	Qin D,Liu P,Chen H,et al. Salicylate-induced ototoxicity of spiral ganglion neurons: Ca2⁺/CaMKII-mediated interaction between NMDA receptor and GABAA receptor[J]. Neurotox Res,2019,35(4):838-847. doi: 10.1007/s12640-019-0006-8
[57]	Zeng C,Villar V A,Yu P,et al. Reactive oxygen species and dopamine receptor function in essential hypertension[J]. Clin Exp Hypertens,2009,31(2):156-178. doi: 10.1080/10641960802621283
[58]	Kansra V,Chen C J,Lokhandwala M F. Dopamine fails to stimulate protein kinase C activity in renal proximal tubules of spontaneously hypertensive rats[J]. Clin Exp Hypertens,1995,17(5):837-845. doi: 10.3109/10641969509033638
[59]	Kim B,Yun J,Park B. Methamphetamine-induced neuronal damage: Neurotoxicity and neuroinflammation[J]. Biomol Ther,2020,28(5):381-388.
[60]	Premoli M. , Aria F., Bonini S. A., et al. Cannabidiol: Recent advances and new insights for neuropsychiatric disorders treatment[J]. Life Sci,2019,224(1):120-127.
[61]	Vitale R. M., Iannotti F. A., Amodeo P. The (poly)pharmacology of cannabidiol in neurological and neuropsychiatric disorders: Molecular mechanisms and targets[J]. International Journal of Molecular Sciences,2021,22(9):4876.

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